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Intensive Care Medicine Experimental

Table 3 Course of haemodynamic parameters during intra-abdominal hypertension with estimated differences between groups

From: Individualised flow-controlled ventilation reduces applied mechanical power and improves ventilation efficiency in a porcine intra-abdominal hypertension model

IAH

FCVa (n = 9)

PCVa (n = 9)

Estimate with 95% CIb

p-valuec

HR [/min]

    

 Grade 0

65

69

− 4 (− 10 to 2)

0.1771

 Grade 1

64

65

− 1 (− 8 to 6)

0.7495

 Grade 2

64

62

2 (− 6 to 9)

0.6609

 Grade 3

65

60

5 (− 6 to 16)

0.4307

MAP [mmHg]

    

 Grade 0

76

74

1 (− 5 to 7)

0.6916

 Grade 1

82

83

− 1 (− 7 to 5)

0.7650

 Grade 2

87

87

0 (− 9 to 9)

1

 Grade 3

93

90

3 (− 6 to 12)

0.5040

MPAP [mmHg]

    

 Grade 0

25

26

− 1 (− 4 to 3)

0.7586

 Grade 1

32

34

− 2 (− 7 to 3)

0.5173

 Grade 2

35

35

1 (− 4 to 5)

0.7806

 Grade 3

40

36

3 (− 1 to 7)

0.1224

CVP [mmHg]

    

 Grade 0

13

14

− 1 (− 4 to 3)

0.7658

 Grade 1

20

21

0 (− 4 to 3)

0.8168

 Grade 2

25

23

2 (− 1 to 5)

0.2497

 Grade 3

27

24

3 (0 to 7)

0.0809

PCWP [mmHg]

    

 Grade 0

14

15

− 1 (− 4 to 2)

0.4726

 Grade 1

20

21

− 1 (− 5 to 3)

0.6657

 Grade 2

21

21

0 (− 3 to 4)

0.8261

 Grade 3

23

22

1 (− 3 to 4)

0.7519

CI [l/min/m2]

    

 Grade 0

5.3

5.7

− 0.4 (− 1.3 to 0.5)

0.3783

 Grade 1

4.8

5.6

− 0.7 (− 1.4 to − 0.1)

0.0407*

 Grade 2

4.6

4.9

− 0.3 (− 1.0 to 0.3)

0.3469

 Grade 3

3.8

4.2

− 0.5 (− 1.0 to 0.0)

0.0661

SVRI [dyn·s/cm5/m2]

    

 Grade 0

990

788

202 (3 to 401)

0.0641

 Grade 1

1024

798

226 (31 to 421)

0.0373*

 Grade 2

1106

965

141 (− 143 to 426)

0.3455

 Grade 3

1427

1098

329 (26 to 632)

0.0502

PVRI [dyn·s/cm5/m2]

    

 Grade 0

170

148

23 (− 24 to 69)

0.3529

 Grade 1

205

155

50 (0 to 100)

0.0656

 Grade 2

250

206

45 (− 44 to 133)

0.3383

 Grade 3

346

237

110 (16 to 204)

0.0362*

  1. CI cardiac index, CVP central venous pressure, FCV flow-controlled ventilation, HR heart rate, MAP mean arterial pressure, MPAP mean pulmonary arterial pressure, PCV pressure-controlled ventilation, PCWP pulmonary capillary wedge pressure, PVRI pulmonary vascular resistance index, SVRI systemic vascular resistance index
  2. aContinuous data are presented as medians
  3. bEstimated median difference for continuous variables
  4. cAssessed by Wilcoxon rank sum test for continuous variables, significant differences (p < 0.05) are marked with an asterisk
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