Fig. 5

Effects of age on plasma levels of IL-6, IL-10, TAT, CFDNA, CCL2, ADAMTS13 activity, and lung MPO in a 72 h FIP model of sepsis. IL-6 (A), IL-10 (B), MPO (C), TAT (D), CFDNA (E), CCL2 (F), and ADAMTS13 activity (G) over time in aged and young FIP survivors and non-survivors and in sham and naive mice. Mice that survived till experimental endpoint are designated as survivors. Mice that were humanely euthanized according to their MSS are designated as non-survivors. Aged FIP (n = 8), young FIP (n = 10-12), aged sham (n = 3), aged naïve (n = 4-6), young sham (n = 3), and young naïve (n = 4-6). Data are presented as mean ± SD from aged FIP and the data was analyzed using a mixed-effects analysis. P-values < 0.05 were considered significant.