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Table 2 Results of linear mixed-effects models: association between coronary artery calcification tertiles and vectorcardiography variables

From: The association between coronary artery calcification and vectorcardiography in mechanically ventilated COVID-19 patients: the Maastricht Intensive Care COVID cohort

 

QRS-Area (µVs)

QRS Duration (ms)

QRS Amplitude (mV)

β (95%CI); p-value

β (95%CI); p-value

β (95%CI); p-value

Model 1: Crude

   

 Tertile 1 (reference)

–

–

–

 Average difference tertile 2

 − 0.84 (− 6.13; 4.44); 0.753

4.45 (− 3.02; 11.93); 0.242

 − 0.05 (− 0.18; 0.08); 0.447

 Interaction tertile 2 and time (days)

 − 0.05 (− 0.20; 0.10); 0.527

0.00 (− 0.24; 0.24); 0.982

0.00 (− 0.00; 0.01); 0.601

 Average difference tertile 3

6.65 (1.50; 11.81); 0.012*

12.02 (4.74; 19.30); 0.001*

0.07 (− 0.05; 0.19); 0.271

 Interaction tertile 3 and time (days)

 − 0.27 (− 0.43; − 0.11); 0.001*

0.04 (− 0.21; 0.29); 0.738

 − 0.01 (− 0.01; − 0.00); 0.029*

Model 2: Model 1 adjusted for age, sex, and APACHE − II score

 Tertile 1 (reference)

–

–

–

 Average difference tertile 2

0.56 (− 5.03; 6.15); 0.844

 − 0.45 (− 7.87; 6.96); 0.904

0.02 (− 0.11; 0.15); 0.777

 Interaction tertile 2 and time (days)

 − 0.05 (− 0.20; 0.10); 0.533

0.00 (− 0.23; 0.24); 0.985

0.00 (− 0.00; 0.01); 0.563

 Average difference tertile 3

8.50 (2.69; 14.30); 0.004*

6.07 (− 1.53; 13.67); 0.118

0.16 (0.02; 0.30); 0.023*

 Interaction tertile 3 and time (days)

 − 0.27 (− 0.43; − 0.11); 0.001*

0.04 (− 0.21; 0.29); 0.772

 − 0.01 (− 0.01; − 0.00); 0.038*

Model 3: Model 2 adjusted for chronic lung disease and liver conditions

 Tertile 1 (reference)

–

–

–

 Average difference tertile 2

0.55 (− 5.10; 6.19); 0.849

 − 0.30 (− 7.78; 7.18); 0.937

0.02 (− 0.11; 0.16); 0.717

 Interaction tertile 2 and time (days)

 − 0.05 (− 0.20; 0.10); 0.533

0.00 (− 0.24; 0.24); 1.000

0.00 (− 0.00; 0.01); 0.542

 Average difference tertile 3

8.26 (2.46; 14.05); 0.006*

6.31 (− 1.31; 13.93); 0.105

0.16 (− 0.02; 0.29); 0.025*

 Interaction tertile 3 and time (days)

 − 0.27 (− 0.43; − 0.11); 0.001*

0.03 (− 0.22; 0.28); 0.804

 − 0.01 (− 0.01; 0.00); 0.040*

  1. Regression coefficients (β) indicate the average difference of the variable under study between CAC tertiles, with tertile 1, the lowest CAC, as reference. The interaction between a tertile with time indicates the average increase or decrease over time. APACHE-II Acute Physiology And Chronic Health Evaluation score.*p-value < 0.05 and a p-value for interaction < 0.10