Table 2 Physiologic and pathologic data of all patients at the four study time points

Isoflurane insp (%)

0 [0. 0]^{*T1. T2}

0.33 [0.19, 0.39] ^{*T0. T3}

0.35 [0.21, 0.55]^{*T0. T3}

0 [0. 0]^{*T1. T2}

Isoflurane exp (%)

0 [0. 0]^{*T1. T2}

0.65 [0.46, 0.81]^{*T0, T3}

0.78 [0.55, 1.00]^{*T0. T3}

0 [0. 0]^{*T1. T2}

LiMAx

(µg kg⁻¹ h⁻¹)

177 [129, 298]^{*T1. T2}

67 [15, 122]^{*T0. T3}

49 [8, 165]^*T0.T3

247 [152, 403]^{*T1. T2}

Bilirubin (mg/dl)

0.71 [0.28, 0.86]

0.46 [0.27, 0.79]

0.56 [0.30, 1.13]

0.67 [0.20, 1.22]

Creatinine (mg/dl)

0.77 [0.59, 1.26]

0.86 [0.54, 1.25]

0.79 [0.67, 0.97]

0.85 [0.63, 1.24]

INR

1.15 [1.04, 1.31]

1.14 [1.05, 1.30]

1.10 [1.03, 1.17]

1.09 [1.03, 1.14]

MELD score

9.7 [7.1, 22.8]

9.7 [7.2, 22.9]

8.4 [7.5, 21.9]

9.1 [7.3, 11.5]

AST (U/l)

36.5 [23.3, 90.3]

36.0 [26.5, 92.0]

33.0 [25.0, 58.0]

65.0 [44.3,103.5]

ALT (U/l)

29.0 [14.0, 78.0]

23.0 [13.5, 53.5]

19.0 [13.0, 30.0]

37.5 [25.3, 74.3]

AST/ALT ratio

1.14 [1.00, 1.89]

1.57 [0.92, 2.21]

1.56 [0.94, 2.21]

1.53 [1.05, 2.21]

Lactate (mmol/l)

1.13 [0.75, 1.31]

1.30 [0.86, 1.90]

1.39 [0.97, 1.78]

1.02 [0.87, 1.33]

Leucocytes (g/l)

9.9 [6.1, 18.3]

9.9 [8.5, 17.8]

12.5 [9.0, 14.3]

13.0 [9.0, 25.6]

Hemoglobin (g/l)

94 [90, 106]

89 [82, 102]

94 [82, 102]

87 [73, 95]

Hematocrit (%)

0.30 [0.27, 0.33]

0.28 [0.25, 0.31]

0.29 [0.27, 0.31]

0.27 [0.23, 0.30]

Thrombocytes (g/l)

216 [132, 271]

216 [97, 270]

225 [186, 303]

250 [217, 403]

MAP (mmHG)

77 [65, 85]

74 [71, 83]

77 [69, 91]

85 [69, 98]

Horowitz index

244 [173, 359]

283 [184, 336]

253 [189, 315]

240 [175, 333]

Noradrenalin

(µg kg⁻¹ min⁻¹)

0.096

[0.025, 0.130]

0.107

[0.055, 0.255]^*T3

0.100

[0.037, 0.194]^*T3

0.000

[0.000, 0.047] ^{*T1, *T2}

SOFA score

10.0 [8.8, 12.0]^*T3

10.5 [9.0, 12.3]^*T3

10.0 [9.0, 11.0]^*T3

8.0 [6.3, 10.0]^{*T0, T1, T2}