Impact of respiratory cycle during mechanical ventilation on beat-to-beat right ventricle stroke volume estimation by pulmonary artery pulse wave analysis

Intensive Care Medicine Experimental

Table 1 Respiratory and pulmonary hemodynamic variables during the studied situations

Variable	Baseline	ARDS	p
V_T (ml/kg)	8.48 [7.04–8.59]	8.52 [5.85–8.76]	0.500
RR (bpm)	32 (2)	33 (3)	0.570
PEEP (cmH₂O)	8.1 (0.1)	8.1 (0.2)	0.711
PPlat cmH₂O)	15.5 [12.9–15.7]	27.7 [26.9–29.9]	0.043
MAwP (cmH₂O)	10.9 (0.6)	14.4 (0.7)	< 0.001
DP (cmH₂O)	7.3 [4.9–7.5]	19.4 [18.8–22.2]	0.043
Cdyn (ml/cmH₂O)	39.5 (7.4)	11.8 (2.3)	0.002
SI	1.04 [0.95–1.06]	1.16 [1.16–1.16]	0.043
PaO₂ (mmHg)	541 (49)	196 (108)	0.005
PaCO₂ (mmHg)	42 (6)	59 (12)	0.019
SaO₂ (%)	98.8 (0.8)	95.8 (2.82)	0.069
pH	7.43 (0.06)	7.27 (0.06)	0.027
Shunt	0.09 (0.05)	0.25 (0.10)	0.060
CO (l/min)	3.19 [2.91–3.20]	2.71 [2.38–3.82]	0.500
HR (bpm)	96 (17)	107 (21)	0.257
PAPm (mmHg)	20 (2)	31 (6)	0.007
PVR (dyn.s.cm⁻⁵)	172 (65)	577 (156)	0.005
PA_Comp (ml/mmHg)	3.37 [3.10–5.65]	1.71 [1.35–2.04]	0.043

P values lower than 0.050 were higlighted in bold
Respiratory and hemodynamic variables at baseline and after acute respiratory distress syndrome (ARDS) was developed
V_t tidal volume, RR respiratory rate, SaO₂ arterial haemoglobin O₂ saturation, PEEP positive end expiratory pressure, PPlat plateau pressure, MAwP mean airway pressure, DP driving pressure (DP = PPlat-PEEP), Cdyn respiratory system dynamic compliance, SI stress index, CO cardiac output, HR heart rate, PAPm mean pulmonary artery pressure, PVR pulmonary vascular resistance, PA_Comp pulmonary artery compliance (stroke volume divided by pulmonary artery pulse pressure)