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Table 1 Parameters of oxygenation and microcirculation

From: Hyperoxemia and hypoxemia impair cellular oxygenation: a study in healthy volunteers

 

Baseline

Hypoxia

Washout

40%

60%

80%

100%

SpO2 (%)

100 (100–100)

80 (77–82)#

100 (100–100)

100 (100–100)

100 (100–100)

100 (100–100)

100 (100–100)

PaO2 (mmHg)

110 (99–110)

45 (38–50)

110 (110–130)

200 (200–210)*

300 (290–310)*

390 (360–390)*

390 ( 380–450)*

SaO2 (%)

99 (98–99)

83 (77–89)

99 (99–99)

100 (100–100)

100 (100–100)

100 (100–100)

100 (100–100)

Hb (g/dL)

12 (12–13)

13 (13–14)

13 (12–14)

13 (12–13)

13 (12–13)

13 (13–13)

13 (12–13)

Lactate (mmol/L)

0.60 (0.58–0.80)

0.80 (0.70–1.0)

0.55 (0.50–0.68)

0.60 (0.48–0.78)

0.50 (0.48–0.60)

0.50 (0.50–0.50)

0.50 (0.48–0.53)

pH

7.41 (7.38–7.59)

7.46 (7.41–7.59)

7.42 (7.39–7.47)

7.44 (7.41–7.52)

7.45 (7.42–7.57)

7.46 (7.42–7.52)

7.46 (7.42–7.47)

PaCO2 (mmHg)

36 (33–40)

33 (31–35)

38 (36–39)

35 (32–38)

33 (32–35)

34 (28–36)

34 (32–35)*

PPV (%)

96 (95–98)

95 (86–97)

–

–

–

–

83 (80–89)

Perfused DeBacker Density

3.6 (3.2–4.1)

3.8 (3.7–3.8)

–

–

–

–

2.4 (1.4–2.7)#

PPV small vessels (%)

100 (70–100)

100 (55–100)

–

–

–

–

75 (37–100)

Total vessel density

3.9 (3.3–4.3)

3.9 (3.7–4.2)

–

–

–

–

2.7 (1.7–3.3)

MitoPO2 (mmHg)

42 (35–51)

5.9 (4.3–9.0)#

39 (13–52)

20 (9.0–27)*

15 (13–32)*

18 (12–21)*

20 (15–25)

MitoVO2 (mmHg/s)

3.7 (2.9–5.0)

0.80 (0.50–1.0)#

3.2 (0.92–4.8)

2.0 (0.73–4.7)*

2.8 (1.7–4.4)

1.6 (0.77–3.2)*

2.4 (1.3–3.8)*

  1. PPV, proportion of perfused vessels
  2. *p < 0.05 compared to wash-out
  3. #p < 0.05 compared to baseline