From: Hyperoxemia and hypoxemia impair cellular oxygenation: a study in healthy volunteers
 | Baseline | Hypoxia | Washout | 40% | 60% | 80% | 100% |
---|---|---|---|---|---|---|---|
SpO2 (%) | 100 (100–100) | 80 (77–82)# | 100 (100–100) | 100 (100–100) | 100 (100–100) | 100 (100–100) | 100 (100–100) |
PaO2 (mmHg) | 110 (99–110) | 45 (38–50) | 110 (110–130) | 200 (200–210)* | 300 (290–310)* | 390 (360–390)* | 390 ( 380–450)* |
SaO2 (%) | 99 (98–99) | 83 (77–89) | 99 (99–99) | 100 (100–100) | 100 (100–100) | 100 (100–100) | 100 (100–100) |
Hb (g/dL) | 12 (12–13) | 13 (13–14) | 13 (12–14) | 13 (12–13) | 13 (12–13) | 13 (13–13) | 13 (12–13) |
Lactate (mmol/L) | 0.60 (0.58–0.80) | 0.80 (0.70–1.0) | 0.55 (0.50–0.68) | 0.60 (0.48–0.78) | 0.50 (0.48–0.60) | 0.50 (0.50–0.50) | 0.50 (0.48–0.53) |
pH | 7.41 (7.38–7.59) | 7.46 (7.41–7.59) | 7.42 (7.39–7.47) | 7.44 (7.41–7.52) | 7.45 (7.42–7.57) | 7.46 (7.42–7.52) | 7.46 (7.42–7.47) |
PaCO2 (mmHg) | 36 (33–40) | 33 (31–35) | 38 (36–39) | 35 (32–38) | 33 (32–35) | 34 (28–36) | 34 (32–35)* |
PPV (%) | 96 (95–98) | 95 (86–97) | – | – | – | – | 83 (80–89) |
Perfused DeBacker Density | 3.6 (3.2–4.1) | 3.8 (3.7–3.8) | – | – | – | – | 2.4 (1.4–2.7)# |
PPV small vessels (%) | 100 (70–100) | 100 (55–100) | – | – | – | – | 75 (37–100) |
Total vessel density | 3.9 (3.3–4.3) | 3.9 (3.7–4.2) | – | – | – | – | 2.7 (1.7–3.3) |
MitoPO2 (mmHg) | 42 (35–51) | 5.9 (4.3–9.0)# | 39 (13–52) | 20 (9.0–27)* | 15 (13–32)* | 18 (12–21)* | 20 (15–25) |
MitoVO2 (mmHg/s) | 3.7 (2.9–5.0) | 0.80 (0.50–1.0)# | 3.2 (0.92–4.8) | 2.0 (0.73–4.7)* | 2.8 (1.7–4.4) | 1.6 (0.77–3.2)* | 2.4 (1.3–3.8)* |