Table 1 General characteristics of the experimental animals

Gender (F/M)

3/2

3/2

4/3

4/4

Weight (kg)

57 (48.5–59.5)

56 (48.5–58)

52 (49–54)

49 (44–51)

Survival in 36 h of the experiment

5 (100%)

4 (80%)

4 (57%)

2 (25%)

Time T0 to death (min)

1800 (1800–1800)

2160 (1946–2325)#

1920 (1747–2160)

1703 (1440–1790)#

Time T0 to HA initiation (min)

1140 (900–1275)

N/A

1260 (1080–1395)

1200 (1035–1410)

Length of HA treatment (min)

600 (480–900)

N/A

690 (525–769)*

375 (330–503)*

Time T0 to NE (min)

970 (870–1215)

1200 (1143–1458)

1260 (1099–1398)

963 (763–1133)

Time from NE initiation to 0.3 μg/kg/min (min)

210 (145–1013)*

80 (68–165)

30 (20–51)*

144 (73–378)

Time from NE initiation to 0.5 μg/kg/min (min)

400 (299–1061)*

190 (174–246)

55 (41–66)*

205 (136–443)

Time from NE initiation to 1.0 μg/kg/min (min)

590 (369–1099)

360 (248–490)

210 (130–390)

330 (203–550)

Time from NE initiation to 3.0 μg/kg/min (min)

N/A

610 (440–940)

380 (278–607)

683 (393–1285)

NE average speed (μg/kg/min)

0.9 (0.4–1.5)*

2.3 (2.1–2.7)

3.7 (3.0–4.5)*

3.0 (1.4–6.7)

NE cumulative dose (μg/kg/h)

26.6 (8.2–49.0)

56.2 (46.4–62.5)

69.5 (61.3–98.2)

81.5 (34.4–138.3)

Diuresis (mL/kg/h)

1.4 (1.2–1.5)*

0.9 (0.6–1.0)

0.9 (0.8–1.0)

0.7 (0.6–0.9)*

Fluid intake (mL/kg/h)

9.7 (9.2–10.0)

10.3 (9.2–10.6)

10.1 (9.5–11.4)

10.3 (9.7–10.8)

Fluid balance (mL/kg/h)

8.3 (7.6–8.7)

9.4 (8.3–9.7)

9.4 (8.6–10.5)

9.4 (9.1–10.1)