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Table 4 Adjusted models for prediction of oxygenator change based on COHb

From: Carboxyhemoglobin predicts oxygenator performance and imminent oxygenator change in extracorporeal membrane oxygenation

Fixed-effects

Logistic regression model

Cox regression model

Estimate

Std. error

p-value

Estimate

Std. error

p-value

Intercept

4.50E−01

1.36E+00

< 0.0001

   

log(COHb)

8.08E−01

3.26E−01

0.013301

1.97E−01

2.46E−01

< 0.0001

Time, h

− 1.21E−02

4.15E−03

< 0.0001

   

LDH, U/L

3.40E−05

3.36E−05

0.31158

5.89E−05

5.10E−05

0.00236

Bilirubin, µmol/L

1.37E−03

9.39E−04

1.45E−01

1.72E−03

1.80E−03

0.00341

Hemoglobin, g/L

5.69E−07

9.21E−06

9.51E−01

− 3.50E−02

1.66E−02

< 0.0001

Sweep gas flow, L/min

1.07E−02

3.55E−02

7.63E−01

− 7.04E−03

4.31E−02

0.61313

Fibrinogen, g/L

− 7.75E−02

5.50E−02

1.59E−01

− 1.62E−01

7.93E−02

< 0.0001

D-dimer, mg/L

7.81E−02

2.30E−02

6.79E−04

6.27E−02

3.71E−02

0.03171

Blood flow, L/min

− 2.41E−01

9.17E−02

8.67E−03

− 6.27E−04

1.45E−02

0.89013

Lactate, mmol/L

1.16E−01

4.85E−02

1.64E−02

1.48E−03

4.16E−03

0.43365

Intercept

6.38E−03

3.34E−03

5.62E−02

1.13E−01

8.11E−02

< 0.0001

  1. Adjusted hierarchical generalized linear mixed-effects model of the binomial family (left) and hierarchical mixed-effects time-varying Cox proportional hazards model (right) of log(COHb) on oxygenator change within 6 h
  2. LDH lactate dehydrogenase