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Citation: Intensive Care Medicine Experimental 2024 12:43
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Lung behavior during a staircase high-frequency oscillatory ventilation recruitment maneuver
Lung volume optimization maneuvers (LVOM) are necessary to make physiologic use of high-frequency oscillatory ventilation (HFOV), but lung behavior during such maneuvers has not been studied to determine lung ...
Citation: Intensive Care Medicine Experimental 2024 12:42 -
Carboxyhemoglobin predicts oxygenator performance and imminent oxygenator change in extracorporeal membrane oxygenation
The continuous exposure of blood to a non-biological surface during extracorporeal membrane oxygenation (ECMO) may lead to progressive thrombus formation in the oxygenator, hemolysis and consequently impaired ...
Citation: Intensive Care Medicine Experimental 2024 12:41 -
Epstein–Barr virus, Cytomegalovirus, and Herpes Simplex-1/2 reactivations in critically ill patients with COVID-19
To assess the incidences of Herpes Simplex-1 and 2 (HSV-1, HSV-2), Cytomegalovirus (CMV), Epstein–Barr Virus (EBV) reactivations in critically ill COVID-19 patients. To determine the association between viral ...
Citation: Intensive Care Medicine Experimental 2024 12:40 -
Immediate inflammatory response to mechanical circulatory support in a porcine model of severe cardiogenic shock
In selected cases of cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is combined with trans valvular micro axial flow pumps (ECMELLA). Observational studies indicate that ECMELL...
Citation: Intensive Care Medicine Experimental 2024 12:39 -
Ineffectiveness of hemoadsorption in large animals with abdominal sepsis: a randomized controlled porcine study
The use of hemoadsorption (HA) has become popular in the treatment of vasoplegic states associated with massive cytokine release, including septic shock. However, this approach does not seem to be based on rob...
Citation: Intensive Care Medicine Experimental 2024 12:38 -
Hyperoxemia and hypoxemia impair cellular oxygenation: a study in healthy volunteers
Administration of oxygen therapy is common, yet there is a lack of knowledge on its ability to prevent cellular hypoxia as well as on its potential toxicity. Consequently, the optimal oxygenation targets in cl...
Citation: Intensive Care Medicine Experimental 2024 12:37 -
Oxygenation and ventilation during prolonged experimental cardiopulmonary resuscitation with either continuous or 30:2 compression-to-ventilation ratios together with 10 cmH20 positive end-expiratory pressure
In refractory out-of-hospital cardiac arrest, the patient is commonly transported to hospital with mechanical continuous chest compressions (CCC). Limited data are available on the optimal ventilation strategy...
Citation: Intensive Care Medicine Experimental 2024 12:36 -
The ongoing journey in targeting hemodynamic interventions: missing miles for missing the last micron?
Citation: Intensive Care Medicine Experimental 2024 12:35 -
Impact of respiratory cycle during mechanical ventilation on beat-to-beat right ventricle stroke volume estimation by pulmonary artery pulse wave analysis
The same principle behind pulse wave analysis can be applied on the pulmonary artery (PA) pressure waveform to estimate right ventricle stroke volume (RVSV). However, the PA pressure waveform might be influenc...
Citation: Intensive Care Medicine Experimental 2024 12:34 -
Isoflurane, like sepsis, decreases CYP1A2 liver enzyme activity in intensive care patients: a clinical study and network model
Liver function of intensive care patients is routinely monitored by static blood pathology. For specific indications, liver specific cytochrome activity may be measured by the commercially available maximum li...
Citation: Intensive Care Medicine Experimental 2024 12:33 -
Reinforcement learning for intensive care medicine: actionable clinical insights from novel approaches to reward shaping and off-policy model evaluation
Reinforcement learning (RL) holds great promise for intensive care medicine given the abundant availability of data and frequent sequential decision-making. But despite the emergence of promising algorithms, R...
Citation: Intensive Care Medicine Experimental 2024 12:32 -
Determinants of acute kidney injury during high-power mechanical ventilation: secondary analysis from experimental data
The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney f...
Citation: Intensive Care Medicine Experimental 2024 12:31 -
Flow-controlled ventilation decreases mechanical power in postoperative ICU patients
Mechanical power (MP) is the energy delivered by the ventilator to the respiratory system and combines factors related to the development of ventilator-induced lung injury (VILI). Flow-controlled ventilation (...
Citation: Intensive Care Medicine Experimental 2024 12:30 -
The ESICM datathon and the ESICM and ICMx data science strategy
Citation: Intensive Care Medicine Experimental 2024 12:29 -
Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis
Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predi...
Citation: Intensive Care Medicine Experimental 2024 12:28 -
Individualised flow-controlled ventilation reduces applied mechanical power and improves ventilation efficiency in a porcine intra-abdominal hypertension model
Aim of this study was to evaluate feasibility and effects of individualised flow-controlled ventilation (FCV), based on compliance guided pressure settings, compared to standard of pressure-controlled ventilat...
Citation: Intensive Care Medicine Experimental 2024 12:27 -
The association between coronary artery calcification and vectorcardiography in mechanically ventilated COVID-19 patients: the Maastricht Intensive Care COVID cohort
Coronary artery calcification (CAC) is associated with poor outcome in critically ill patients. A deterioration in cardiac conduction and loss of myocardial tissue could be an underlying cause. Vectorcardiogra...
Citation: Intensive Care Medicine Experimental 2024 12:26 -
Six methods to determine expiratory time constants in mechanically ventilated patients: a prospective observational physiology study
Expiratory time constant (τ) objectively assesses the speed of exhalation and can guide adjustments of the respiratory rate and the I:E ratio with the goal of achieving complete exhalation. Multiple methods of ob...
Citation: Intensive Care Medicine Experimental 2024 12:25 -
Glucocorticoid use in acute respiratory failure from pulmonary causes and association with early changes in the systemic host immune response
Glucocorticoids are commonly used in patients with or at-risk for acute respiratory distress syndrome (ARDS), but optimal use remains unclear despite well-conducted clinical trials. We performed a secondary an...
Citation: Intensive Care Medicine Experimental 2024 12:24 -
Can we rely on “calibrated” central venous pressure to measure pleural pressure at the bedside?
Citation: Intensive Care Medicine Experimental 2024 12:23 -
Esmolol increases the fecal abundance of Lactobacillus in a rat model of sepsis
Disorders of the gut microbiome could be responsible for the progression of multiple organ dysfunction syndrome. In this study, we examined the effect of esmolol on the gut microbiome in a rat model of sepsis ...
Citation: Intensive Care Medicine Experimental 2024 12:22 -
Development of personalized non-invasive ventilation masks for critically ill children: a bench study
Obtaining a properly fitting non-invasive ventilation (NIV) mask to treat acute respiratory failure is a major challenge, especially in young children and patients with craniofacial abnormalities. Personalizat...
Citation: Intensive Care Medicine Experimental 2024 12:21 -
Lung- and diaphragm-protective strategies in acute respiratory failure: an in silico trial
Lung- and diaphragm-protective (LDP) ventilation may prevent diaphragm atrophy and patient self-inflicted lung injury in acute respiratory failure, but feasibility is uncertain. The objectives of this study we...
Citation: Intensive Care Medicine Experimental 2024 12:20 -
BET-inhibitor DYB-41 reduces pulmonary inflammation and local and systemic cytokine levels in LPS-induced acute respiratory distress syndrome: an experimental rodent study
Acute respiratory distress syndrome (ARDS) is a form of respiratory failure stemming from various underlying conditions that ultimately lead to inflammation and lung fibrosis. Bromodomain and Extra-Terminal mo...
Citation: Intensive Care Medicine Experimental 2024 12:19 -
Association between intravenous fluid administration and endothelial glycocalyx shedding in humans: a systematic review
Several studies have demonstrated associations between greater rate/volume of intravenous (IV) fluid administration and poorer clinical outcomes. One postulated mechanism for harm from exogenous fluids is shed...
Citation: Intensive Care Medicine Experimental 2024 12:16 -
Sepsis and obesity: a scoping review of diet-induced obesity murine models
Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the “obesity paradox...
Citation: Intensive Care Medicine Experimental 2024 12:15 -
Correspondence regarding the article by Murugan et al. on “Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach”
Citation: Intensive Care Medicine Experimental 2024 12:18 -
Response Letter to: Correspondence regarding the article by Murugan et al on Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach
Citation: Intensive Care Medicine Experimental 2024 12:17 -
The impact of ECPELLA on haemodynamics and global oxygen delivery: a comprehensive simulation of biventricular failure
ECPELLA, a combination of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) and Impella, a percutaneous left ventricular (LV) assist device, has emerged as a novel therapeutic option in patients wi...
Citation: Intensive Care Medicine Experimental 2024 12:13 -
HS-GC–MS analysis of volatile organic compounds after hyperoxia-induced oxidative stress: a validation study
Exhaled volatile organic compounds (VOCs), particularly hydrocarbons from oxidative stress-induced lipid peroxidation, are associated with hyperoxia exposure. However, important heterogeneity amongst identifie...
Citation: Intensive Care Medicine Experimental 2024 12:14 -
Mesenchymal stem cells-based therapies for severe ARDS with ECMO: a review
Acute respiratory distress syndrome (ARDS) is the primary cause of respiratory failure in critically ill patients. Despite remarkable therapeutic advances in recent years, ARDS remains a life-threatening clini...
Citation: Intensive Care Medicine Experimental 2024 12:12 -
Positive end-expiratory pressure limits inspiratory effort through modulation of the effort-to-drive ratio: an experimental crossover study
How assisted spontaneous breathing should be used during acute respiratory distress syndrome is questioned. Recent evidence suggests that high positive end-expiratory pressure (PEEP) may limit the risk of pati...
Citation: Intensive Care Medicine Experimental 2024 12:10 -
Validation of a low-cost continuous renal replacement therapy dialysate fluid controller for experimental purposes
Continuous renal replacement therapy (CRRT) support is crucial for critically ill patients and it is underexplored in specific situations. Experimental CRRT offers a means to gain insights into these scenarios...
Citation: Intensive Care Medicine Experimental 2024 12:9 -
Understanding the pathophysiology of acute critical illness: translational lessons from zebrafish models
The models used to investigate the pathophysiological mechanisms of acute critical illness are not limited to mammalian species. The zebrafish (Danio rerio) is a popular model organism for studying diseases due t...
Citation: Intensive Care Medicine Experimental 2024 12:8 -
Recombinant antithrombin attenuates acute kidney injury associated with rhabdomyolysis: an in vivo animal study
Rhabdomyolysis is characterized by the destruction and necrosis of skeletal muscle tissue, resulting in acute kidney injury (AKI). Recombinant antithrombin (rAT) has DNA repair and vascular endothelial-protect...
Citation: Intensive Care Medicine Experimental 2024 12:7 -
Estimation of normal lung weight index in healthy female domestic pigs
Lung weight is an important study endpoint to assess lung edema in porcine experiments on acute respiratory distress syndrome and ventilatory induced lung injury. Evidence on the relationship between lung–body...
Citation: Intensive Care Medicine Experimental 2024 12:6 -
Validation of an alternative technique for RQ estimation in anesthetized pigs
Respiratory quotient (RQ) is an important variable when assessing metabolic status in intensive care patients. However, analysis of RQ requires cumbersome technical equipment. The aim of the current study was ...
Citation: Intensive Care Medicine Experimental 2024 12:11 -
Current clinical practice in using adjunctive extracorporeal blood purification in sepsis and septic shock: results from the ESICM “EXPLORATION” survey
Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis a...
Citation: Intensive Care Medicine Experimental 2024 12:5 -
Estimating the change in pleural pressure using the change in central venous pressure in various clinical scenarios: a pig model study
We have previously reported a simple correction method for estimating pleural pressure (Ppl) using central venous pressure (CVP). However, it remains unclear whether this method is applicable to patients with ...
Citation: Intensive Care Medicine Experimental 2024 12:4 -
Immunophenotyping patients with sepsis and underlying haematological malignancy reveals defects in monocyte and lymphocyte function
Citation: Intensive Care Medicine Experimental 2024 12:3 -
Doxycycline reduces liver and kidney injuries in a rat hemorrhagic shock model
Hemorrhagic shock (HS), which causes insufficient tissue perfusion, can result in multiple organ failure (MOF) and death. This study aimed to evaluate whether doxycycline (DOX) protects cardiovascular, kidney,...
Citation: Intensive Care Medicine Experimental 2024 12:2 -
Mastering the brain in critical conditions: an update
Acute brain injuries, such as traumatic brain injury and ischemic and hemorragic stroke, are a leading cause of death and disability worldwide. While characterized by clearly distict primary events—vascular da...
Citation: Intensive Care Medicine Experimental 2024 12:1 -
Metabolic disturbances potentially attributable to clogging during continuous renal replacement therapy
Clogging is characterized by a progressive impairment of transmembrane patency in renal replacement devices and occurs due to obstruction of pores by unknown molecules. If citrate-based anti-coagulation is use...
Citation: Intensive Care Medicine Experimental 2023 11:99 -
The effect of inspiratory rise time on mechanical power calculations in pressure control ventilation: dynamic approach
Mechanical power may serve as a valuable parameter for predicting ventilation-induced injury in mechanically ventilated patients. Over time, several equations have been developed to calculate power in both vol...
Citation: Intensive Care Medicine Experimental 2023 11:98 -
A model of hemodialysis after acute kidney injury in rats
Acute kidney injury (AKI) is frequent among critically ill patients. Renal replacement therapy (RRT) is often required to deal with severe complications of AKI. This technique is however associated with side e...
Citation: Intensive Care Medicine Experimental 2023 11:97 -
Capillary leak and endothelial permeability in critically ill patients: a current overview
Capillary leak syndrome (CLS) represents a phenotype of increased fluid extravasation, resulting in intravascular hypovolemia, extravascular edema formation and ultimately hypoperfusion. While endothelial perm...
Citation: Intensive Care Medicine Experimental 2023 11:96 -
Publisher Correction: ESICM LIVES 2023
Citation: Intensive Care Medicine Experimental 2023 11:95 -
Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury
Side effects of mechanical ventilation, such as ventilator-induced diaphragmatic dysfunction (VIDD) and ventilator-induced lung injury (VILI), occur frequently in critically ill patients. Phrenic nerve stimula...
Citation: Intensive Care Medicine Experimental 2023 11:94 -
Pressure-support compared with pressure-controlled ventilation mitigates lung and brain injury in experimental acute ischemic stroke in rats
We aimed to evaluate the pulmonary and cerebral effects of low-tidal volume ventilation in pressure-support (PSV) and pressure-controlled (PCV) modes at two PEEP levels in acute ischemic stroke (AIS).
Citation: Intensive Care Medicine Experimental 2023 11:93
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- ISSN: 2197-425X (electronic)