0894. Time course of VILI development: a CT scan study
© Chiurazzi et al; licensee Springer. 2014
Published: 26 September 2014
Mechanical Ventilation at high tidal volumes and pressures induces in lung oedema which is undistinguishable from ARDS. It is possible that pleura, bronchi and vessels act as a natural stress raiser playing as local stress multipliers. 
To study the development of VILI with CT scan and determine where and when the first lesions appear and to follow their development in time.
Piglets were instrumented and ventilated with TV of corresponding to a strain (TV/FRC) >2.5. The whole study was performed in an animal CT scan facilities equipped as an ICU. Every three hours a CT scan was performed and data on respiratory mechanics were collected. CT scans were analysed and lesions were defined as clearly defined regions of poorly/not inflated tissue (-500/+100 HU) with a minimal diameter of 6 mm non present in the previous CT scan image. Lung weight was computed from the CT scan data.
Oxygenation and respiratory mechanics impairment is evident when relevant lung oedema develops. Most of the first CT scan lesions are located in lung regions which act as stress raisers and precede alterations in gas exchange and respiratory mechanics.
ESICM Bernard Drager Award 2012 to M.C.
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