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0714. Interaction between adipokines and the metabolic stress response: angpt l2 cxcl5 and visfatin in patients undergoing cardiac surgery
Intensive Care Medicine Experimental volume 2, Article number: P46 (2014)
Adipose tissue plays an intriguing role in the endocrine system by producing adipokines . In patients with obesity, metabolic syndrome, and type 2 diabetes (DM2), insulin resistance is influenced by adipokines .
From a metabolic point of view, the stress response caused by surgical injury imitates the diabetic state. Stereotypical endocrine-metabolic and inflammatory reactions result in catabolism and pronounced insulin resistance, which is related to outcome .
Three adipokines including angiopoietin-like protein 2 (ANGPTL2), CXC-chemokine ligand 5 (CXCL5), and Visfatin that are known to interact with insulin resistance  were evaluated in patients undergoing cardiac surgery.
Sixty-six patients scheduled for elective aortocoronary bypass surgery and/or valve repair were consecutively enrolled receiving standardized perioperative care. Serum adipokine concentrations were assessed before anesthesia induction as baseline values, upon arrival on the intensive care unit, on the first (POD1) and third (POD3) day postoperatively.
Patients' baseline characteristics are shown in table 1. ANGPTL2 increased from baseline until POD1 and remained elevated on POD3 (table 2). In contrast, CXCL5 levels decreased during surgery and returned to baseline by POD3. Visfatin levels increased during surgery, showed a decrease by POD1 only to increase again by POD3. DM2 patients appear to exhibit a marked Visfatin increase during surgery, as well as a pronounced increase in CXCL5 from POD1 to POD3.
This exploratory study assessed for the first time the perioperative levels of ANGPTL2, CXCL5, and Visfatin. Further studies are warranted to correlate adipokine concentrations with insulin resistance and surgical outcomes and to investigate the potential role of adipokines as biomarkers or therapeutic targets.
Ouchi N, et al.: Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011, 11: 85–97. 10.1038/nri2921
Coursin DB, et al.: Perioperative diabetic and hyperglycemic management issues. Crit Care Med 2004, 32: S116–25. 10.1097/01.CCM.0000115623.52021.C0
Research Fond, Department of Anesthesia and Surgical Intensive Care, University Hospital Basel, Switzerland.
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Meyer, T., Nitschmann, E., Schurr, U. et al. 0714. Interaction between adipokines and the metabolic stress response: angpt l2 cxcl5 and visfatin in patients undergoing cardiac surgery. ICMx 2 (Suppl 1), P46 (2014). https://doi.org/10.1186/2197-425X-2-S1-P46
- Insulin Resistance
- Metabolic Stress
- Anesthesia Induction
- CXCL5 Level
- Aortocoronary Bypass