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Effect of peep on esophageal catheter optimal calibration volume and esophageal pressure measurements
Intensive Care Medicine Experimental volume 3, Article number: A1001 (2015)
The use of esophageal balloon catheter to estimate pleural pressure has gained renewed popularity in recent years. Indeed, measurement of transpulmonary pressure may allow a more pathophysiological-based approach to ventilator strategy in ARDS patients. Nevertheless it is well known that esophageal balloon catheter derived parameters can be influenced by several patient-related or technical-related factors.
To evaluate in-vivo the effect of positive end-expiratory pressure (PEEP) variations on esophageal catheter optimal calibration volume and measured esophageal pressure.
Experimental study in 8 (5 ARDS, 3 control) sedated, intubated, paralyzed and mechanically ventilated (volume-control) patients. Patients were monitored with esophageal balloon catheter (Cooper Surgical, Trumbull, CT USA).
Three PEEP groups were defined: lowPEEP (8 and 4 cmH2O respectively in ARDS and control patients), mediumPEEP (12 and 8 cmH2O) and highPEEP (16 and 12 cmH2O).
During each PEEP level, we inflated the esophageal balloon with increasing amount of air (from 0.2 to 2 ml). For each injected volume, we performed an end-inspiratory occlusion maneuver followed by an occlusion test by applying manual chest compression during an end-expiratory airway occlusion maneuver. We measured the ratio between airway pressure variation and esophageal pressure variation (ΔPaw/ΔPes ratio) during the occlusion test, end-expiratory esophageal pressure (Pes,e), end-expiratory transpulmonary pressure (Pl,e), chest wall compliance (CplCW), lung compliance (CplL), elastance-derived transpulmonary plateau pressure (ΔPl,i). The optimal calibration volume (defined as the injected volume at which ΔPaw/ΔPes ratio was closer to 1) was identified for each PEEP group (VCLPEEP for lowPEEP, VCMPEEP for mediumPEEP, VCHPEEP for highPEEP). Effect of PEEP on derived parameters was assessed by comparing at PEEP medium and high values obtained at the VCLPEEP against values obtained with the optimal VC at each PEEP.
Optimal calibration volumes progressively raised with increasing PEEP (0.95 ± 0.14 ml, 1.1 ± 0,18 ml, 1.22 ± 0.2 ml respectively for lowPEEP, mediumPEEP and highPEEP; p< 0.001). See Figure 1. At high PEEP, Pes,e, CplL and ΔPl,i were significantly higher while Cplcw was significantly lower e when measured with VCHPEEP compared to VCLPEEP.
Partitioned respiratory system mechanic parameters are show in Table.
Esophageal catheter balloon calibration volume is affected by PEEP. Neglecting this effect may leads to errors in computing partitioned respiratory system mechanics. Catheter calibration should be checked after every change in PEEP.
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Chiumello D, et al: Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. Am J Respir Crit Care Med. 178: 346-55.
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Magni, F., Ceriani, D., Castagna, L. et al. Effect of peep on esophageal catheter optimal calibration volume and esophageal pressure measurements. ICMx 3, A1001 (2015). https://doi.org/10.1186/2197-425X-3-S1-A1001
- Chest Compression
- Transpulmonary Pressure
- Esophageal Pressure
- Occlusion Test
- Chest Wall Compliance