Skip to main content

Volume 3 Supplement 1


Highly sensitive troponin t (hstnt) profile for outcome prediction after cardiac surgery


Changes in cardiac mediators remain a subject of research interest. Instantly obtainable biomarkers that are performed routinely, are inexpensive and are characterized by linkages to outcome in cardiac surgery settings are optimum. Post-operative conventional cardiac troponins are linked to short- and middle-length outcomes [1] but highly sensitive troponin T (hsTnT) has not been extensively evaluated in the same settings.


To assess the ability of hsTnT to prognosticate outcomes in cardiac surgery.


We conducted a single-center, prospective observational study over 2 years. We analyzed the data from all patients who underwent cardiac surgery. We recruited 413 patients with a mean age of 54.9 ± 10.9 years. The patients were divided into two groups based on hsTnT level, which is analogous to creatine kinase MB (CK-MB) and indicates myocardial injury (with and without myocardial infarction) [2]. The receiver operator curve (ROC) was used to determine this relation, retrieving a level of 2309 ng/L and showing an 80% sensitivity and an 86% specificity (figure). We used a t-test to compare variables and multivariate analysis was conducted for significant variables.

Figure 1
figure 1

ROC for hsTnT associated with a high CK-MB.


Two groups (group A (372 patients) and group B (41 patients)) were both matched for age, body mass index, diabetes mellitus association, serum creatinine, Euroscore, aortic cross clamp and cardiopulmonary bypass time, and total length of anesthesia. Patients with hsTnT levels of 2309 ng/L or lower had a better outcome in terms of inotropes need, lengths of ventilation (LOV), ICU and hospital stay, and post-operative complications. Multivariate analysis revealed significant relations of the given level with operative emergency (p = 0.001); the level was a predictor for a longer duration of mechanical ventilation (p = 0.01) and post-operative atrial fibrillation (POAF) (p = 0.003) (Table 1). Moreover, 9 patients (21.9%) in group B had perioperative myocardial infarctions.

Table 1 Multivariate logistic regression for hsTnT.


Outcome prediction in cardiac surgery in terms of PMI, LOV and POAF could be enhanced by using a set level of hsTnT; this profile serves as a powerful laboratory marker to identify high-risk patients.

Grant Acknowledgment

We thank all members of cardiothoracic surgery department and the medical research center of Hamad medical corporation.


  1. Buse GAL, Koller MT, Grapow M, et al: The prognostic value of troponin release after adult cardiac surgery. A meta-analysis. Eur J Cardiothorac Surg. 2010, 37 (2): 399-406.

    Google Scholar 

  2. Thygesen K, Alpert JS, Jaffe , et al: Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Third universal definition of myocardial infarction. Eur Heart J. 2012, 33 (20): 2551-67. 10.1093/eurheartj/ehs184.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Omar, A., Sudarsanan, S., Hanoura, S. et al. Highly sensitive troponin t (hstnt) profile for outcome prediction after cardiac surgery. ICMx 3 (Suppl 1), A108 (2015).

Download citation

  • Published:

  • DOI: