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Volume 3 Supplement 1

ESICM LIVES 2015

  • Poster presentation
  • Open Access

Risk factors for colonization and infection by multiresistant bacteria

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Intensive Care Medicine Experimental20153 (Suppl 1) :A126

https://doi.org/10.1186/2197-425X-3-S1-A126

  • Published:

Keywords

  • Intensive Care Unit
  • Chronic Obstructive Pulmonary Disease
  • Renal Failure
  • Pulmonary Disease
  • General Hospital

Introduction

In 2013, the “Zero Resistance” (RZ) program was launched in Spain, to help prevent the emergence of multiresistant bacteria (MRB) in critically ill patients. One of its recommendations is to complete a checklist upon patient admission in Intensive Care Unit (ICU) to identify those patients at high risk for colonization or infection by MRB*.

Objectives

To analyse the effectiveness of the checklist proposed as a way to early detect MRB and the role of other comorbidities.

Methods

A prospective study from March 17th, 2014 to January 31rst, 2015. All patients admitted to a polyvalent ICU of a general hospital were submitted to the checklist proposed, with the application of contact precaution (CP) strategies for patients with risk factors (RF) for colonization or infection by MRB. Bacteriologic swabs (nasal, pharyngeal, axillary and rectal) were routinely performed on all patients admitted, besides diagnostic cultures when they were necessary. Furthermore, we analysed other pathological variables and comorbidities (diabetes, renal failure, immunosuppression state, neoplasia, cirrhosis, chronic obstructive pulmonary disease -COPD-, organ transplantation, malnutrition and type of admission to ICU - urgent or programmed). Univariate and multivariate analysis of risk factors for MRB with binary logistic regression were performed. Statistical significance was set at CI 95%.

Results

780 patients were admitted. 231 (29,6%) met some CP criteria. In 78 (10%) were detected one or more MRB, 49 of these (62,8%) presented CP criteria according to the checklist. 23 met 1 criteria, 17 met 2 criteria and 10 met 3 or more criteria with accumulation of risk. In 29 (37, 2%) MRB carriers it was not identified any of the RF from the checklist. Tables 1 and 2 show RF and comorbidities that were significant as added risk for MRB. We did not find significant relation between renal failure, immunosuppression state, neoplasia, cirrhosis or organ transplantation and being MRB carrier.
Table 1

RZ checklist.

RZ CHECK LIST

OR (IC 95%) UNIVARIATE

OR (IC 95%) MULTIVARIATE

Hospitalization >5 days in prior 3 months

3,2 (2,0-5,2)

2,05 (1,1-3,7)

Institutionalized patient

3,7 (1,6-8,6)

NS

Prior MRB colonization/infection

14 (5,7-34,4)

8,7 (3,3-22,9)

Antibiotherapy >7 days in prior month

4,2 (2,5-7,2)

2,1 (1,1-4,1)

Chronic kidney disease with dialysis

1,5 (0,2-12,7)

NS

Colonization susceptibility (bronchiectasis, cystic fibrosis)

2,0 (0,7-5,5)

NS

Table 2

Comorbidities and type of admission.

COMORBIDITY

OR (IC 95%) UNIVARIATE

OR (IC 95%) MULTIVARIATE

DM type II

1,9 (1,2-3,1)

1,8 (1,1-3,1)

COPD

1,9 (1,1-3,4)

NS

Malnutrition

1,9 (1,1-3,6)

NS

Urgent admission to ICU

1,85 (1,1-3,0)

NS

Conclusions

In our environment, the checklist did not detect 37% of patients with MRB. Prior antibiotic therapy and prior colonization were the best predictors. Further factors as diabetes could help on detection of MRB in ICU.

Authors’ Affiliations

(1)
Hospital Universitari Arnau de Vilanova, Lleida, Spain
(2)
Hospital Universitari Arnau de Vilanova., Lleida, Spain

References

  1. Montero J, et al: (Scientific Expert Committee for the “Zero Resistance” Project). Combatting resistance in intensive care: the multimodal approach of the Spanish ICU “Zero Resistance” program. Critical Care. 2015, 19 (114):Google Scholar

Copyright

© Carvalho Brugger et al.; 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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