- Poster presentation
- Open Access
Changes in blood glucose concentrations over time when administering intravenous insulin in post cardiac surgery in adult intensive care patients
© Bass et al.; 2015
- Published: 1 October 2015
- Blood Glucose
- Blood Glucose Concentration
- Insulin Infusion
- Continuous Glucose Monitoring
- Continuous Glucose Monitoring System
Patients in intensive care units (ICUs) are treated with intravenous (IV) insulin by infusions with the goal of maintaining blood glucose (BG) within a narrow target range. However, as BG is measured intermittently and how the time course of BG concentration changes after altering the insulin infusion rate is unknown. We used an intra-arterial Continuous Glucose Monitoring (CGM) system to study the time course of BG concentrations after changes in IV insulin infusion rates.
This prospective, observational cohort study was conducted during Feb-April 2013 as part of a CGM product development study. Following local human research ethics approval we studied adult patients admitted to our ICU immediately after elective, cardiac surgery who received an IV insulin infusion as clinically indicated. Prior written consent was obtained from all participants prior to surgery. All BG concentrations were measured for up to 48hrs using a CGM system via the radial artery catheter. The CGM system recorded BG values every 10 seconds. Insulin (Actrapid) was infused at a concentration of I unit/5mls via a volumetric pump. We analysed BG values measured by the CGM system following a step-wise change in the insulin infusion rate for a maximum of 2 hours. Infusion rate changes analysed were (1 u/hr increase, 1 u/hr decrease, 2 u/hr increase,and 2 u/hr decrease).We excluded artefactual measurements that occurred due to blood draws or flushing though the arterial line. Linear interpolation was used to estimate excluded data.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.