Skip to main content

Volume 3 Supplement 1


Lactate as prognostic factor after out-of-hospital cardiac arrest treated by therapeutic hypothermia


Out-of-hospital cardiac arrest (OHCA) is a major public health problem whose prognosis is uncertain. Therapeutic hypothermia improved outcome of these patients but also changed the value of several prognosis factors [1, 2]. Lactate is a controversial factor associated to outcome after OHCA [3].


Evaluation of lactate as prognosis factor after out-of-hospital cardiac arrest treated by therapeutic hypothermia


We performed a retrospective study including adult patients admitted in 4 ICUs for OHCA and treated by therapeutic hypothermia. We collected demographic data, circumstances of cardiac arrest and arterial lactate levels in the first 48 hours after admission. Neurologic outcome was evaluated by the CPC score: favorable outcome (scores 1-2) and unfavorable outcome (scores 3-5). Data are expressed as median and IQR. Comparisons were made by a Mann-Whitney or a chi-squared tests as appropriate. Odds ratio associated to outcome were estimated by a logistic regression. A p value < 0.05 was considered as statistically significant.


Two-hundred and seventy-two patients were included in the study: 89 favorable and 183 unfavorable outcome patients. Favorable outcome patients were younger (60 [49-70] vs. 68 [58-76] years; p < 0.01), exhibited shorter durations of no-flow (1 [0-5] vs. 5 [0-10] min; p < 0.01) and low-flow (10 [5-15] vs. 20 [15-30] min; p < 0.01), and a higher proportion of shockable rhythm (74% vs. 30%; p < 0.01). Lactate levels at different times were lower in the favorable outcome patients (table 1).

Table 1 Lactate levels according to outcome.

In multivariate analysis, several factors were associated to unfavorable outcome: admission lactate levels (OR 1.304 [1.146-1.483] p < 0.01), age (OR 1.031 [1.01-4.55] p < 0.01), non-shockable rhythm (OR 1.993 [1.039-3.825] p < 0.01). Outcome was different according to quartiles of lactate (p < 0.01; figure).

Figure 1
figure 1

Outcome according to quartiles of lactate.


Lactate levels seem associated to outcome after OHCA treated by therapeutic hypothermia. However, the statistical performance of this test alone is insufficient to establish a neurologic prognosis. Prospective studies associating several parameters are needed to improve prognostication.


  1. Neurology. 2006, 67: 203-10.

  2. Resuscitation. 2010, 81: 1219-76.

  3. Resuscitation. 2013, 84: 1078-82.

Download references

Author information

Authors and Affiliations


Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Orban, J., Novain, M., Cattet, F. et al. Lactate as prognostic factor after out-of-hospital cardiac arrest treated by therapeutic hypothermia. ICMx 3 (Suppl 1), A200 (2015).

Download citation

  • Published:

  • DOI: