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- Open Access
Arterial oxygenation and mortality in patients admitted to intensive care following out-of-hospital cardiac arrest
© Ahmed et al.; 2015
- Published: 1 October 2015
- Intensive Care Unit
- Cardiac Arrest
- Hospital Discharge
- Hospital Mortality
- Arterial Oxygenation
The effects of hyperoxia at a cellular level are well known, with formation of free radical species causing reactive damage. It has previously been shown that hyperoxia is associated with increased mortality in patients resuscitated from cardiac arrest . However, hypoxia is likewise deleterious to outcomes in this patient cohort.
We sought to examine whether mortality varies with arterial oxygenation in the first 24 hours after admission to our intensive care unit (ICU) following out of hospital cardiac arrest (OOHCA).
This was a retrospective, consecutive case series of patients admitted to the ICU at the Victoria Infirmary, Glasgow following OOHCA over a 15 year period between 1999 and 2014. Patients were identified and characterised using the WardWatcher™ database. Three subgroups were generated based on the arterial partial pressure of oxygen (Pa02) provided as part of severity scoring: hyperoxia was defined as Pa02 > 15, normoxia as Pa02 10-15 and hypoxia as Pa02 < 10 kPa. Hospital mortality was the primary outcome measure and statistical significance was assessed using Fisher's exact test.
Prevalence & mortality in art. oxygenation subsets.
Number (%) of patients
There was no statistically significant difference in hospital mortality between groups (P = 1.0 for hyperoxia vs. normoxia; P = 0.68 for normoxia vs. hypoxia).
We demonstrated survival to hospital discharge in almost a quarter of patients admitted to ICU post-OOHCA. Despite international resuscitation guidelines to the contrary , a significant proportion of our patients continue to be exposed to hyperoxia. However, there is no evidence that arterial oxygenation levels impact outcomes in our unit.
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