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Extra vascular lung water but not lung ultrasound predicts grade 3 pulmonary graft dysfunction and utilization of rescue therapies for severe hypoxemia after lung transplantation
Intensive Care Medicine Experimental volume 3, Article number: A233 (2015)
Primary graft dysfunction (PGD) is the result of pulmonary edema following lung transplantation. The definition  is based on Pa02/Fi02 and the presence of lung infiltrates on chest X-ray. Lung ultrasonography (LUS) and the extravascular lung water index (EVLWi) are reliable methods for quantification of lung edema [2, 3].
We tested if LUS and EVLWi were associated with grade 3 PGD.
We prospectively included patients who underwent lung transplantation in one university teaching hospital over a 14-month period. LUS scores and EVLWi were assessed at ICU admission and during the following 48 hours period. We compared patients with grade 3 PGD with the others.
36 patients were included. Among them, 13 (36 %) had grade 3 PGD. EVLWi was significantly higher in the grade 3 PGD group at ICU admission, day one and at day 2.
A cut-off value of 14 ml/kg of EVLWi at admission predicts the progression to grade 3 PGD with a sensitivity of 82% and a specificity of 77% and was significantly associated with the need for rescue therapy for severe hypoxemia.
Less than a half of patients had all their LUS windows available. LUS scores did not discriminate patients with grade 3 PGD from the others.
Contrary to LUS scores, EVLWi is a promising tool for early assessment of grade 3 PGD after lung transplantation.
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Guervilly, C., Lehingue, S., Dizier, S. et al. Extra vascular lung water but not lung ultrasound predicts grade 3 pulmonary graft dysfunction and utilization of rescue therapies for severe hypoxemia after lung transplantation. ICMx 3, A233 (2015) doi:10.1186/2197-425X-3-S1-A233
- Pulmonary Edema
- Lung Transplantation
- Rescue Therapy
- Lung Edema
- Extravascular Lung Water