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Volume 3 Supplement 1

ESICM LIVES 2015

Impact of oncologic pathology (OP) in the evolution of severe sepsis (SS) in the critically ill patients (CIP)

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Intr

It is considered that the severity of septic CIPs is higher than the overall CIPs requiring ICU admission. Nevertheless, the impact of the OP over the severity of the SS perhaps has not been sufficiently analyzed and evaluated.

Objectives

To evaluate the impact of the OP in the evolution of the SS of the CIPs.

Methods

· Study: prospective, analytical, longitudinal, and observational

  • · Period: January 1-2011 / June 30-2014 (42 months)

  • · SETTING. Medical/Surgical ICU

  • · Population: 2559 CIPs admitted consecutively to the ICU; sample: 484 CIPs with SS.

· Exclusión criteria: CIPs < 16 y., major burn CIPs, incomplete clinical documentation, and voluntary discharge.

· Variables analyzed:

a) Age

b) Hospital mortality

c) Case - mix: metabolic acidosis, total parenteral nutrition, intra-abdominal pressure (IAP), blood products, cultures, cardiac output, renal replacement therapy (RRT), advanced life support (ALS), FGC, FBC,

e) Organ dysfunction: SOFA and LODS

f) Limitation of life support (LLS).

· Statistical analysis: Ji squared and contrast of means (Student's t)

· Limitations of the study: absence of critically burned patients and pediatric CIPs

Results

Global CIPs: 2559; sepsis CIPs: 484; non sepsis CIPs: 2075

SOFA: Global (2.70), septic CIPs (5,32), non-septic CIPs (1,90)

LODS: Global (1.37), septic CIPs (2,78), non-septic CIPs (0,94)

See Tables 1 and 2.

Table 1 Table 1
Table 2 Table 2

Conclusions

1) The OP conditions not age or mortality of CIPs with SS.

2) Metabolic acidosis and the need of TPN, IAP and blood products are higher in the SS with OP.

3) Cultures, RRT, ALS, FGC, and FBC are applied equally in both groups.

4) The LLS is applied more in the SS with OP.

References

  1. 1.

    Phillips R, Hancock B, Graham J, Bromham N, Jin H, Berendse S: Prevention and management of neutropenic sepsis in patients with cancer: summary of NICE guidance. BMJ. 2012, 345: e5368-

  2. 2.

    Corcuera Romero de la Devesa R, Ruiz Moreno J, González Marín E, Esteve Paños MJ, Godayol Arias S, Conesa Folch N, Rinaudo Videla M, Artigas Raventós A: Evaluation of severity in critically ill patientes (CIPS) with sepsis. European Society of Intensive Care Medicine, 27th Annual Congres. 2014, Barcelona, Spain, September

  3. 3.

    Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R: Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012. JAMA. 2014, 311 (13): 1308-1316.

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Author information

Correspondence to J Ruiz Moreno.

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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Ruiz Moreno, J., González Marín, E., Esteve Paños, M. et al. Impact of oncologic pathology (OP) in the evolution of severe sepsis (SS) in the critically ill patients (CIP). ICMx 3, A247 (2015) doi:10.1186/2197-425X-3-S1-A247

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Keywords

  • Public Health
  • Cardiac Output
  • Replacement Therapy
  • Severe Sepsis
  • Renal Replacement Therapy