- Poster presentation
- Open Access
Elevated endocan levels are associated with development of renal failure in ARDS patients
© Rahmania et al.; 2015
- Published: 1 October 2015
- Chronic Kidney Disease
- Renal Replacement Therapy
- Acute Kidney Injury
- Acute Respiratory Distress Syndrome
Endocan is a proteoglycan preferentially expressed in pulmonary and renal vasculatures and a marker of endothelial dysfunction . Recently, elevated plasma endocan concentrations have been associated with chronic kidney disease stage after renal transplantation , but data on acute kidney injury are lacking.
The aim of the study was to determine whether plasma endocan levels were correlated with renal function in patients with acute respiratory distress syndrome (ARDS) and could predict the need for renal replacement therapy (RRT), as an indicator of acute renal dysfunction, during the ICU stay.
This was a post hoc analysis of prospectively collected data from 96 consecutive patients with ARDS (Berlin definition) who were not receiving RRT at diagnosis. Plasma endocan concentrations were measured using a quantitative ELISA method (Lunginov, France). We analyzed the predictive value of creatinine and endocan levels at diagnosis on the subsequent need for RRT using the area under the receiver operating characteristic curve (ROC AUC). We dichotomized values of creatinine (using a renal SOFA cut-off of 1.2 mg/dL) and endocan (best sensitivity and specificity based on the ROC curve) to predict need for RRT. All analyses were performed using SPSS 22.0 and a p value < 0.05 was considered as significant. Al values are presented as median with p25-75.
At ARDS diagnosis, elevated endocan levels are associated with subsequent development of renal failure.
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