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Volume 3 Supplement 1


  • Poster presentation
  • Open Access

A retrospective evaluation of acute kidney injury and effects of renal replacement therapy in septic or nonseptic critically ILL patients

  • 1,
  • 1,
  • 1,
  • 2,
  • 1,
  • 1 and
  • 1
Intensive Care Medicine Experimental20153 (Suppl 1) :A265

  • Published:


  • Glomerular Filtration Rate
  • Septic Shock
  • Renal Replacement Therapy
  • Acute Kidney Injury
  • Glasgow Coma Score


Acute kidney injury (AKI) is characterized with decline in the glomerular filtration rate, elevation of serum blood urea nitrogen, creatinine, and other metabolic waste products [1]. AKI is considered to be associated with sepsis between 45 to 70% [2].


The aim of the study was to investigate the variabilities in vital signs, hemodynamic parameters and laboratory values after receiving renal replacement therapy (RRT) among AKI patients with or without sepsis in intensive care unit (ICU). Also we examined the two different renal injury staging systems in the patients.


After obtaining approval from the Ethics Committee, patients who were admitted to ICU between 01.01.2010 - 30.06.2014 and requiring RRT in the management of AKI were enrolled. They were divided into septic shock group or nonseptic group. Glasgow coma score (GCS), vital signs, laboratory values, vasopressor or inotropic agents requirements at initiation, 12th and 24th hours of RRT were collected. APACHE II scores, 28th and 90th day mortality were also recorded. Staging of AKI was carried out based on KDIGO 2012 guidelines and RIFLE (Risk, Injury, Failure, Loss of kidney function and End-stage renal failure).


A total of 153 patients were included in the study. Ninety three patients had septic shock. APACHE II score and 28th day mortality were significantly higher in Group Septic Shock (p < 0.001,p < 0.001 respectively). In subjects above 62 years of age found associated with higher 90th day mortality (p = 0.002).

Both in two groups glomerular filtration rates, urea and creatinine levels improved after RRT initiation (p < 0.001). Also inotropic and vasopressor agent using has decreased significantly after RRT in both groups (p < 0.001).

Frequency of AKI were comparable with the KDIGO guideline and RIFLE classification (p = 0,5, p = 0,5 respectively).


Mortality rate increases when AKI complicated with sepsis and higher age. The KDIGO staging for AKI is equivalent to the RIFLE classification in septic or non-septic critically ill patients.

Authors’ Affiliations

University of Uludag, School of Medicine, Anesthesiology and ICU, Bursa, Turkey
University of Uludag, School of Medicine, Nephrology and Internal Medicine, Bursa, Turkey


  1. Lerma E, Berns JS, Nissenson A: Current Diagnosis & Treatment Nephrology & Hypertension. 1st edition. United States of America. McgrawHill Companies. 2009, 453-62.Google Scholar
  2. Bagshaw SM, et al: Septic acute kidney injury in critically ill patients:Clinical characteristics and outcomes. Clin J Am Soc Nephrol. 2007, 2: 431-9. 10.2215/CJN.03681106.PubMedView ArticleGoogle Scholar


© Kahveci et al.; 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.