Personalised glucose therapy: glucose targets in critically ill patients with pre-existing poorly controlled type 2 diabetes

In patients without pre-existing diabetes, hyperglycaemia during critical illness is associated with adverse outcomes. However, recent observational data suggest that in patients with pre-existing poorly controlled type 2 diabetes (defined as an HbA1c ≥7%) prior to their acute illness, targeting glucose concentrations < 10mmol/l is associated with harm [1]. Accordingly a higher glucose target may benefit these patients.

To determine whether more liberal glucose targets in critically ill patients with pre-existing poorly controlled type 2 diabetes increases time weighted mean glucose concentration, attenuates hypoglycaemia, and appears overtly safe.

Prospective, open-label, sequential period, pilot study of 86 patients with poorly controlled type 2 diabetes (admission HbA1c ≥ 7.0%) and a blood glucose concentration > 10mmol/L requiring admission to the Intensive Care Unit (ICU) and administration of insulin. The 'control' patients (n = 53) were consecutively admitted during a 6 month period and the 'intervention' patients (n = 33) were admitted during a subsequent 6 month period. During the 'control' period blood glucose was targeted between 6-10mmol/l, whereas during the 'intervention' period the target was 10-14mmol/l. Time weighted mean glucose was calculated and recorded blood glucose concentrations < 4.0mmol/l considered as an hypoglycaemic episode for each patient. Data are mean (SE) or median [IQR] and analysed using independent samples t-test, Mann-Whitney test, Chi-squared test, Linear and Logistic regression as appropriate.

The groups were well matched in terms of age (Control: 64.0 (2.0) vs Intervention: 62.6 (2.0) years), admission HbA1c (8.5 (0.2) vs 8.8 (0.2)%), APACHE II score (20.4 (1.0) vs 20.5 (1.2)) and Charlson Comorbidity Index (4.5 (0.3) vs 4.3 (0.3)). More liberal targets resulted in greater time weighted mean glucose concentrations (TWGlucose_day0-7 9.3 (0.3) vs 10.2 (0.4) mmol/l, P = 0.04) and there was a trend towards fewer patients with hypoglycaemic episodes (34% vs 16% of patients, P = 0.07). There was no difference in ICU mortality (10 [19%] vs 6 [18%], P = 0.94) or 90-day mortality (19 [36%] vs 12 [36%], P = 0.96). ICU length of stay was shorter in the 'control' period (3.5 [4.0] vs 6.3 [8.7] days, P = 0.01) with significance persisting when adjusting for APACHE scores and Charlson Comorbidity Index (P = 0.04).

Mean time weighted glucose between groups.

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In critically ill patients with pre-existing poorly controlled type 2 diabetes, more liberal glucose targets increase mean glucose concentrations may reduce the incidence of insulin- induced hypoglycaemia, and appear to be overtly safe. Prospective studies using larger cohorts are indicated.

Dr Kar is supported by a Royal Adelaide Hospital A.R. Clarkson Scholarship

Affiliations

1. Intensive Care Unit, Royal Adelaide Hospital, Adelaide, Australia

   • P Kar
   • , MP Plummer
   • , MJ Chapman
   •  & AM Deane

2. Discipline of Acute Care Medicine, University of Adelaide, Adelaide, Australia

   • P Kar
   • , MP Plummer
   • , MJ Chapman
   •  & AM Deane

3. Intensive Care Unit, The Austin Hospital, Melbourne, Australia

   • R Bellomo

4. NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia

   • AJ Jenkins
   •  & AS Januszewski

5. Discipline of Medicine, University of Adelaide, Adelaide, Australia

   • K Lange
   •  & M Horowitz

6. NHMRC Centre for Research Excellence, University of Adelaide, Adelaide, Australia

   • K Lange
   • , MJ Chapman
   • , M Horowitz
   •  & AM Deane

Corresponding author

Correspondence to P Kar.

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