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Volume 3 Supplement 1

ESICM LIVES 2015

  • Poster presentation
  • Open Access

Evaluation of the relation between respiratory muscle pressure (PMUS) and diaphragmatic thickness in ICU patients ventillated with proportional assist ventillation (PAV). a preliminary study

  • 1,
  • 1,
  • 1,
  • 1 and
  • 1
Intensive Care Medicine Experimental20153 (Suppl 1) :A312

https://doi.org/10.1186/2197-425X-3-S1-A312

  • Published:

Keywords

  • Respiratory Muscle
  • Interobserver Variability
  • Respiratory Parameter
  • Dynamic Feedback
  • Ultrasound Method

Introduction

Proportional Assist Ventillation (PAV) is a patient and user friendly mode of spontaneous mechanical ventilation which uses dynamic feedback of respiratory parameters to support the effort and assess the consequent workload overcomed by the patient´s respiratory muscles to which diaphragm contributes the most. The relationship of Pmus [1] (respiratory muscle pressure) and diaphragmatic function (displacement-excursion/ thickening ratio) has not however been adequately investigated.

Objectives

The aim of our study is to evaluate the relation between this Pmus (cmH2O) and the diaphragmatic function as obtained by ultrasonography in ICU patients ventillated with PAV, during weaning.

Methods

20 ICU surgical and medical patients were included in the study. All patients were off sedation able to breathe spontaneously and ventilated with PAV with a target of 6-7 ml/kg as adjusted with the gain (%support).An ultrasound study recorded the diaphragmatic displacement at the right mid axillary line and thickness at the zone of apposition [2]. The values of Ppeak, PEEP, tidal volume Vt, Sp02, compliance, % gain, displacement, Tdi (thickness at end inspiration) Tdex (thickness at end expiration) were recorded by a single operator based on the low interobserver variability [3] of the ultrasound method.

Pmus was calculated from the equation: Pmus = (Ppeak-PEEP) x ((100-gain))/gain and diaphragmatic thickening ratio from the equation: TdR = (Tdinspiration-Tdexpiration)/Tdexpiration.

Kolmogorof-Smirnof (K-S) distribution of gender, age, weight and other somatometric characteristics was normal. Data was analysed by SPSS 16.0 software using the Pearson correlation of bivariate analysis.

Results

Data results are shown:

Pearson Correlation Pmus-TR = 0.420 p = 0.065

Pearson Correlation Pmus- DISPLACEM = 0.419 p = 0.066

Conclusions

A positive but yet not statistically significant correlation is found both between the Pmus and the thickening ratio(TdR) of the diaphragm and the Pmus and the displacement of the diaphragmatic muscle. (Pearson correlation coefficient 0.420 p = 0.065 and 0.419 p = 0.066 respectively). The results so far indicate that the statistical significance should be evaluated with a larger number of patients and 2 observers in order to increase repeatability and reliability of the measurements.

Authors’ Affiliations

(1)
Nicosia General Hospital, Intensive Care Unit, Nicosia, Cyprus

References

  1. Carteaux , et al: Bedside adjustment of proportional assist ventilation to target a predefined range of respiratory effort. Crit Care Med. 2013, 41 (9): 2125-32. SepPubMedView ArticleGoogle Scholar
  2. Matamis , et al: Sonographic evaluation of the diaphragm in critically ill patients. Technique and clinical applications. Intensive Care Med. 2013, 39 (5): 801-10. MayPubMedView ArticleGoogle Scholar
  3. Goligher , et al: Measuring diaphragm thickness with ultrasound in mechanically ventilated patients: feasibility, reproducibility and validity. Intensive Care Med. 2015, Feb 19Google Scholar

Copyright

© Minas et al.; 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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