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Volume 3 Supplement 1

ESICM LIVES 2015

Prognosis of mechanically ventilated patients entering the weaning process

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Introduction

The WIND study “Weaning according to New Definition " prospectively collected epidemiologic data concerning mechanical ventilation (MV) and weaning. The aim of the present analysis was to specifically address mortality at the different pre-defined steps of the weaning process.

Methods

This is a subsequent analysis of the original prospective observational study run in 36 intensive care units in France, Spain and Switzerland over a three month period. All patients requiring intubation and MV were enrolled. MV modality, results of spontaneous breathing trials (SBT) and extubation, therapeutic limitation as well as survival were daily collected until ICU discharge or day 60. A weaning attempt (WA) was defined either by a spontaneous breathing trial or a direct extubation (planned or unplanned). Weaning success was defined as discharged alive without mechanical ventilation within the 7 days following extubation. The prognosis of patients at the key steps of the weaning process was analysed as mortality at ICU discharge or D60.

Results

2729 patients were enrolled and 20 specifically intubated for upper airway obstacle were excluded. 2709 patients were analysed among whom 2051 entered the weaning process (i.e. had at least one WA). Prognosis is reported on table 1 for the whole cohort, for the patients entering weaning, after failure of the first WA and for the patients still ventilated 7 days after the first WA.

Table 1 After failure of 1st WA, 125 patients (among the 197 dead) died in the seven first days.

Conclusions

Based on this large cohort of intubated patients, mortality was 10% for the patients entering the weaning process but was three times higher (33%) in patients failing their 1st WA; 63% of the deaths occurred within one week after the failed WA. The present analysis is the first to document mortality along different steps of the weaning process as experienced in daily practice.

Grant Acknowledgment

Association d’aide aux insuffisants respiratoires (Rouen, France)

*GB and TP are considered both as first authors.

Author information

Correspondence to G Beduneau or T Pham.

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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Cite this article

Beduneau, G., Pham, T., Richard, J. et al. Prognosis of mechanically ventilated patients entering the weaning process. ICMx 3, A426 (2015) doi:10.1186/2197-425X-3-S1-A426

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Keywords

  • Public Health
  • Intensive Care Unit
  • Observational Study
  • Mechanical Ventilation
  • Large Cohort