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- Open Access
ICP and CPP management before and after 2007: impact on the association between dose of ICP and outcome
© Boeckx et al.; 2015
- Published: 1 October 2015
- Traumatic Brain Injury
- Cerebral Perfusion Pressure
- Severe Traumatic Brain Injury
- Transition Curve
- Baseline Patient Characteristic
In a recent paper, the intracranial pressure-time burden associated with worse outcome in traumatic brain injury (TBI) patients was visualised in a color-coded plot . This color-coded plot illustrates the intuitive concept that episodes of higher intracranial pressure (ICP) can only be tolerated for shorter durations: the transition curve that delineates the duration and intensity of those ICP episodes associated with worse outcome is an approximately exponential decay curve. The study was done in a large prospective multicenter European cohort of patients, including patients from before and after 2007. In 2007, the guidelines on cerebral perfusion pressure (CPP) management in severe TBI have changed .
To assess whether CPP management before and after 2007 was different in this European multicenter cohort.
To assess whether the ability to sustain to sustain insults of elevated ICP was different in the most recent cohort.
Patients before and after 2007 were assigned to different cohorts, and standard statistical tests were used to compare the baseline patient characteristics. The mean CPP before and after 2007 was determined. The transition curve, as described in , was redrawn in the after 2007 subgroup and compared to that reported in .
In this multicenter European cohort, lower CPP levels were applied after 2007, in accordance with the BTF guidelines. When plotting the ICP time-pressure burden plot after 2007, the approximately exponential transition curve remained, albeit with shifts in the thresholds. There is not enough statistical power to assess whether the change in TBI management after 2007, has been able to influence the time and pressure thresholds at which secondary injury occurs.
Foundation for Scientific Research Flanders (FWO) (G. 0904.11). Senior clinical investigator, FWO to Geert Meyfroidt (1846113N). Methusalem program, Flemish Government to Greet Van den Berghe (METH/08/07).
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