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- Open Access
Relation of Resting Membrane Polarization and Insulin Resistance in Critically Ill Patients
© Koch et al.; 2015
- Published: 1 October 2015
- Insulin Resistance
- Conditioning Stimulus
- Motor Nerve
- Rest Membrane Potential
- Insulin Sensitivity Index
Since insulin is one agonist of the Na-K-pump, controlling resting membrane potential in muscle and nerve, we hypothesized that insulin resistance is linked to motor nerve resting membrane depolarisation in critically ill patients.
We recorded compound motor action potential from the abductor pollicis brevis muscle in ICU patients to test excitability measures of the median-nerve at baseline and during euglycemic-hyperinsulinemic clamp, proving resting membrane polarization. the recovery-of-excitability following a supra-maximal conditioning stimulus was tested at 18 conditioning test intervals, decreasing from 200 to 2 ms in geometric progression.
Insulin sensitivity index (ISI), as marker of myocellular insulin resistance, was calculated during steady state condition of euglycemic-hyperinsulinemic clamp.
Resting membrane depolarization in critically ill patients is correlated to insulin resistance. Patients with severe insulin resistance reveal a failure of repolarization, so that high dosage of insulin administration does not facilitate rectification of membrane polarization.
DFG / DGAI supported this work.
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