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- Open Access
Clinical utility of repeated blood culture sampling in critically ILL neonates
© Verstraete et al.; 2015
- Published: 1 October 2015
- Clinical Sign
- Blood Culture
- Antibiotic Therapy
- Prospective Multicenter Study
- Previous Sample
Repeated blood culture sampling is common in critically ill neonates though precise indications are unknown.
To describe clinical characteristics driving repeated blood culture sampling: clinical indications, time interval between cultures, and rates of blood culture-positivity.
Prospective multicenter study of characteristics for repeated blood culture sampling in neonates admitted to three tertiary-referral intensive care units (period 7/2013-12/2014). Repeated blood culture samples were included when obtained within 14 days after the previous sample. Clinical sepsis is defined as the presence of 2 clinical signs and the duration of antibiotic therapy for ≥5 days. Blood cultures positive for skin commensals are considered contaminated if no 2 clinical signs and no CRP of > 2mg/dL are identified.
CRP rise seems not a good indicator for repeated blood culturing, though mostly identified as an indicator in particular in the prior-ABT-cohort. Prior ABT influences indications and interval for repeated cultures but has no effect on blood culture-positivity. Repeated blood culture samples seems indicated when ≥2 clinical signs occur.
Grant by Belgian Research Fund (BOF)
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