- Poster presentation
- Open Access
TLQP-21 modulate inflammation and fibrosis in a model of ards
© Pozzi et al.; 2015
- Published: 1 October 2015
- Bronchoalveolar Lavage
- Acute Respiratory Distress Syndrome
- Collagen Deposition
- Vehicle Group
- Lung Fibrosis
TLQP-21 is a neuropeptide expressed in the brain that is involved in the control of energy homeostasis. In preliminary experiments we have observed that TLQP-21 can modulate macrophage function. In Acute Respiratory Distress Syndrome (ARDS) macrophage seems to play a critical role, contributing to lung remodeling.
To explore the therapeutic role of a short analog of TLQP-21 (JMV5656) in an experimental model of ARDS.
C57/BL6 mice received an instillation of 0.1 M HCl, 2.5 ml/kg into the right bronchus. They were treated with TLQP-21 0.6 mg/kg ip or vehicle control, 2 days before and on the same day of HCl challenge. Respiratory system compliance, blood gas analysis and differential cell counts in a selective bronchoalveolar lavage (BAL) were determined 24 h after HCl. In a parallel experiment mice were observed for 14 days to assess epithelial damage and lung fibrosis.
TLQP-21 can decrease inflammatory response at an early phase in a mouse model of HCl-induced ARDS, which may modulate lung remodeling at a late phase, preventing a fibrotic evolution. Given these encouraging but not definitive results we aim to furtherassess the potential therapeutic effect of a higher dose of TLQP-21
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.