- Poster presentation
- Open Access
Initial levels of mr-proadrenomedullin: a predictor of severity in patients with influenza a virus pneumonia
© Valenzuela Sanchez et al.; 2015
- Published: 1 October 2015
- Severe Sepsis
- Severe Pneumonia
- Sepsis Patient
High levels of MR-proadrenomedullin (MR-proADM) have been described in critical sepsis patients. This is directly related to the relaxation of vascular tone and, therefore, hypotension and the presence of organ failure in patients with septic shock. In patients with severe pneumonia due to influenza A, although without great hemodynamic compromise, the presence of respiratory failure worsens the prognosis and significantly increases mortality.
Evaluate the usefulness of MR-proADM comparing them to C-reactive protein (CRP) and procalcitonin (PCT) in the prognosis of patients with influenza A virus pneumonia.
Prospective observational multicenter study. We included patients admitted to the ICU of five hospitals in Spain with the diagnosis of severe sepsis during a period of 36 months due to influenza A virus pneumonia. Biomarker levels (MR-proADM, CRP, PCT) were determined at admission. Data were compared with a control group (CG) of patients, also with influenza virus A pneumonia, but less severe who were not admitted to the ICU.
multivariate analysis (Cox models)
Endpoint: 90-day mortality
Hazard Ratio (95%CI)
Multivariate analysis (Backward Method)
MR-proADM at admission
p = 0.0083
Initial MR-proADM levels are effective to determine the unfavorable outcome and the risk of ICU admission and mortality in patients with pneumonia due to influenza A virus.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.