- Poster presentation
- Open Access
Incidence of pathogen detection in blood cultures of severe sepsis and septic shock patients is higher, if blood cultures were drawn before anti-infective therapy
© Scheer et al.; 2015
- Published: 1 October 2015
- Public Health
- Intensive Care Unit
- High Probability
- Septic Shock
- Blood Culture
Actual guidelines for the management of severe sepsis and septic shock recommend to draw blood cultures before anti-infective therapy. The grade of recommendation for this approach is high, the evidence, however, is low (1C) . Thus, data on the influence of anti-infective therapy on microbiology results in seriously ill patients are urgently warranted.
The objective of the present study was to describe the impact of a preexisting anti-infective therapy on the incidence of pathogen detection from blood cultures in patients with severe sepsis or septic shock.
Therefore, we retrospectively analyzed the results of 4498 blood cultures (2 bottles, each with 8-10 ml, BD BACTECTM aerobic/anaerobic medium bottles per drawn) from 592 intensive care unit (medical and surgical) patients with severe sepsis or septic shock from 2010 to 2014 at the University Hospital of Greifswald, Germany. The results were rated in consideration of anti-infective therapy, time of origin of severe sepsis and septic shock and time of blood culture drawing. Values were calculated as percentage and 95%-confidence-intervals by Clopper-Pearson method.
The present results support the current recommendation to draw blood cultures before anti-infective therapy. The highest probability of positive pathogen detection is at origin of severe sepsis or septic shock. During anti-infective the detection of pathogens is significantly decreased.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.