Fig. 5
From: Heparin-binding protein is important for vascular leak in sepsis
HBP-induced signs of acute lung injury in mice in vivo. Mice were injected with intravenous heparin-binding protein (HBP) and/or unfractionated heparin (UFH) followed by continuous infusion for 1 h. Controls received vehicle (10 mM phosphate-buffered saline). The lungs were stained with hematoxylin and eosin (left) or analyzed by scanning electron microscopy (right). Hematoxylin and eosin-stained sections were scored for alveolar thickness, capillary congestion, and cellularity (see Table 2). Images from sections with a median overall score are shown. Histologic and electron microscopic images of mice treated with intraperitoneal lipopolysaccharide (LPS) from Escherichia coli 0111:B4 in a dose of 0.25 mg for 4 h are presented in lower panels