Lee WL, Slutsky AS (2010) Sepsis and endothelial permeability. N Engl J Med 363:689–691
Article
CAS
PubMed
Google Scholar
Gautam N, Olofsson AM, Herwald H, Iversen LF, Lundgren-Akerlund E, Hedqvist P, Arfors KE, Flodgaard H, Lindbom L (2001) Heparin-binding protein (HBP/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability. Nat Med 7:1123–1127
Article
CAS
PubMed
Google Scholar
Olofsson AM, Vestberg M, Herwald H, Rygaard J, David G, Arfors KE, Linde V, Flodgaard H, Dedio J, Müller-Esterl W, Lundgren-Akerlund E (1999) Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis. J Clin Invest 104:885–894
Article
CAS
PubMed
PubMed Central
Google Scholar
Soehnlein O, Xie X, Ulbrich H, Kenne E, Rotzius P, Flodgaard H, Eriksson EE, Lindbom L (2005) Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions. J Immunol 174:6399–6405
Article
CAS
PubMed
Google Scholar
Linder A, Christensson B, Herwald H, Björck L, Åkesson P (2009) Heparin-binding protein: an early marker of circulatory failure in sepsis. Clin Infect Dis 49:1044–1050
Article
CAS
PubMed
Google Scholar
Linder A, Åkesson P, Inghammar M, Treutiger CJ, Linner A, Sunden-Cullberg J (2012) Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock. Crit Care 16:R90
Article
PubMed
PubMed Central
Google Scholar
Linder A, Arnold R, Boyd JH, Zindovic M, Zindovic I, Lange A, Paulsson M, Nyberg P, Russell JA, Pritchard D, Christensson B, Åkesson P (2015) Heparin-binding protein improves prediction of severe infections with organ dysfunction in the emergency department. Crit Care Med 43:2378–2386
Article
CAS
PubMed
PubMed Central
Google Scholar
Lin Q, Shen J, Shen L, Zhang Z, Fu F (2013) Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome. Crit Care 17:R155
Article
PubMed
PubMed Central
Google Scholar
Russell JA, Walley KR, Singer J, Gordon AC, Hébert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D, Investigators VASST (2008) Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 358:877–887
Article
CAS
PubMed
Google Scholar
Bouchard J, Soroko SB, Chertow GM, Himmelfarb J, Ikizler TA, Paganini EP, Mehta RL (2009) Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int 76:422–427
Article
PubMed
Google Scholar
Stein A, de Souza LV, Belettini CR, Menegazzo WR, Viégas JR, Costa Pereira EM, Eick R, Araújo L, Consolim-Colombo F, Irigoyen MC (2012) Fluid overload and changes in serum creatinine after cardiac surgery: predictors of mortality and longer intensive care stay. A prospective cohort study. Crit Care 16:R99
Article
PubMed
PubMed Central
Google Scholar
Kazakoff PW, McGuire TR, Hoie EB, Cano M, Iversen PL (1995) An in vitro model for endothelial permeability: assessment of monolayer integrity. In Vitro Cell Dev Biol Anim 31:846–852
Article
CAS
PubMed
Google Scholar
Dull RO, Dinavahi R, Schwartz L, Humphries DE, Berry D, Sasisekharan R, Garcia JG (2003) Lung endothelial heparan sulfates mediate cationic peptide-induced barrier dysfunction: a new role for the glycocalyx. Am J Physiol Lung Cell Mol Physiol 285:L986–L995
Article
CAS
PubMed
Google Scholar
Clements RT, Minnear FL, Singer HA, Keller RS, Vincent PA (2005) RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability. Am J Physiol Lung Cell Mol Physiol 288:L294–L306
Article
CAS
PubMed
Google Scholar
Griffith GL, Russell RA, Kasus-Jacobi A, Thavathiru E, Gonzalez ML, Logan S, Pereira HA (2013) CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. Invest Ophthalmol Vis Sci 54:6712–6723
Article
CAS
PubMed
PubMed Central
Google Scholar
Hirsh J, Anand SS, Halperin JL, Fuster V (2001) Guide to anticoagulant therapy: heparin: a statement for healthcare professionals from the American Heart Association. Circulation 103:2994–3018
Article
CAS
PubMed
Google Scholar
Bates SM, Weitz JI (2005) Coagulation assays. Circulation 112:e53–e60
Article
PubMed
Google Scholar
Ding R, Zhao D, Guo R, Zhang Z, Ma X (2011) Treatment with unfractionated heparin attenuates coagulation and inflammation in endotoxemic mice. Thromb Res 128:e160–e165
Article
CAS
PubMed
Google Scholar
Kozar RA, Peng Z, Zhang R, Holcomb JB, Pati S, Park P, Ko TC, Paredes A (2011) Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock. Anesth Analg 112:1289–1295
Article
PubMed
PubMed Central
Google Scholar
Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S (2013) Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-α antibodies. PLoS ONE 12:e79037
Article
Google Scholar
Linder A, Soehnlein O, Akesson P (2010) Roles of heparin-binding protein in bacterial infections. J Innate Immun 2(5):431–438
Article
CAS
PubMed
Google Scholar
Chappell D, Jacob M, Rehm M, Stoeckelhuber M, Welsch U, Conzen P, Becker BF (2008) Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx. Biol Chem 389:79–82
Article
CAS
PubMed
Google Scholar
Hamai A, Hashimoto N, Mochizuki H, Kato F, Makiguchi Y, Horie K, Suzuki S (1997) Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides. J Biol Chem 272:9123–9130
Article
CAS
PubMed
Google Scholar
Yamagata T, Saito H, Habuchi O, Suzuki S (1968) Purification and properties of bacterial chondroitinases and chondrosulfatases. J Biol Chem 243:1523–1535
CAS
PubMed
Google Scholar
Siflinger-Birnboim A, Johnson A (2003) Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury. Am J Physiol Lung Cell Mol Physiol 284:L435–L451
Article
CAS
PubMed
Google Scholar
Pereira HA, Moore P, Grammas P (1996) CAP37, a neutrophil granule-derived protein stimulates protein kinase C activity in endothelial cells. J Leukoc Biol 60:415–422
CAS
PubMed
Google Scholar
Mehta D, Rahman A, Malik AB (2001) Protein kinase C-α signals Rho-guanine nucleotide dissociation inhibitor phosphorylation and Rho activation and regulates the endothelial cell barrier function. J Biol Chem 276:22614–22620
Article
CAS
PubMed
Google Scholar
Iversen LF, Kastrup JS, Bjørn SE, Rasmussen PB, Wiberg FC, Flodgaard HJ, Larsen IK (1997) Structure of HBP, a multifunctional protein with a serine proteinase fold. Nat Struct Biol 4:265–268
Article
CAS
PubMed
Google Scholar
Johansson J, Brattström O, Sjöberg F, Lindbom L, Herwald H, Weitzberg E, Oldner A (2013) Heparin-binding protein (HBP): an early marker of respiratory failure after trauma? Acta Anaesthesiol Scand 57:580–586
Article
CAS
PubMed
Google Scholar
Kaukonen KM, Linko R, Herwald H, Lindbom L, Ruokonen E, Ala-Kokko T, Pettilä V (2013) Heparin-binding protein (HBP) in critically ill patients with influenza A(H1N1) infection. Clin Microbiol Infect 19:1122–1128. doi:10.1111/1469-0691.12156
Article
CAS
PubMed
Google Scholar
Tydén J, Herwald H, Sjöberg F, Johansson J (2016) Increased plasma levels of heparin-binding protein on admission to intensive care are associated with respiratory and circulatory failure. PLoS ONE 11(3):e0152035
Article
PubMed
PubMed Central
Google Scholar
Filmus J, Capurro M, Rast J (2008) Glypicans. Genome Biol 9:224
Article
PubMed
PubMed Central
Google Scholar
Saunders S, Paine-Saunders S, Lander AD (1997) Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol 190:78–93
Article
CAS
PubMed
Google Scholar
Tkachenko E, Rhodes JM, Simons M (2005) Syndecans: new kids on the signaling block. Circ Res 96:488–500
Article
CAS
PubMed
Google Scholar
Vuong TT, Reine TM, Sudworth A, Jenssen TG, Kolset SO (2015) Syndecan-4 is a major syndecan in primary human endothelial cells in vitro, modulated by inflammatory stimuli and involved in wound healing. Histochem Cytochem 63:280–292
Article
CAS
Google Scholar
Deepa SS, Yamada S, Zako M, Goldberger O, Sugahara K (2004) Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor. J Biol Chem 279:37368–37376
Article
CAS
PubMed
Google Scholar
Oh ES, Woods A, Couchman JR (1997) Syndecan-4 proteoglycan regulates the distribution and activity of protein kinase C. J Biol Chem 272:8133–8136
Article
CAS
PubMed
Google Scholar
Saoncella S, Echtermeyer F, Denhez F, Nowlen JK, Mosher DF, Robinson SD, Hynes RO, Goetinck PF (1999) Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers. Proc Natl Acad Sci U S A 96:2805–2810
Article
CAS
PubMed
PubMed Central
Google Scholar
Jaimes F, De La Rosa G, Morales C, Fortich F, Arango C, Aguirre D, Muñoz A (2009) Unfractioned heparin for treatment of sepsis: a randomized clinical trial (The HETRASE Study). Crit Care Med 37:1185–1196
Article
CAS
PubMed
Google Scholar
Wang C, Chi C, Guo L, Wang X, Guo L, Sun J, Sun B, Liu S, Chang X, Li E (2014) Heparin therapy reduces 28-day mortality in adult severe sepsis patients: a systematic review and meta-analysis. Crit Care 18:563
Article
PubMed
PubMed Central
Google Scholar
Zarychanski R, Abou-Setta AM, Kanji S, Turgeon AF, Kumar A, Houston DS, Rimmer E, Houston BL, McIntyre L, Fox-Robichaud AE, Hébert P, Cook DJ, Fergusson DA, Canadian Critical Care Trials Group (2015) The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis. Crit Care Med 43:511–518
Article
CAS
PubMed
Google Scholar
Zarychanski R, Doucette S, Fergusson D, Roberts D, Houston DS, Sharma S, Gulati H, Kumar A (2008) Early intravenous unfractionated heparin and mortality in septic shock. Crit Care Med 36:2973–2979
Article
CAS
PubMed
Google Scholar
Hofstra J, Vlaar A, Prins D, Koh G, Levi M, Schultz M, Binnekade J, Juffermans N (2012) Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome—a retrospective propensity matched cohort study. BMC Pulm Med 12:43
Article
CAS
PubMed
PubMed Central
Google Scholar