Skip to main content

Table 2 Plasma concentrations of cytokines and endothelial cell activation markers treated with the B1R antagonist R-715 or the B2R antagonist HOE-140

From: Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis

(pg/ml)

Vehicle

R-715

HOE-140

IFN-γ

5 (2–8)

7 (2–17)

4 (2–9)

IL-6

138 (66–374)

209 (53–626)

174 (77–272)

IL-10

3 (2–5)

4 (2–6)

2 (1–5)

TNF-α

64 (19–172)

110 (23–207)

97 (34–138)

Soluble E-selectin (ng/ml)

30 (23–37)

47 (37–55)**

40 (30–49)

Soluble VCAM-1 (ng/ml)

2202 (1358–2616)

2497 (1899–3554)

2365 (2096–2843)

  1. Data are medians with interquartile ranges of eight mice per group at 40 h after infection. **P < 0.005 vs vehicle control