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Table 2 Plasma concentrations of cytokines and endothelial cell activation markers treated with the B1R antagonist R-715 or the B2R antagonist HOE-140

From: Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis

(pg/ml) Vehicle R-715 HOE-140
IFN-γ 5 (2–8) 7 (2–17) 4 (2–9)
IL-6 138 (66–374) 209 (53–626) 174 (77–272)
IL-10 3 (2–5) 4 (2–6) 2 (1–5)
TNF-α 64 (19–172) 110 (23–207) 97 (34–138)
Soluble E-selectin (ng/ml) 30 (23–37) 47 (37–55)** 40 (30–49)
Soluble VCAM-1 (ng/ml) 2202 (1358–2616) 2497 (1899–3554) 2365 (2096–2843)
  1. Data are medians with interquartile ranges of eight mice per group at 40 h after infection. **P < 0.005 vs vehicle control