Fig. 3
From: Bench to bedside review: therapeutic modulation of nitric oxide in sepsis—an update
Arginine bioavailability. Arginine (ARG) is transported into the cell via cationic amino acid transporters and is converted to citrulline (Cit) and NO. Citrulline derived from a number of sources including diet can be converted to arginine by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) increasing the available intracellular arginine. Arginase (ARG) metabolises arginine to ornithine (Orn) and urea (Ur)