Day 1 | Day 3 | Day 7 | |||||||
---|---|---|---|---|---|---|---|---|---|
Variable | Intervention | Control | p | Intervention | Control | p | Intervention | Control | p |
Tidal volume, mL/kg of predicted body weight | 6.1 (0.3) [n = 1762] | 6.2 (0.3) [n = 1778] | 0.07 | 6.3 (0.4) [n = 1475] | 6.3 (0.3) [n = 1553] | 0.62 | 6.6 (0.4) [n = 926] | 6.5 (0.3) [n = 1028] | 0.93 |
Set PEEP, cmH2O | 14.8 (1.2) [n = 1813] | 10.1 (2.1) [n = 1839] | < 0.001 | 13.2 (1.4) [n = 1627] | 9.4 (1.8) [n = 1663] | < 0.001 | 10.4 (1.4) [n = 1142] | 8.6 (1.7) [n = 1213] | < 0.001 |
Driving pressure, cmH2O | 12.6 (1.1) [n = 1793] | 14.0 (0.9) [n = 1826] | < 0.001 | 12.7 (2.2) [n = 1599] | 14.1 (1.3) [n = 1640] | 0.013 | 13.8 (2.8) [n = 1114] | 14.7 (1.8) [n = 1193] | 0.26 |
Plateau pressure, cmH2O | 27.6 (1.1) [n = 1740] | 24.4 (1.9) [n = 1715] | <0.001 | 26.1 (1.6) [n = 1445] | 23.7 (1.8) [n = 1511] | 0.001 | 24.4 (2.5) [n = 873] | 23.6 (1.9) [n = 965] | 0.176 |
Respiratory rate, min-1 | 27.4 (2.2) [n = 1800] | 27.3 (1.7) [n = 1841] | 0.57 | 26.4 (2.2) [n = 1606] | 27.3 (1.3) [n = 1680] | 0.50 | 26.0 (1.7) [n = 1136] | 26.3 (0.8) [n = 1193] | > 0.99 |
FIO2 | 0.50 (0.05) [n = 1180] | 0.59 (0.05) [n = 1193] | < 0.001 | 0.45 (0.04) [n = 1065] | 0.53 (0.04) [n = 1088] | < 0.001 | 0.44 (0.05) [n = 739] | 0.50 (0.04) [n = 785] | 0.023 |
PaO2/FIO2, mmHg | 208.3 (16.6) [n = 1719] | 152.6 (10.9) [n = 1649] | < 0.001 | 224.1 (24.0) [n = 1537] | 168.0 (12.5) [n = 1575] | < 0.001 | 216.1 (23.5) [n = 1101] | 185.0 (17.1) [n = 1179] | < 0.001 |
PaO2, mmHg | 95.1 (9.6) [n = 1180] | 82.1 (3.9) [n = 1200] | < 0.001 | 91.3 (12.0) [n = 1066] | 87.4 (10.2) [n = 1089] | 0.54 | 81.8 (7.0) [n = 726] | 82.0 (6.0) [n = 769] | 0.80 |
PaCO2, mmHg | 47.1 (4.9) [n = 1785] | 45.6 (3.5) [n = 1809] | 0.07 | 45.3 (3.6) [n = 1574] | 46.0 (3.2) [n = 1611] | 0.37 | 44.6 (3.2) [n = 1168] | 46.1 (3.1) [n = 1244] | 0.013 |
pHa | 7.34 (0.04) [n = 1785] | 7.35 (0.03) [n = 1809] | 0.033 | 7.38 (0.02) [n = 1575] | 7.38 (0.03) [n = 1612] | 0.99 | 7.40 (0.01) [n = 1168] | 7.40 (0.02) [n = 1244] | 0.53 |