Skip to main content

Table 3 Ventilator and blood gas analysis parameters collected at day 1, 3 and 7

From: Effects of higher PEEP and recruitment manoeuvres on mortality in patients with ARDS: a systematic review, meta-analysis, meta-regression and trial sequential analysis of randomized controlled trials

  Day 1 Day 3 Day 7
Variable Intervention Control p Intervention Control p Intervention Control p
Tidal volume, mL/kg of predicted body weight 6.1 (0.3) [n = 1762] 6.2 (0.3) [n = 1778] 0.07 6.3 (0.4) [n = 1475] 6.3 (0.3) [n = 1553] 0.62 6.6 (0.4) [n = 926] 6.5 (0.3) [n = 1028] 0.93
Set PEEP, cmH2O 14.8 (1.2) [n = 1813] 10.1 (2.1) [n = 1839] < 0.001 13.2 (1.4) [n = 1627] 9.4 (1.8) [n = 1663] < 0.001 10.4 (1.4) [n = 1142] 8.6 (1.7) [n = 1213] < 0.001
Driving pressure, cmH2O 12.6 (1.1) [n = 1793] 14.0 (0.9) [n = 1826] < 0.001 12.7 (2.2) [n = 1599] 14.1 (1.3) [n = 1640] 0.013 13.8 (2.8) [n = 1114] 14.7 (1.8) [n = 1193] 0.26
Plateau pressure, cmH2O 27.6 (1.1) [n = 1740] 24.4 (1.9) [n = 1715] <0.001 26.1 (1.6) [n = 1445] 23.7 (1.8) [n = 1511] 0.001 24.4 (2.5) [n = 873] 23.6 (1.9) [n = 965] 0.176
Respiratory rate, min-1 27.4 (2.2) [n = 1800] 27.3 (1.7) [n = 1841] 0.57 26.4 (2.2) [n = 1606] 27.3 (1.3) [n = 1680] 0.50 26.0 (1.7) [n = 1136] 26.3 (0.8) [n = 1193] > 0.99
FIO2 0.50 (0.05) [n = 1180] 0.59 (0.05) [n = 1193] < 0.001 0.45 (0.04) [n = 1065] 0.53 (0.04) [n = 1088] < 0.001 0.44 (0.05) [n = 739] 0.50 (0.04) [n = 785] 0.023
PaO2/FIO2, mmHg 208.3 (16.6) [n = 1719] 152.6 (10.9) [n = 1649] < 0.001 224.1 (24.0) [n = 1537] 168.0 (12.5) [n = 1575] < 0.001 216.1 (23.5) [n = 1101] 185.0 (17.1) [n = 1179] < 0.001
PaO2, mmHg 95.1 (9.6) [n = 1180] 82.1 (3.9) [n = 1200] < 0.001 91.3 (12.0) [n = 1066] 87.4 (10.2) [n = 1089] 0.54 81.8 (7.0) [n = 726] 82.0 (6.0) [n = 769] 0.80
PaCO2, mmHg 47.1 (4.9) [n = 1785] 45.6 (3.5) [n = 1809] 0.07 45.3 (3.6) [n = 1574] 46.0 (3.2) [n = 1611] 0.37 44.6 (3.2) [n = 1168] 46.1 (3.1) [n = 1244] 0.013
pHa 7.34 (0.04) [n = 1785] 7.35 (0.03) [n = 1809] 0.033 7.38 (0.02) [n = 1575] 7.38 (0.03) [n = 1612] 0.99 7.40 (0.01) [n = 1168] 7.40 (0.02) [n = 1244] 0.53
  1. Values are estimated means (standard deviations) calculated with a mixed-effects model using the DerSimonian-Laird method. Number of patients at each time-point is also reported, as in some study or time point values were missing or not reported as means (standard deviations). PEEP positive end-expiratory pressure