Effects of higher PEEP and recruitment manoeuvres on mortality in patients with ARDS: a systematic review, meta-analysis, meta-regression and trial sequential analysis of randomized controlled trials

Ball, Lorenzo; Serpa Neto, Ary; Trifiletti, Valeria; Mandelli, Maura; Firpo, Iacopo; Robba, Chiara; Gama de Abreu, Marcelo; Schultz, Marcus J.; Patroniti, Nicolò; Rocco, Patricia R. M.; Pelosi, Paolo

doi:10.1186/s40635-020-00322-2

Intensive Care Medicine Experimental

Table 3 Ventilator and blood gas analysis parameters collected at day 1, 3 and 7

From: Effects of higher PEEP and recruitment manoeuvres on mortality in patients with ARDS: a systematic review, meta-analysis, meta-regression and trial sequential analysis of randomized controlled trials

	Day 1			Day 3			Day 7
Variable	Intervention	Control	p	Intervention	Control	p	Intervention	Control	p
Tidal volume, mL/kg of predicted body weight	6.1 (0.3) [n = 1762]	6.2 (0.3) [n = 1778]	0.07	6.3 (0.4) [n = 1475]	6.3 (0.3) [n = 1553]	0.62	6.6 (0.4) [n = 926]	6.5 (0.3) [n = 1028]	0.93
Set PEEP, cmH₂O	14.8 (1.2) [n = 1813]	10.1 (2.1) [n = 1839]	< 0.001	13.2 (1.4) [n = 1627]	9.4 (1.8) [n = 1663]	< 0.001	10.4 (1.4) [n = 1142]	8.6 (1.7) [n = 1213]	< 0.001
Driving pressure, cmH₂O	12.6 (1.1) [n = 1793]	14.0 (0.9) [n = 1826]	< 0.001	12.7 (2.2) [n = 1599]	14.1 (1.3) [n = 1640]	0.013	13.8 (2.8) [n = 1114]	14.7 (1.8) [n = 1193]	0.26
Plateau pressure, cmH₂O	27.6 (1.1) [n = 1740]	24.4 (1.9) [n = 1715]	<0.001	26.1 (1.6) [n = 1445]	23.7 (1.8) [n = 1511]	0.001	24.4 (2.5) [n = 873]	23.6 (1.9) [n = 965]	0.176
Respiratory rate, min^-1	27.4 (2.2) [n = 1800]	27.3 (1.7) [n = 1841]	0.57	26.4 (2.2) [n = 1606]	27.3 (1.3) [n = 1680]	0.50	26.0 (1.7) [n = 1136]	26.3 (0.8) [n = 1193]	> 0.99
FIO₂	0.50 (0.05) [n = 1180]	0.59 (0.05) [n = 1193]	< 0.001	0.45 (0.04) [n = 1065]	0.53 (0.04) [n = 1088]	< 0.001	0.44 (0.05) [n = 739]	0.50 (0.04) [n = 785]	0.023
PaO₂/FIO₂, mmHg	208.3 (16.6) [n = 1719]	152.6 (10.9) [n = 1649]	< 0.001	224.1 (24.0) [n = 1537]	168.0 (12.5) [n = 1575]	< 0.001	216.1 (23.5) [n = 1101]	185.0 (17.1) [n = 1179]	< 0.001
PaO₂, mmHg	95.1 (9.6) [n = 1180]	82.1 (3.9) [n = 1200]	< 0.001	91.3 (12.0) [n = 1066]	87.4 (10.2) [n = 1089]	0.54	81.8 (7.0) [n = 726]	82.0 (6.0) [n = 769]	0.80
PaCO₂, mmHg	47.1 (4.9) [n = 1785]	45.6 (3.5) [n = 1809]	0.07	45.3 (3.6) [n = 1574]	46.0 (3.2) [n = 1611]	0.37	44.6 (3.2) [n = 1168]	46.1 (3.1) [n = 1244]	0.013
pHa	7.34 (0.04) [n = 1785]	7.35 (0.03) [n = 1809]	0.033	7.38 (0.02) [n = 1575]	7.38 (0.03) [n = 1612]	0.99	7.40 (0.01) [n = 1168]	7.40 (0.02) [n = 1244]	0.53

Values are estimated means (standard deviations) calculated with a mixed-effects model using the DerSimonian-Laird method. Number of patients at each time-point is also reported, as in some study or time point values were missing or not reported as means (standard deviations). PEEP positive end-expiratory pressure

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