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Table 1 Comparison between stages 5 (S5), 6 (S6) and 7 (S7), that is, unilateral lung ventilation without gas flow (Stages 5 and 7) and with gas flow (Stage 6)

From: Lung perfusion during veno-venous extracorporeal membrane oxygenation in a model of hypoxemic respiratory failure

  S5: Unilateral ventilation
ECMO + Gas Flow OFF
S6: Unilateral ventilation
ECMO + Gas Flow ON
S7: Unilateral ventilation
ECMO + Gas OFF
P value
Respiratory variables
Respiratory Rate (ipm) 35 [35, 35] 35 [35, 35] 35 [35, 35] 0.409
Tidal volume (ml) 160 [152, 175] 150 [149, 155] 170 [164, 200] 0.456
Plato pressure (cmH2O) 24 [19, 31] 23 [22, 26] 32 [25, 34] 0.045
FiO2 (%) 30 [25, 35] 35 [30, 50] 35 [35, 60] 0.378
PEEP (cmH2O) 5 [5] 5 [5] 5 [5] 1.000
PaO2 (mmHg) 61,8 [56.7, 68.0] 77.3 [68, 95] 56.1 [53.7, 59.2] 0.011
PaCO2 (mmHg) 43.3 [38.5, 47.1] 42.7 [39.7, 45.3} 45.2 [39.5, 48,0] 0.240
SaO2 (%) 85.7 [84.9, 88.8] 92.4 [91.8, 94.5] 80.2 [76.0, 87.1] 0.004
PvO2 (mmHg) 29 [25.3, 30.4] 56.1 [51.5, 63.7] 27.4 [25.8, 29.7] 0.002
SvO2 (%) 45 [43,46] 84 [83,88] 42 [40,58] 0.004
Hemodynamic variables
Heart rate (bpm) 122 [114, 134] 117 [95, 120] 136 [123, 142] 0.122
MAP (mmHg) 105 [101, 109] 103 [86, 109] 104 [83, 112] 0.437
MPAP (mmHg) 37 [33,37] 23 [22,27] 39 [37,43] 0.010
CVP (mmHg) 13 [9, 13] 11 [11, 15] 10 [7, 13] 0.525
Wedge pressure (mmHg) 13 [12, 13] 9 [8, 10] 10 [9, 13] 0.019
Cardiac output (l/min) 4.6 [4.3, 5.7] 4.3 [3.5, 6.8] 3.9 [3.8, 5.7] 0.160
Metabolic variables     
Temperature (oC) 38 [37.2, 38.2] 37.9 [36.8, 38.4] 38 [37.2, 38.4] 0.254
pHa 7.39 [7.17, 7.39] 7.40 [7.39, 7.40] 7.35 [7.27, 7.37] 0.347
BE − 0.2 [− 10.4, 1.3] 0.1 9–3.6, 1.2] − 1.9 [− 9.5, 1.5] 0.697
Lactate (mg/dl) 8 [5, 14] 6 [5, 10] 9 [5, 10] 0.564
Hemoglobin (g/dl) 8.9 [8.7, 9.7] 8.4 [8.2, 8.5] 9.5 [7.6, 10.2] 0.412
  1. SvO2 denotes venous oxygen saturation acquired in the Pulmonary Arterial Catheter; PaO2 and PvO2 denotes arterial and venous oxygen partial pressure, respectively; PaCO2 denotes arterial carbon dioxide partial pressure; SaO2 denotes arterial oxygen saturation; MAP denotes mean arterial pressure; MPAP denotes mean pulmonary arterial pressure; CVP denotes central venous pressure; and BE denotes Base Excess