Table 1 Comparison between stages 5 (S5), 6 (S6) and 7 (S7), that is, unilateral lung ventilation without gas flow (Stages 5 and 7) and with gas flow (Stage 6)
S5: Unilateral ventilation ECMO + Gas Flow OFF | S6: Unilateral ventilation ECMO + Gas Flow ON | S7: Unilateral ventilation ECMO + Gas OFF | P value | |
|---|---|---|---|---|
Respiratory variables | ||||
Respiratory Rate (ipm) | 35 [35, 35] | 35 [35, 35] | 35 [35, 35] | 0.409 |
Tidal volume (ml) | 160 [152, 175] | 150 [149, 155] | 170 [164, 200] | 0.456 |
Plato pressure (cmH2O) | 24 [19, 31] | 23 [22, 26] | 32 [25, 34] | 0.045 |
FiO2 (%) | 30 [25, 35] | 35 [30, 50] | 35 [35, 60] | 0.378 |
PEEP (cmH2O) | 5 [5] | 5 [5] | 5 [5] | 1.000 |
PaO2 (mmHg) | 61,8 [56.7, 68.0] | 77.3 [68, 95] | 56.1 [53.7, 59.2] | 0.011 |
PaCO2 (mmHg) | 43.3 [38.5, 47.1] | 42.7 [39.7, 45.3} | 45.2 [39.5, 48,0] | 0.240 |
SaO2 (%) | 85.7 [84.9, 88.8] | 92.4 [91.8, 94.5] | 80.2 [76.0, 87.1] | 0.004 |
PvO2 (mmHg) | 29 [25.3, 30.4] | 56.1 [51.5, 63.7] | 27.4 [25.8, 29.7] | 0.002 |
SvO2 (%) | 45 [43,46] | 84 [83,88] | 42 [40,58] | 0.004 |
Hemodynamic variables | ||||
Heart rate (bpm) | 122 [114, 134] | 117 [95, 120] | 136 [123, 142] | 0.122 |
MAP (mmHg) | 105 [101, 109] | 103 [86, 109] | 104 [83, 112] | 0.437 |
MPAP (mmHg) | 37 [33,37] | 23 [22,27] | 39 [37,43] | 0.010 |
CVP (mmHg) | 13 [9, 13] | 11 [11, 15] | 10 [7, 13] | 0.525 |
Wedge pressure (mmHg) | 13 [12, 13] | 9 [8, 10] | 10 [9, 13] | 0.019 |
Cardiac output (l/min) | 4.6 [4.3, 5.7] | 4.3 [3.5, 6.8] | 3.9 [3.8, 5.7] | 0.160 |
Metabolic variables | ||||
Temperature (oC) | 38 [37.2, 38.2] | 37.9 [36.8, 38.4] | 38 [37.2, 38.4] | 0.254 |
pHa | 7.39 [7.17, 7.39] | 7.40 [7.39, 7.40] | 7.35 [7.27, 7.37] | 0.347 |
BE | − 0.2 [− 10.4, 1.3] | 0.1 9–3.6, 1.2] | − 1.9 [− 9.5, 1.5] | 0.697 |
Lactate (mg/dl) | 8 [5, 14] | 6 [5, 10] | 9 [5, 10] | 0.564 |
Hemoglobin (g/dl) | 8.9 [8.7, 9.7] | 8.4 [8.2, 8.5] | 9.5 [7.6, 10.2] | 0.412 |