Skip to main content

Articles

Page 2 of 29

  1. Mechanical ventilation [MV] is a life-saving technique delivered to critically ill patients incapable of adequately ventilating and/or oxygenating due to respiratory or other disease processes. This necessaril...

    Authors: Oscar Peñuelas, Elena Keough, Lucía López-Rodríguez, Demetrio Carriedo, Gesly Gonçalves, Esther Barreiro and José Ángel Lorente

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):48

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  2. Anemia of inflammation (AI) is common in critically ill patients. Although this syndrome negatively impacts the outcome of critical illness, understanding of its pathophysiology is limited. Also, new therapies...

    Authors: Margit Boshuizen, Robin van Bruggen, Sebastian A. Zaat, Marcus J. Schultz, Eli Aguilera, Ana Motos, Tarek Senussi, Francesco Antonio Idone, Paolo Pelosi, Antonio Torres, Gianluigi Li Bassi and Nicole P. Juffermans

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):47

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  3. Extracorporeal life support (ECLS) encompasses a wide range of extracorporeal modalities that offer short- and intermediate-term mechanical support to the failing heart or lung. Apart from the daily use of car...

    Authors: Abdulrahman Al-Fares, Tommaso Pettenuzzo and Lorenzo Del Sorbo

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):46

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  4. Sepsis is a highly lethal disorder. Organ dysfunction in sepsis is not defined as a clinicopathological entity but rather by changes in clinical, physiological, or biochemical parameters. Pathogenesis and spec...

    Authors: Antonio M. Garofalo, Marta Lorente-Ros, Gesly Goncalvez, Demetrio Carriedo, Aída Ballén-Barragán, Ana Villar-Fernández, Óscar Peñuelas, Raquel Herrero, Rosario Granados-Carreño and José A. Lorente

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):45

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  5. Semi-quantification of lung aeration by ultrasound helps to assess presence and extent of pulmonary pathologies, including the acute respiratory distress syndrome (ARDS). It is uncertain which lung regions add...

    Authors: Luigi Pisani, Veronica Vercesi, Patricia S. I. van Tongeren, Wim K. Lagrand, Stije J. Leopold, Mischa A. M. Huson, Patricia C. Henwood, Andrew Walden, Marry R. Smit, Elisabeth D. Riviello, Paolo Pelosi, Arjen M. Dondorp and Marcus J. Schultz

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):44

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  6. Mechanical ventilation is common in critically ill patients. This life-saving treatment can cause complications and is also associated with long-term sequelae. Patient-ventilator asynchronies are frequent but ...

    Authors: Candelaria de Haro, Ana Ochagavia, Josefina López-Aguilar, Sol Fernandez-Gonzalo, Guillem Navarra-Ventura, Rudys Magrans, Jaume Montanyà and Lluís Blanch

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):43

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  7. Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standa...

    Authors: Derek J. B. Kleinveld, Mathijs R. Wirtz, Daan P. van den Brink, M. Adrie W. Maas, Joris J. T. H. Roelofs, J. Carel Goslings, Markus W. Hollmann and Nicole P. Juffermans

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):42

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  8. Mesenchymal stem/stromal cells (MSCs) are undergoing intensive translational research for several debilitating conditions, including critical illnesses such as ARDS and sepsis. MSCs exert diverse biologic effe...

    Authors: Claire H. Masterson, Gerard F. Curley and John G. Laffey

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):41

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  9. Current treatment of acute respiratory distress syndrome (ARDS) in critically ill patients is limited to supportive measures including mechanical ventilation. It is our view that effective therapies for ARDS c...

    Authors: Nicole P. Juffermans, Marcus Schultz, Lieuwe D. Bos, Oscar Penuelas, John Laffey and Jose A. Lorente

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):40

    Content type: Meeting report

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  10. The biological effects and physiological consequences of hypercapnia are increasingly understood. The literature on hypercapnia is confusing, and at times contradictory. On the one hand, it may have protective...

    Authors: Luis Morales-Quinteros, Marta Camprubí-Rimblas, Josep Bringué, Lieuwe D. Bos, Marcus J. Schultz and Antonio Artigas

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):39

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  11. To describe the possible modes of action of probiotics and provide a systematic review of the current evidence on the efficacy of probiotics to prevent ventilator-associated pneumonia (VAP) in critically ill p...

    Authors: Marel C. E. van Ruissen, Lieuwe D. Bos, Robert P. Dickson, Arjen M. Dondorp, Constance Schultsz and Marcus J. Schultz

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):37

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  12. In acute respiratory distress syndrome (ARDS), uncontrolled production of activators of coagulation and proinflammatory mediators results in a shift from an adequate local innate immune response to hypercoagul...

    Authors: Jenny Juschten, Sarah Anne Ingelse, Martinus Adrianus Wilhelmus Maas, Armand Roelof Johan Girbes, Nicole Petra Juffermans, Marcus Josephus Schultz and Pieter Roel Tuinman

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):36

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  13. The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS). The current study explored the association between pulmonary depositions...

    Authors: Friso M. de Beer, Mark P. V. Begieneman, Joris J. T. H. Roelofs, Janneke Horn, Hans W. M. Niessen, Marcus J. Schultz and Wim K. Lagrand

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):35

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  14. Mechanical ventilation is a life-saving therapy in patients with acute respiratory distress syndrome (ARDS). However, mechanical ventilation itself causes severe co-morbidities in that it can trigger ventilato...

    Authors: Jana Grune, Arata Tabuchi and Wolfgang M. Kuebler

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):34

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  15. Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death. The aim of this study wa...

    Authors: Avi Gillis, Michael Beil, Karin Halevi-Tobias, Peter Vernon van Heerden, Sigal Sviri and Zvia Agur

    Citation: Intensive Care Medicine Experimental 2019 7:32

    Content type: Research

    Published on:

  16. Sepsis-induced immunosuppression is a key factor contributing to the morbidity and mortality of critically ill patients, and polymorphonuclear neutrophil dysfunction is believed to be a hallmark of this immuno...

    Authors: Lauren Miller, Kai Singbartl, Zissis C. Chroneos, Victor Ruiz-Velasco, Charles H. Lang and Anthony Bonavia

    Citation: Intensive Care Medicine Experimental 2019 7:30

    Content type: Research

    Published on:

  17. Circulating cell-free DNA (cfDNA) may contribute to the pathophysiology of post-injury inflammation and coagulation in trauma. However, the source and mechanism of release of cfDNA in trauma is not well unders...

    Authors: Nicholas L. Jackson Chornenki, Robert Coke, Andrew C. Kwong, Dhruva J. Dwivedi, Michael K. Xu, Ellen McDonald, John C. Marshall, Alison E. Fox-Robichaud, Emmanuel Charbonney and Patricia C. Liaw

    Citation: Intensive Care Medicine Experimental 2019 7:29

    Content type: Research

    Published on:

  18. Septic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation—as an early marker of immune suppression, or as a consequence of the later—is not known precisely...

    Authors: François Mallet, Magali Perret, Trang Tran, Boris Meunier, Audrey Guichard, Olivier Tabone, Marine Mommert, Karen Brengel-Pesce, Fabienne Venet, Alexandre Pachot, Guillaume Monneret, Frederic Reynier, Christophe Védrine, Philippe Leissner, Virginie Moucadel, Alain Lepape…

    Citation: Intensive Care Medicine Experimental 2019 7:28

    Content type: Research

    Published on:

  19. Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in intensive care units. Distal airway mucus clearance has been shown to reduce VAP incidence. Studies suggest that mucus clearance...

    Authors: Melissa Mahajan, David DiStefano, Joshua Satalin, Penny Andrews, Hassan al-Khalisy, Sarah Baker, Louis A. Gatto, Gary F. Nieman and Nader M. Habashi

    Citation: Intensive Care Medicine Experimental 2019 7:27

    Content type: Research

    Published on:

  20. Conduit arteries, especially the aorta, play a major role in ensuring efficient cardiac function and optimal microvascular flow due to their viscoelastic properties. Studies in animals and on isolated arteries...

    Authors: Sigita Kazune, Andris Grabovskis, Corrado Cescon, Eva Strike and Indulis Vanags

    Citation: Intensive Care Medicine Experimental 2019 7:26

    Content type: Research

    Published on:

  21. Sepsis still represents a major health issue, with persistent high morbidity and mortality rates. Cardiovascular dysfunction occurs frequently during sepsis. Adrenomedullin has been identified as a key mediato...

    Authors: Alice Blet, Benjamin Deniau, Christopher Geven, Malha Sadoune, Anaïs Caillard, Paul-Robert Kounde, Evelyne Polidano, Peter Pickkers, Jane-Lise Samuel and Alexandre Mebazaa

    Citation: Intensive Care Medicine Experimental 2019 7:25

    Content type: Research

    Published on:

  22. Following publication of the original article [1], the authors flagged that an incorrect piece of data is given in the Materials and Methods section of the article.

    Authors: A. Otterbeck, K. Hanslin, E. Lidberg Lantz, A. Larsson, J. Stålberg and M. Lipcsey

    Citation: Intensive Care Medicine Experimental 2019 7:24

    Content type: Correction

    Published on:

    The original article was published in Intensive Care Medicine Experimental 2019 7:21

  23. To maintain adequate oxygen delivery to tissue, resuscitation of critically ill patients is guided by assessing surrogate markers of perfusion. As there is no direct indicator of cerebral perfusion used in rou...

    Authors: Michael D. Wood, Jill A. Jacobson, David M. Maslove, John G. Muscedere and J. Gordon Boyd

    Citation: Intensive Care Medicine Experimental 2019 7:23

    Content type: Research

    Published on:

  24. P. aeruginosa is a pathogen frequently resistant to antibiotics and a common cause of ventilator-associated pneumonia (VAP). Non-antibiotic strategies to prevent or treat VAP are therefore of major interest. Spec...

    Authors: A. Otterbeck, K. Hanslin, E. Lidberg Lantz, A. Larsson, J. Stålberg and M. Lipcsey

    Citation: Intensive Care Medicine Experimental 2019 7:21

    Content type: Research

    Published on:

    The Correction to this article has been published in Intensive Care Medicine Experimental 2019 7:24

  25. Current clinical practice during high-flow nasal therapy (HFNT) involves utilization of a nasal cannula to provide humidification, with a facemask placed over the cannula to deliver aerosol. Few studies have c...

    Authors: Gavin Bennett, Mary Joyce, Elena Fernández Fernández and Ronan MacLoughlin

    Citation: Intensive Care Medicine Experimental 2019 7:20

    Content type: Research

    Published on:

  26. In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to rev...

    Authors: Frank Silva Bezerra, Camila de Oliveira Ramos, Thalles de Freitas Castro, Natália Pereira da Silva Araújo, Ana Beatriz Farias de Souza, Ana Carla Balthar Bandeira, Guilherme de Paula Costa, Christiane Teixeira Cartelle, André Talvani, Sílvia Dantas Cangussú, Laurent Brochard and Akinori Cardozo Nagato

    Citation: Intensive Care Medicine Experimental 2019 7:19

    Content type: Research

    Published on:

  27. Extracorporeal membrane oxygenation (ECMO) is an increasingly accepted means of supporting those with severe acute respiratory distress syndrome (ARDS). Given the high mortality associated with ARDS, numerous ...

    Authors: Jonathan E. Millar, Nicole Bartnikowski, Viktor von Bahr, Maximilian V. Malfertheiner, Nchafatso G. Obonyo, Mirko Belliato, Jacky Y. Suen, Alain Combes, Daniel F. McAuley, Roberto Lorusso and John F. Fraser

    Citation: Intensive Care Medicine Experimental 2019 7:18

    Content type: Review

    Published on:

  28. Veno-venous extracorporeal carbon dioxide (CO2) removal (vv-ECCO2R) is increasingly being used in the setting of acute respiratory failure. Blood flow rates range in clinical practice from 200 mL/min to more than...

    Authors: Stephan Strassmann, Michaela Merten, Simone Schäfer, Jonas de Moll, Daniel Brodie, Anders Larsson, Wolfram Windisch and Christian Karagiannidis

    Citation: Intensive Care Medicine Experimental 2019 7:17

    Content type: Research

    Published on:

  29. Noninvasive online monitoring of different particle flows from the airways may serve as an additional tool to assess mechanical ventilation. In the present study, we used a customised PExA, an optical particle...

    Authors: Ellen Broberg, Leif Pierre, Mohammed Fakhro, Lars Algotsson, Malin Malmsjö, Snejana Hyllén and Sandra Lindstedt

    Citation: Intensive Care Medicine Experimental 2019 7:16

    Content type: Research

    Published on:

  30. Two recent large randomized controlled trials did not show the superiority of high-frequency oscillatory ventilation (HFOV) in adults with ARDS. These two trials had differing results, and possible causes coul...

    Authors: Tetsuya Yumoto, Takahisa Fujita, Sunao Asaba, Shunsuke Kanazawa, Atsunori Nishimatsu, Hideo Yamanouchi, Satoshi Nakagawa and Osamu Nagano

    Citation: Intensive Care Medicine Experimental 2019 7:15

    Content type: Research

    Published on:

  31. Kinins are short peptides with a wide range of proinflammatory properties that are generated from kininogens in the so-called kallikrein-kinin system. Kinins exert their biological activities through stimulati...

    Authors: Chao Ding, Jack Yang, Cornelis van’t Veer and Tom van der Poll

    Citation: Intensive Care Medicine Experimental 2019 7:14

    Content type: Research

    Published on:

  32. Recent studies in haemodynamic management have focused on fluid management and assessed its effects in terms of increase in cardiac output based on fluid challenges or variations in pulse pressure caused by cy...

    Authors: S. Sondergaard, J. S. Larsson and P. W. Möller

    Citation: Intensive Care Medicine Experimental 2019 7:13

    Content type: Research

    Published on:

  33. The provision of guidance in ventilator therapy by continuous monitoring of regional lung ventilation, aeration and respiratory system mechanics is the main clinical benefit of electrical impedance tomography ...

    Authors: Inéz Frerichs, Peter A. Dargaville and Peter C. Rimensberger

    Citation: Intensive Care Medicine Experimental 2019 7:11

    Content type: Research

    Published on:

  34. Endotracheal tubes used for neonates are not as resistant to breathing as originally anticipated; therefore, spontaneous breathing trials (SBTs) with continuous positive airway pressure (CPAP), without pressur...

    Authors: Makoto Sasaki, Yoshikazu Yamaguchi, Tetsuya Miyashita, Yuko Matsuda, Masahide Ohtsuka, Osamu Yamaguchi and Takahisa Goto

    Citation: Intensive Care Medicine Experimental 2019 7:10

    Content type: Research

    Published on:

  35. Percutaneous dilatational tracheostomy (PDT) is the most frequently performed procedure in patients requiring prolonged mechanical ventilation. A crucial step in such procedures is needle insertion into the tr...

    Authors: Alessandro Terrani, Enrico Bassi, Caterina Valcarenghi, Emmanuel Charbonney, Paul Ouellet, Patrice Gosselin, Giacomo Bellani and Giuseppe Foti

    Citation: Intensive Care Medicine Experimental 2019 7:9

    Content type: Research

    Published on:

  36. Ventilator-induced diaphragmatic dysfunction (VIDD) is a common event during mechanical ventilation (MV) leading to rapid muscular atrophy and contractile dysfunction. Recent data show that renin-angiotensin s...

    Authors: Vanessa Zambelli, Anna Sigurtà, Laura Rizzi, Letizia Zucca, Paolo Delvecchio, Elena Bresciani, Antonio Torsello and Giacomo Bellani

    Citation: Intensive Care Medicine Experimental 2019 7:8

    Content type: Research

    Published on:

  37. Positive pressure ventilation can decrease venous return and cardiac output. It is not known if expiratory ventilation assistance (EVA) through a small endotracheal tube can improve venous return and cardiac o...

    Authors: David A. Berlin, Seth Manoach, Clara Oromendia and Paul M. Heerdt

    Citation: Intensive Care Medicine Experimental 2019 7:6

    Content type: Research

    Published on:

  38. Evidence suggests that early adaptive responses of hepatic mitochondria occur in experimentally induced sepsis. Little is known about both colonic mitochondrial function during abdominal infection and long-ter...

    Authors: Anna Herminghaus, Henrike Papenbrock, Rebecca Eberhardt, Christian Vollmer, Richard Truse, Jan Schulz, Inge Bauer, Adelheid Weidinger, Andrey V. Kozlov, Johnny Stiban and Olaf Picker

    Citation: Intensive Care Medicine Experimental 2019 7:4

    Content type: Research

    Published on:

  39. Microcirculation dysfunction with blood flow heterogeneity is an important characteristic in sepsis shock. We hypothesized that impaired ability of red blood cells to release nitric oxide resulted in microcirc...

    Authors: Bo Yao, Da-Wei Liu, Wen-Zhao Chai, Xiao-Ting Wang and Hong-Min Zhang

    Citation: Intensive Care Medicine Experimental 2019 7:1

    Content type: Research

    Published on:

  40. Haemostasis and correction of hypovolemia are the pillars of early haemorrhage shock (HS) management. Vasopressors, which are not recommended as first-line therapy, are an alternative to aggressive fluid resus...

    Authors: Sophie Dunberry-Poissant, Kim Gilbert, Caroline Bouchard, Frédérique Baril, Anne-Marie Cardinal, Sydnée L’Ecuyer, Mathieu Hylands, François Lamontagne, Guy Rousseau and Emmanuel Charbonney

    Citation: Intensive Care Medicine Experimental 2018 6:47

    Content type: Research

    Published on:

  41. Cerebral regional microcirculation is altered following severe head injury. In addition to tissue disruption, partial pressure of tissue oxygenation is impaired due to an increase in the oxygen tissue gradient...

    Authors: Judith Bellapart, Kylie Cuthbertson, Kimble Dunster, Sara Diab, David G. Platts, Christopher Raffel, Levon Gabrielian, Adrian Barnett, Jennifer Paratz, Rob Boots and John F. Fraser

    Citation: Intensive Care Medicine Experimental 2018 6:46

    Content type: Research

    Published on:

  42. Selective brain cooling (SBC) methods could alleviate the complications associated with systemic hypothermia. The authors (MFB, LK, and T-YL) have developed a simple and an effective nasopharyngeal SBC method ...

    Authors: Mohammad Fazel Bakhsheshi, Lynn Keenliside and Ting-Yim Lee

    Citation: Intensive Care Medicine Experimental 2018 6:45

    Content type: Research

    Published on: