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  1. The pressure-recording analytical method is a new semi-invasive method for cardiac output measurement (PRAM). There are no studies comparing this technique with femoral artery thermodilution (FATD) in an infan...

    Authors: Javier Urbano, Jorge López, Rafael González, Sarah N. Fernández, María José Solana, Blanca Toledo, Ángel Carrillo and Jesús López-Herce
    Citation: Intensive Care Medicine Experimental 2016 4:13
    Content type: Research Published on:

  2. The recent discovery of cell cycle arrest biomarkers, tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7), has led to a newly available clinical test for a...

    Authors: Zhi-Yong Peng, Feihu Zhou and John A. Kellum
    Citation: Intensive Care Medicine Experimental 2016 4:12
    Content type: Research Published on:

  3. Airway pressure release ventilation (APRV) was first described in 1987 and defined as continuous positive airway pressure (CPAP) with a brief release while allowing the patient to spontaneously breathe through...

    Authors: Sumeet V. Jain, Michaela Kollisch-Singule, Benjamin Sadowitz, Luke Dombert, Josh Satalin, Penny Andrews, Louis A. Gatto, Gary F. Nieman and Nader M. Habashi
    Citation: Intensive Care Medicine Experimental 2016 4:11
    Content type: Review Published on:

  4. Reduced motor and sensory nerve amplitudes in critical illness polyneuropathy (CIP) are characteristic features described in electrophysiological studies and due to dysfunction of voltage-gated sodium channels...

    Authors: Susanne Koch, Jeffrey Bierbrauer, Kurt Haas, Simone Wolter, Julian Grosskreutz, Friedrich C. Luft, Claudia D. Spies, Jens Fielitz and Steffen Weber-Carstens
    Citation: Intensive Care Medicine Experimental 2016 4:10
    Content type: Research Published on:

  5. Serum biomarkers may play a role in prognostication after cardiac arrest. This study was designed to assess the feasibility of using two-dimensional gel electrophoresis (2D-GE) coupled with mass spectrometry (...

    Authors: J. Gordon Boyd, Laura J. Smithson, Daniel Howes, John Muscedere and Michael D. Kawaja
    Citation: Intensive Care Medicine Experimental 2016 4:9
    Content type: Research Published on:

  6. Hypercapnia, with its associated acidosis (HCA), is a consequence of respiratory failure and is also seen in critically ill patients managed with conventional “protective” ventilation strategies. Nuclear facto...

    Authors: Shahd Horie, Bilal Ansari, Claire Masterson, James Devaney, Michael Scully, Daniel O’Toole and John G. Laffey
    Citation: Intensive Care Medicine Experimental 2016 4:8
    Content type: Research Published on:

  7. Echocardiography is a key investigation in the management of patients on extracorporeal membrane oxygenation (ECMO). However, echocardiographic images are often non-diagnostic in this patient population. Contr...

    Authors: David G. Platts, Charles McDonald, Kiran Shekar, Darryl J. Burstow, Daniel Mullany, Marc Ziegenfuss, Sara Diab and John F. Fraser
    Citation: Intensive Care Medicine Experimental 2016 4:7
    Content type: Research Published on:

  8. Early use of fresh frozen plasma (FFP) in haemorrhagic shock is associated with improved outcome. This effect may partly be due to protection of the endothelial glycocalyx and/or secondary to a superior effica...

    Authors: Axel Nelson, Svajunas Statkevicius, Ulf Schött, Pär I. Johansson and Peter Bentzer
    Citation: Intensive Care Medicine Experimental 2016 4:6
    Content type: Research Published on:

  9. The nature of the inflammatory response underscoring the pathophysiology of sepsis has been extensively studied. We hypothesized that different cell functions would be differentially regulated in a patient wit...

    Authors: Sidnéia S. Santos, Amanda M. Carmo, Milena K. C. Brunialti, Flavia R. Machado, Luciano C. Azevedo, Murillo Assunção, Sílvia C. Trevelin, Fernando Q. Cunha and Reinaldo Salomao
    Citation: Intensive Care Medicine Experimental 2016 4:5
    Content type: Research Published on:

  10. Multiple organ failure, wasting, increased morbidity, and mortality following acute illness complicates the health span of patients surviving sepsis. Persistent inflammation has been implicated, and it is prop...

    Authors: Ata Murat Kaynar, Veli Bakalov, Silvia Martinez Laverde, Amélie I. F. Cambriel, Byoung-Hoon Lee, Atif Towheed, Alyssa D. Gregory, Steven A. R. Webb, Michael J. Palladino, Fernando A. Bozza, Steven D. Shapiro and Derek C. Angus
    Citation: Intensive Care Medicine Experimental 2016 4:4
    Content type: Research Published on:

  11. Cerebral cytoplasmatic redox state is a sensitive indicator of cerebral oxidative metabolism and is conventionally evaluated from the extracellular lactate/pyruvate (LP) ratio. In the present experimental stud...

    Authors: Rasmus Jakobsen, Troels Halfeld Nielsen, Asger Granfeldt, Palle Toft and Carl-Henrik Nordström
    Citation: Intensive Care Medicine Experimental 2016 4:3
    Content type: Research Published on:

  12. Extracorporeal carbon dioxide removal (ECCO2R) has been gaining interest to potentially facilitate gas transfer and equilibrate mild to moderate hypercapnic acidosis, when standard therapy with non-invasive venti...

    Authors: A. S. Sharma, P. W. Weerwind, O. Bekers, E. M. Wouters and J. G. Maessen
    Citation: Intensive Care Medicine Experimental 2016 4:2
    Content type: Research Published on:

  13. Extracorporeal membrane oxygenation (ECMO) is a technique widely used worldwide to improve gas exchange. Changes in ECMO settings affect both oxygen and carbon dioxide. The impact on oxygenation can be followe...

    Authors: Pedro Vitale Mendes, Marcelo Park, Alexandre Toledo Maciel, Débora Prudêncio e Silva, Natalia Friedrich, Edzangela Vasconcelos Santos Barbosa, Adriana Sayuri Hirota, Guilherme Pinto Paula Schettino, Luciano Cesar Pontes Azevedo and Eduardo Leite Vieira Costa
    Citation: Intensive Care Medicine Experimental 2016 4:1
    Content type: Research Published on:

  14. Intra-arrest hypothermia induction may provide more benefit than inducing hypothermia after return of spontaneous circulation. However, little is understood about the interaction between patient physiology and...

    Authors: Joshua W. Lampe, George Bratinov, Theodore R. Weiland III, Uday Illindala, Robert A. Berg and Lance B. Becker
    Citation: Intensive Care Medicine Experimental 2015 3:37
    Content type: Research Published on:

  15. The beneficial effects of heparin in the treatment of severe sepsis, septic shock, and sepsis-associated disseminated intravascular coagulation (DIC) have recently been reported. However, the mechanisms underl...

    Authors: Toshiaki Iba, Naoyuki Hashiguchi, Isao Nagaoka, Yoko Tabe, Katsuhiko Kadota and Koichi Sato
    Citation: Intensive Care Medicine Experimental 2015 3:36
    Content type: Research Published on:

  16. Lung injury is often studied without consideration for pathologic changes in the chest wall. In order to reduce the incidence of lung injury using preemptive mechanical ventilation, it is important to recogniz...

    Authors: Michaela Kollisch-Singule, Bryanna Emr, Sumeet V. Jain, Penny Andrews, Joshua Satalin, Jiao Liu, Elizabeth Porcellio, Van Kenyon, Guirong Wang, William Marx, Louis A. Gatto, Gary F. Nieman and Nader M. Habashi
    Citation: Intensive Care Medicine Experimental 2015 3:35
    Content type: Research Published on:

  17. High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. We aimed to find the volumetric VILI threshold and see whether PEEP i...

    Authors: Alessandro Protti, Davide T. Andreis, Marta Milesi, Giacomo E. Iapichino, Massimo Monti, Beatrice Comini, Paola Pugni, Valentina Melis, Alessandro Santini, Daniele Dondossola, Stefano Gatti, Luciano Lombardi, Emiliano Votta, Eleonora Carlesso and Luciano Gattinoni
    Citation: Intensive Care Medicine Experimental 2015 3:34
    Content type: Research Published on:

  18. A recent prospective trial using porcine models of severe acute respiratory distress syndrome (ARDS) indicated that positive-pressure ventilation delivered by a conventional intensive care ventilator at a mode...

    Authors: Wenfei Wang, Anup Das, Oanna Cole, Marc Chikhani, Jonathan G. Hardman and Declan G. Bates
    Citation: Intensive Care Medicine Experimental 2015 3:33
    Content type: Research Published on:

  19. Blast lung injuries (BLI) caused by blast waves are extremely critical in the prehospital setting, and hypotension is thought to be the main cause of death in such cases. The present study aimed to elucidate t...

    Authors: Hiroki Miyawaki, Daizoh Saitoh, Kohsuke Hagisawa, Midori Noguchi, Shunichi Sato, Manabu Kinoshita, Hiromi Miyazaki, Yasushi Satoh, Nahoko Harada and Toshihisa Sakamoto
    Citation: Intensive Care Medicine Experimental 2015 3:32
    Content type: Research Published on:

  20. Upregulation of the endothelin axis has been observed in pulmonary tissue after brain death, contributing to primary graft dysfunction and ischaemia reperfusion injury. The current study aimed to develop a nov...

    Authors: Ryan P. Watts, Izabela Bilska, Sara Diab, Kimble R. Dunster, Andrew C. Bulmer, Adrian G. Barnett and John F. Fraser
    Citation: Intensive Care Medicine Experimental 2015 3:31
    Content type: Research Published on:

  21. Several mechanisms are associated with brain dysfunction during sepsis; one of the most important are activation of microglia and astrocytes. Activation of glial cells induces changes in permeability of the bl...

    Authors: Monique Michels, Amanda V. Steckert, João Quevedo, Tatiana Barichello and Felipe Dal-Pizzol
    Citation: Intensive Care Medicine Experimental 2015 3:30
    Content type: Review Published on:

  22. The potential for mesenchymal stem cells (MSCs) to reduce the severity of experimental lung injury has been established in several pre-clinical studies. We have recently demonstrated that MSCs, and MSC-secrete...

    Authors: Mairead Hayes, Gerard F. Curley, Claire Masterson, James Devaney, Daniel O’Toole and John G. Laffey
    Citation: Intensive Care Medicine Experimental 2015 3:29
    Content type: Research Published on:

  29. Authors: V Gulia, A Goel, S Kumari, R Kumari and N Arora
    Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A858
    Content type: Poster presentation Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

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  • ISSN: 2197-425X (electronic)