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  1. Outcome prediction in critically ill patients under invasive ventilation remains extremely challenging. The driving pressure (ΔP) and the mechanical power of ventilation (MP) are associated with patient-center...

    Authors: David M. P. van Meenen, Ary Serpa Neto, Frederique Paulus, Coen Merkies, Laura R. Schouten, Lieuwe D. Bos, Janneke Horn, Nicole P. Juffermans, Olaf L. Cremer, Tom van der Poll and Marcus J. Schultz
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):60

    This article is part of a Supplement: Volume 8 Supplement 1

  2. Patients with liver diseases are at high risk for the development of acute respiratory distress syndrome (ARDS). The liver is an important organ that regulates a complex network of mediators and modulates orga...

    Authors: Raquel Herrero, Gema Sánchez, Iris Asensio, Eva López, Antonio Ferruelo, Javier Vaquero, Laura Moreno, Alba de Lorenzo, Rafael Bañares and José A. Lorente
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):48

    This article is part of a Supplement: Volume 8 Supplement 1

  3. Alkaline phosphatase (AP), a dephosphorylating enzyme, is involved in various physiological processes and has been shown to have anti-inflammatory effects.

    Authors: Jenny Juschten, Sarah A. Ingelse, Lieuwe D. J. Bos, Armand R. J. Girbes, Nicole P. Juffermans, Tom van der Poll, Marcus J. Schultz and Pieter Roel Tuinman
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):46

    This article is part of a Supplement: Volume 8 Supplement 1

  4. In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction o...

    Authors: Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings and Nicole P. Juffermans
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):42

    This article is part of a Supplement: Volume 8 Supplement 1

  5. Glucocorticoids (GCs) are stress hormones that regulate developmental and physiological processes and are among the most potent anti-inflammatory drugs to suppress chronic and acute inflammation. GCs act throu...

    Authors: Martin Wepler, Jonathan M. Preuss, Tamara Merz, Oscar McCook, Peter Radermacher, Jan P. Tuckermann and Sabine Vettorazzi
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):37

    This article is part of a Supplement: Volume 8 Supplement 1

  6. In acute respiratory distress syndrome (ARDS), increased pulmonary vascular permeability makes the lung vulnerable to edema. The use of conservative as compared to liberal fluid strategies may increase the num...

    Authors: Renata de S. Mendes, Paolo Pelosi, Marcus J. Schultz, Patricia R. M. Rocco and Pedro L. Silva
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):32

    This article is part of a Supplement: Volume 8 Supplement 1

  7. Immune cell activation leads to the acquisition of new functions, such as proliferation, chemotaxis, and cytokine production. These functional changes require continuous metabolic adaption in order to sustain ...

    Authors: Xiaomin Zhang, Fabian Zink, Felix Hezel, Josef Vogt, Ulrich Wachter, Martin Wepler, Maurizio Loconte, Christine Kranz, Andreas Hellmann, Boris Mizaikoff, Peter Radermacher and Clair Hartmann
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):28

    This article is part of a Supplement: Volume 8 Supplement 1

  8. Extracellular vesicles (EVs) are small, lipid bilayer-delimited particles of cellular origin that recently gained increasing attention for their potential use as diagnostic biomarkers, and beyond that for thei...

    Authors: Felix Behrens, Johannes Holle, Wolfgang M. Kuebler and Szandor Simmons
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):22

    This article is part of a Supplement: Volume 8 Supplement 1

  9. Sepsis is a syndrome of shock and dysfunction of multiple vital organs that is caused by an uncontrolled immune response to infection and has a high mortality rate. There are no therapies for sepsis, and it ha...

    Authors: Jack Brady, Shahd Horie and John G. Laffey
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):20

    This article is part of a Supplement: Volume 8 Supplement 1

  10. Post cardiac arrest syndrome is associated with high morbidity and mortality, which is related not only to a poor neurological outcome but also to respiratory and cardiovascular dysfunctions. The control of ga...

    Authors: Chiara Robba, Dorota Siwicka-Gieroba, Andras Sikter, Denise Battaglini, Wojciech Dąbrowski, Marcus J. Schultz, Evert de Jonge, Chloe Grim, Patricia RM Rocco and Paolo Pelosi
    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):19

    This article is part of a Supplement: Volume 8 Supplement 1

  11. Targeted hypothermia, as used after cardiac arrest, increases electrical and mechanical systolic duration. Differences in duration of electrical and mechanical systole are correlated to ventricular arrhythmias...

    Authors: Kristin Wisløff-Aase, Viesturs Kerans, Kristina Haugaa, Per Steinar Halvorsen, Helge Skulstad and Andreas Espinoza
    Citation: Intensive Care Medicine Experimental 2020 8:76
  12. COVID19 is caused by the SARS-CoV-2 virus and has been associated with severe inflammation leading to organ dysfunction and mortality. Our aim was to profile the transcriptome in leukocytes from critically ill...

    Authors: Sean E. Gill, Claudia C. dos Santos, David B. O’Gorman, David E. Carter, Eric K. Patterson, Marat Slessarev, Claudio Martin, Mark Daley, Michael R. Miller, Gediminas Cepinskas and Douglas D. Fraser
    Citation: Intensive Care Medicine Experimental 2020 8:75
  13. When severe, COVID-19 shares many clinical features with bacterial sepsis. Yet, secondary bacterial infection is uncommon. However, as epithelium is injured and barrier function is lost, bacterial products ent...

    Authors: Phatadon Sirivongrangson, Win Kulvichit, Sunchai Payungporn, Trairak Pisitkun, Ariya Chindamporn, Sadudee Peerapornratana, Prapaporn Pisitkun, Suwalak Chitcharoen, Vorthon Sawaswong, Navaporn Worasilchai, Sarinya Kampunya, Opass Putcharoen, Thammasak Thawitsri, Nophol Leelayuwatanakul, Napplika Kongpolprom, Vorakamol Phoophiboon…
    Citation: Intensive Care Medicine Experimental 2020 8:72
  14. Ex vivo lung perfusion (EVLP) is a widespread accepted platform for preservation and evaluation of donor lungs prior to lung transplantation (LTx). Standard lungs are ventilated using volume-controlled ventila...

    Authors: Sofie Ordies, Michaela Orlitova, Tobias Heigl, Annelore Sacreas, Anke Van Herck, Janne Kaes, Berta Saez, Arno Vanstapel, Laurens Ceulemans, Bart M. Vanaudenaerde, Robin Vos, Johny Verschakelen, Geert M. Verleden, Stijn E. Verleden, Dirk E. Van Raemdonck and Arne P. Neyrinck
    Citation: Intensive Care Medicine Experimental 2020 8:70
  15. Nosocomial infection contributes to adverse outcome after brain injury. This study investigates whether autonomic nervous system activity is associated with a decreased host immune response in patients followi...

    Authors: Mathijs R. Wirtz, Jiri Moekotte, Kirsten Balvers, Marjolein M. Admiraal, Jean-Francois Pittet, Joe Colombo, Brant M. Wagener, J. Carel Goslings and Nicole Juffermans
    Citation: Intensive Care Medicine Experimental 2020 8:69
  16. Intensive care unit workers are at high risk of acquiring COVID-19 infection, especially when performing invasive techniques and certain procedures that generate aerosols (< 5 μm). Therefore, one of the object...

    Authors: Dolores Escudero, José Antonio Boga, Javier Fernández, Lorena Forcelledo, Salvador Balboa, Rodrigo Albillos, Iván Astola, Emilio García-Prieto, Marta Elena Álvarez-Argüelles, Gabriel Martín, Josu Jiménez and Fernando Vázquez
    Citation: Intensive Care Medicine Experimental 2020 8:68
  17. Lethal B. anthracis infection produces high proinflammatory peptidoglycan (PGN) burdens in hosts. We investigated whether the lethality and inflammation anthrax PGN can produce are related.

    Authors: Yan Li, Xizhong Cui, Joseph Shiloach, Jeffrey Wang, Dante A. Suffredini, Wanying Xu, Wancang Liu, Yvonne Fitz, Junfeng Sun and Peter Q. Eichacker
    Citation: Intensive Care Medicine Experimental 2020 8:67
  18. Traumatic brain injury (TBI) is one of the most frequent and severe neurological diseases. In the last few decades, significant advances have been made in TBI pathophysiology and monitoring, however new treatm...

    Authors: Enrique Martinez-Gonzalez, Dolores Garcia-Olmo, Empar Mayordomo-Aranda, Maria Granada-Picazo, Monica Gomez-Juarez and Jeronimo Moreno-Cuesta
    Citation: Intensive Care Medicine Experimental 2020 8:66
  19. Venous–arterial carbon dioxide (CO2) to arterial–venous oxygen (O2) content difference ratio (Cv-aCO2/Ca-vO2) > 1 is supposed to be both sensitive and specific for anaerobic metabolism. What regional hemodynamic ...

    Authors: Thiago Domingos Corrêa, Adriano José Pereira, Jukka Takala and Stephan Mathias Jakob
    Citation: Intensive Care Medicine Experimental 2020 8:64
  20. There are limited therapeutic options directed at the underlying pathological processes in acute respiratory distress syndrome (ARDS). Experimental therapeutic strategies have targeted the protective systems t...

    Authors: Robert Qaqish, Yui Watanabe, Marcos Galasso, Cara Summers, A adil Ali, Mamoru Takahashi, Anajara Gazzalle, Mingyao Liu, Shaf Keshavjee, Marcelo Cypel and Lorenzo Del Sorbo
    Citation: Intensive Care Medicine Experimental 2020 8:63
  21. Existing clinical practice guidelines support the use of neuromuscular blocking agents (NMBA) in acute respiratory distress syndrome (ARDS); however, a recent large randomized clinical trial (RCT) has question...

    Authors: Nehal Tarazan, Moayad Alshehri, Sameer Sharif, Zainab Al Duhailib, Morten Hylander Møller, Emilie Belley-Cote, Mohammed Alshahrani, John Centofanti, Lauralyn McIntyre, Bandar Baw, Maureen Meade and Waleed Alhazzani
    Citation: Intensive Care Medicine Experimental 2020 8:61
  22. Early treatment of severe hyperglycemia involves large shifts of body fluids that entail a risk of hemodynamic instability. We studied the feasibility of applying a new electrolyte equation that estimates the ...

    Authors: Robert Svensson, Joachim Zdolsek, Marcus Malm and Robert G. Hahn
    Citation: Intensive Care Medicine Experimental 2020 8:59
  23. Stroke volume measurement should provide estimates of acute treatment responses. The current pulse contour method estimates left ventricle stroke volume. Heart-lung interactions change right ventricular stroke...

    Authors: David Berger, Jan Hobi, Per W. Möller, Matthias Haenggi, Jukka Takala and Stephan M. Jakob
    Citation: Intensive Care Medicine Experimental 2020 8:58
  24. Authors: Emma M. Chang, Andrew Bretherick, Gordon B. Drummond and J. Kenneth Baillie
    Citation: Intensive Care Medicine Experimental 2020 8:57

    The Letter to the Editor to this article has been published in Intensive Care Medicine Experimental 2020 8:27

  25. The ex vivo human perfused lung model has enabled optimizing donor lungs for transplantation and delineating mechanisms of lung injury. Perfusate and airspace biomarkers are a proxy of the lung response to exp...

    Authors: Aleksandra Leligdowicz, James T. Ross, Nicolas Nesseler and Michael A. Matthay
    Citation: Intensive Care Medicine Experimental 2020 8:56
  26. Change of the corrected flow time (Ftc) is a surrogate for tracking stroke volume (SV) in the intensive care unit. Multiple Ftc equations have been proposed; many have not had their diagnostic characteristics ...

    Authors: Jon-Émile S. Kenny, Igor Barjaktarevic, David C. Mackenzie, Andrew M. Eibl, Matthew Parrotta, Bradley F. Long and Joseph K. Eibl
    Citation: Intensive Care Medicine Experimental 2020 8:54
  27. Immunological dysfunction is common in critically ill patients but its clinical significance and the optimal method to measure it are unknown. The level of tumor necrosis factor alpha (TNF-α) after ex-vivo who...

    Authors: Gabrielle Levin, J. Gordon Boyd, Andrew Day, Miranda Hunt, David M. Maslove, Patrick Norman, Nicole O’Callaghan, Stephanie Sibley and John Muscedere
    Citation: Intensive Care Medicine Experimental 2020 8:55
  28. Extracorporeal carbon dioxide removal (ECCO2R) is a promising yet limited researched therapy for hypercapnic respiratory failure in acute respiratory distress syndrome and exacerbated chronic obstructive pulmonar...

    Authors: Leonie S. Schwärzel, Anna M. Jungmann, Nicole Schmoll, Frederik Seiler, Ralf M. Muellenbach, Joachim Schenk, Quoc Thai Dinh, Robert Bals, Philipp M. Lepper and Albert J. Omlor
    Citation: Intensive Care Medicine Experimental 2020 8:52
  29. Heparin-binding protein (HBP) is a neutrophil-derived pro-inflammatory protein, an inducer of endothelial dysfunction and vascular permeability and a promising prognostic biomarker in sepsis. This exploratory ...

    Authors: Jonas Tverring, Niklas Nielsen, Josef Dankiewicz, Adam Linder, Fredrik Kahn and Per Åkesson
    Citation: Intensive Care Medicine Experimental 2020 8:51
  30. Pseudo-pulseless electrical activity (pseudo-PEA) is a lifeless form of profound cardiac shock characterized by measurable cardiac mechanical activity without clinically detectable pulses. Pseudo-PEA may const...

    Authors: Alexander L. Lindqwister, Joshua W. Lampe, Jeffrey R. Gould, Christopher L. Kaufman, Karen L. Moodie and Norman A. Paradis
    Citation: Intensive Care Medicine Experimental 2020 8:50
  31. The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We hypothesized that differences in microbiota composition across vendor...

    Authors: Nora S. Wolff, Max C. Jacobs, Bastiaan W. Haak, Joris J. T. H. Roelofs, Alex F. de Vos, Floor Hugenholtz and W. Joost Wiersinga
    Citation: Intensive Care Medicine Experimental 2020 8:47
  32. Non-invasive and lung-protective ventilation techniques may improve outcomes for patients with an acute exacerbation of chronic obstructive pulmonary disease or moderate acute respiratory distress syndrome by ...

    Authors: Alexandra G. May, Ryan A. Orizondo, Brian J. Frankowski, Sang-Ho Ye, Ergin Kocyildirim, William R. Wagner, Jonathan D’Cunha and William J. Federspiel
    Citation: Intensive Care Medicine Experimental 2020 8:45
  33. Alteration of the mechanisms of cerebral blood flow (CBF) regulation might contribute to the pathophysiology of sepsis-associated encephalopathy (SAE). However, previous clinical studies on dynamic cerebral au...

    Authors: Lorenzo Ferlini, Fuhong Su, Jacques Creteur, Fabio Silvio Taccone and Nicolas Gaspard
    Citation: Intensive Care Medicine Experimental 2020 8:44
  34. This study aimed to assess right ventricular (RV) function during cardiogenic shock due to acute left ventricular (LV) failure, including during LV unloading with Impella CP and an added moderate dose of norep...

    Authors: Jakob Josiassen, Ole Kristian Lerche Helgestad, Nanne Louise Junker Udesen, Ann Banke, Peter Hartmund Frederiksen, Janus Adler Hyldebrandt, Henrik Schmidt, Lisette Okkels Jensen, Christian Hassager, Hanne Berg Ravn and Jacob E. Møller
    Citation: Intensive Care Medicine Experimental 2020 8:41
  35. Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies. To ensure that new therapies ...

    Authors: Jane Fisher, Chiara Pavan, Luisa S. Ohlmeier, Bo Nilson, Iben Lundgaard, Adam Linder and Peter Bentzer
    Citation: Intensive Care Medicine Experimental 2020 8:40
  36. Positive end-expiratory pressure (PEEP) is used to optimize oxygenation by preventing alveolar collapse. However, PEEP can potentially decrease cardiac output through cardiopulmonary interactions. The effect o...

    Authors: Yosef Levenbrown, Md Jobayer Hossain, James P. Keith, Katlyn Burr, Anne Hesek and Thomas Shaffer
    Citation: Intensive Care Medicine Experimental 2020 8:36
  37. Noise levels on intensive care units (ICUs) are typically elevated. While many studies reported negative effects of ICU ambient sounds on patients, only few investigated noise as a factor to influence well-bei...

    Authors: Nadine Schmidt, Stephan M. Gerber, Björn Zante, Tom Gawliczek, Alvin Chesham, Klemens Gutbrod, René M. Müri, Tobias Nef, Joerg C. Schefold and Marie-Madlen Jeitziner
    Citation: Intensive Care Medicine Experimental 2020 8:34
  38. Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.

    Authors: Clifford S. Deutschman, Judith Hellman, Ricard Ferrer Roca, Daniel De Backer and Craig M. Coopersmith
    Citation: Intensive Care Medicine Experimental 2020 8:31
  39. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Emma M. Chang, Andrew Bretherick, Gordon B. Drummond and J. Kenneth Baillie
    Citation: Intensive Care Medicine Experimental 2020 8:30

    The original article was published in Intensive Care Medicine Experimental 2019 7:49

  40. Authors: Philip J. Peyton and Luke R. Fletcher
    Citation: Intensive Care Medicine Experimental 2020 8:27

    The original article was published in Intensive Care Medicine Experimental 2019 7:49

    The Letter to the Editor to this article has been published in Intensive Care Medicine Experimental 2020 8:57

  41. Primary blast lung injury (PBLI) presents as a syndrome of respiratory distress and haemoptysis resulting from explosive shock wave exposure and is a frequent cause of mortality and morbidity in both military ...

    Authors: Timothy E. Scott, Anup Das, Mainul Haque, Declan G. Bates and Jonathan G. Hardman
    Citation: Intensive Care Medicine Experimental 2020 8:26
  42. Plasma-Lyte is a balanced, crystalloid intravenous fluid which has been shown to avoid the hyperchloremic metabolic acidosis associated with 0.9% sodium chloride. Data on physical, pH and chemical compatibilit...

    Authors: Sophie Hammond, Andrew Wignell, Paul Cooling, David A. Barrett and Patrick Davies
    Citation: Intensive Care Medicine Experimental 2020 8:25
  43. 3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) abuse is frequent, and overdosing might cause severe and eventually lethal multi-organ failure. To date, there is no causal therapy of MDMA intoxication and ...

    Authors: Corinna N. Lang, Michaela J. Sommer, Merja A. Neukamm, Dawid L. Staudacher, Alexander Supady, Christoph Bode, Daniel Duerschmied and Achim Lother
    Citation: Intensive Care Medicine Experimental 2020 8:21