Articles

A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis

Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies. To ensure that new therapies ...

Authors: Jane Fisher, Chiara Pavan, Luisa S. Ohlmeier, Bo Nilson, Iben Lundgaard, Adam Linder and Peter Bentzer

CytoSorb removes MDMA in vitro, but is it an effective therapy in vivo?

3,4-Methylenedioxymethamphetamine intoxication can result in potentially lethal multi-organ failure, for which the current treatment is largely supportive. Recently, a report of the use of the CytoSorb device ...

Authors: Patrick M. Honore, Sebastien Redant and Thomas Datzmann

The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation

Positive end-expiratory pressure (PEEP) is used to optimize oxygenation by preventing alveolar collapse. However, PEEP can potentially decrease cardiac output through cardiopulmonary interactions. The effect o...

Authors: Yosef Levenbrown, Md Jobayer Hossain, James P. Keith, Katlyn Burr, Anne Hesek and Thomas Shaffer

ECMO cannula-associated infections: interest of cannula swab and subcutaneous needle aspirate samples for prediction of cannula tip culture

Authors: Hadrien Winiszewski, Charles Boyadjian, Guillaume Besch, Andrea Perrotti and Gaël Piton

Effects of intensive care unit ambient sounds on healthcare professionals: results of an online survey and noise exposure in an experimental setting

Noise levels on intensive care units (ICUs) are typically elevated. While many studies reported negative effects of ICU ambient sounds on patients, only few investigated noise as a factor to influence well-bei...

Authors: Nadine Schmidt, Stephan M. Gerber, Björn Zante, Tom Gawliczek, Alvin Chesham, Klemens Gutbrod, René M. Müri, Tobias Nef, Joerg C. Schefold and Marie-Madlen Jeitziner

The surviving sepsis campaign: basic/translational science research priorities

Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.

Authors: Clifford S. Deutschman, Judith Hellman, Ricard Ferrer Roca, Daniel De Backer and Craig M. Coopersmith

Correction to: Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients

An amendment to this paper has been published and can be accessed via the original article.

Authors: Emma M. Chang, Andrew Bretherick, Gordon B. Drummond and J. Kenneth Baillie

Water content of the endothelial glycocalyx layer estimated by volume kinetic analysis

The water volume of the endothelial glycocalyx layer has been estimated at 0.7 to 1.7 L using tracer methods of unclear value. The present study attempts to measure this fluid volume by analyzing the kinetics ...

Authors: Robert G. Hahn

Letter to the Editor: regarding “Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients”

Authors: Philip J. Peyton and Luke R. Fletcher

Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation

Primary blast lung injury (PBLI) presents as a syndrome of respiratory distress and haemoptysis resulting from explosive shock wave exposure and is a frequent cause of mortality and morbidity in both military ...

Authors: Timothy E. Scott, Anup Das, Mainul Haque, Declan G. Bates and Jonathan G. Hardman

Plasma-Lyte 148 and Plasma-Lyte 148 + 5% glucose compatibility with commonly used critical care drugs

Plasma-Lyte is a balanced, crystalloid intravenous fluid which has been shown to avoid the hyperchloremic metabolic acidosis associated with 0.9% sodium chloride. Data on physical, pH and chemical compatibilit...

Authors: Sophie Hammond, Andrew Wignell, Paul Cooling, David A. Barrett and Patrick Davies

Use of the CytoSorb adsorption device in MDMA intoxication: a first-in-man application and in vitro study

3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) abuse is frequent, and overdosing might cause severe and eventually lethal multi-organ failure. To date, there is no causal therapy of MDMA intoxication and ...

Authors: Corinna N. Lang, Michaela J. Sommer, Merja A. Neukamm, Dawid L. Staudacher, Alexander Supady, Christoph Bode, Daniel Duerschmied and Achim Lother

Analysis of blood culture in a rat model of cecal ligation and puncture induced sepsis

Authors: Prabakar Vaittinada Ayar, Hervé Jacquier, Benjamin Deniau, Feriel Azibani, Alexandre Mebazaa and Alice Blet

The importance of discovery science in the development of therapies for the critically ill

Discovery science, a term which encompasses basic, translational, and computational science with the aim to discover new therapies, has advanced critical care. By combining knowledge on inflammatory and genomi...

Authors: Nicole P. Juffermans, Peter Radermacher and John G. Laffey

Heart failure supported by veno-arterial extracorporeal membrane oxygenation (ECMO): a systematic review of pre-clinical models

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used to treat patients with refractory severe heart failure. Large animal models are developed to help understand physiology an...

Authors: Silver Heinsar, Sacha Rozencwajg, Jacky Suen, Gianluigi Li Bassi, Maximilian Malfertheiner, Leen Vercaemst, Lars Mikael Broman, Matthieu Schmidt, Alain Combes, Indrek Rätsep, John F. Fraser and Jonathan E. Millar

Method of respiratory rate measurement using a unique wearable platform and an adaptive optical-based approach

An efficient and accurate method of respiratory rate measurement is still missing in hospital general wards and triage. The goal of this study is to propose a method of respiratory rate measurement that has a ...

Authors: Gurpreet Singh, Augustine Tee, Thanawin Trakoolwilaiwan, Aza Taha and Malini Olivo

In vitro characterization of PrismaLung+: a novel ECCO₂R device

Invasive mechanical ventilation is lifesaving in the setting of severe acute respiratory failure but can cause ventilation-induced lung injury. Advances in extracorporeal CO₂ removal (ECCO₂R) technologies may fac...

Authors: Ingeborg Hospach, Jacques Goldstein, Kai Harenski, John G. Laffey, Dominique Pouchoulin, Manuela Raible, Stefanie Votteler and Markus Storr

Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke

Several therapeutic strategies to rescue the brain from ischemic injury have improved outcomes after stroke; however, there is no treatment as yet for reperfusion injury, the secondary damage caused by necessa...

Authors: Bruna Pescador Mendonça, Juliano Dos Santos Cardoso, Monique Michels, Ana Carolina Vieira, Diogo Wendhausen, Andressa Manfredini, Mervyn Singer, Felipe Dal-Pizzol and Alex Dyson

New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma

Patients often develop infectious complications after severe trauma. No biomarkers exist that enable early identification of patients who are at risk. Neutrophils are important immune cells that combat these i...

Authors: Lillian Hesselink, Roy Spijkerman, Emma de Fraiture, Suzanne Bongers, Karlijn J. P. Van Wessem, Nienke Vrisekoop, Leo Koenderman, Luke P. H. Leenen and Falco Hietbrink

Update of the organoprotective properties of xenon and argon: from bench to beside

The growth of the elderly population has led to an increase in patients with myocardial infarction and stroke (Wajngarten and Silva, Eur Cardiol 14: 111–115, 2019). Patients receiving treatment for ST-segment-...

Authors: Roehl Anna, Rossaint Rolf and Coburn Mark

Real-time effects of PEEP and tidal volume on regional ventilation and perfusion in experimental lung injury

Real-time bedside information on regional ventilation and perfusion during mechanical ventilation (MV) may help to elucidate the physiological and pathophysiological effects of MV settings in healthy and injur...

Authors: João Batista Borges, John N. Cronin, Douglas C. Crockett, Göran Hedenstierna, Anders Larsson and Federico Formenti

Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury

Sepsis, a dysregulated host response to infection with results in organ dysfunction, has been a major challenge to the development of effective therapeutics. Sepsis-associated acute kidney injury (S-AKI) resul...

Authors: Xiaoyan Wen, Shengnan Li, Alicia Frank, Xiukai Chen, David Emlet, Neil A. Hukriede and John A. Kellum

Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism

Human mesenchymal stem/stromal cells (hMSCs) represent a promising therapeutic strategy for ventilator-induced lung injury (VILI) and acute respiratory distress syndrome. Translational challenges include resto...

Authors: Shahd Horie, Sean Gaynard, Mary Murphy, Frank Barry, Michael Scully, Daniel O’Toole and John G. Laffey

Checkpoint inhibitor therapy in preclinical sepsis models: a systematic review and meta-analysis

Animal studies reporting immune checkpoint inhibitors (CPIs) improved host defense and survival during bacterial sepsis provided one basis for phase I CPI sepsis trials. We performed a systematic review and me...

Authors: Lindsay M. Busch, Junfeng Sun, Xizhong Cui, Peter Q. Eichacker and Parizad Torabi-Parizi

In vitro comparison between inspiration synchronized and continuous vibrating mesh nebulizer during trans-nasal aerosol delivery

Compared to continuous vibrating mesh nebulizer (VMN), inspiration synchronized VMN has shown increased inhaled dose during noninvasive ventilation; however, its use during aerosol delivery via high-flow nasal...

Authors: Jie Li, Wei Wu and James B. Fink

Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness

Hydrogen sulfide (H₂S) has long been known as a toxic environmental hazard. Discovery of physiological roles of H₂S as a neurotransmitter by Kimura and colleagues triggered an intensive research in the biological...

Authors: Eizo Marutani and Fumito Ichinose

Correction to: A case of intracoronary and endovenous levosimendan as a rescue therapy for refractory cardiac arrest

After publication of this supplement [1], it was brought to our attention that the author ‘L. Vegnuti’ has been erroneously omitted from the author list of the following abstract.

Authors: B. Ferro, R. Tofani, L. Vegnuti, G. Borelli, L. Gargani and P. Roncucci

Meta-analysis of targeted temperature management in animal models of cardiac arrest

Targeted temperature management (TTM) of 32 to 34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 indicated benefit on survival and neurological outcome. In ...

Authors: Hilmer Olai, Gustav Thornéus, Hannah Watson, Malcolm Macleod, Jonathan Rhodes, Hans Friberg, Niklas Nielsen, Tobias Cronberg and Tomas Deierborg

Carbon monoxide in intensive care medicine—time to start the therapeutic application?!

Carbon monoxide (CO) is not only known as a toxic gas due to its characteristics as an odorless molecule and its rapid binding to haem-containing molecules, thus inhibiting the respiratory chain in cells resul...

Authors: Ulrich Goebel and Jakob Wollborn

Aortic volume determines global end-diastolic volume measured by transpulmonary thermodilution

Global end-diastolic volume (GEDV) measured by transpulmonary thermodilution is regarded as indicator of cardiac preload. A bolus of cold saline injected in a central vein travels through the heart and lung, b...

Authors: Aleksej Akohov, Christoph Barner, Steffen Grimmer, Roland CE Francis and Stefan Wolf

Intracellular calcium signaling and phospho-antigen measurements reveal functional proximal TCR activation in lymphocytes from septic shock patients

Authors: Charles de Roquetaillade, Khalil Kandara, Morgane Gossez, Estelle Peronnet, Céline Monard, Martin Cour, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret and Fabienne Venet

Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons

Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. Clinically, the noble...

Authors: Nina C. Weber and Benedikt Preckel

Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model

Improvement of single site cannulation for extracorporeal membrane oxygenation (ECMO) therapy is pivotal for reduction of patient morbidity and mortality in respiratory failure. To further improve the cardiopu...

Authors: Ruslan Natanov, Abdurasul Khalikov, Faikah Gueler, Ulrich Maus, Erin C. Boyle, Axel Haverich, Christian Kühn and Nodir Madrahimov

Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?

Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent bi...

Authors: Mathun Kuganesan, Kavitej Samra, Eloise Evans, Mervyn Singer and Alex Dyson

Ethical considerations about artificial intelligence for prognostication in intensive care

Prognosticating the course of diseases to inform decision-making is a key component of intensive care medicine. For several applications in medicine, new methods from the field of artificial intelligence (AI) ...

Authors: Michael Beil, Ingo Proft, Daniel van Heerden, Sigal Sviri and Peter Vernon van Heerden

Report of the first AKI Round Table meeting: an initiative of the ESICM AKI Section

Critical Care Nephrology is an emerging sub-specialty of Critical Care. Despite increasing awareness about the serious impact of acute kidney injury (AKI) and renal replacement therapy (RRT), important knowled...

Authors: M. Ostermann, A. Schneider, T. Rimmele, I. Bobek, M. van Dam, M. Darmon, L. Forni, O. Joannes-Boyau, M. Joannidis, M. Legrand, J. Prowle, A. Zarbock and E. Hoste

Methane and Inflammation - A Review (Fight Fire with Fire)

Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally co...

Authors: Marietta Zita Poles, László Juhász and Mihály Boros

Moderately prolonged permissive hypotension results in reversible metabolic perturbation evaluated by intracerebral microdialysis - an experimental animal study

Damage control resuscitation (DCR) and damage control surgery (DCS) is the main strategy in patients with uncontrollable hemorrhagic shock. One aspect of DCR is permissive hypotension. However, the duration of...

Authors: Rasmus Peter Jakobsen, Troels Halfeld Nielsen, Simon Mølstrøm, Carl-Henrik Nordström, Asger Granfeldt and Palle Toft

Correction to: Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model

Please note that four authors (Logan Banadyga, Alixandra Albietz, Brad Pickering, and Gary Wong) have been erroneously omitted from the author list in the published original article [1].

Authors: Guillaume Poliquin, Duane Funk, Shane Jones, Kaylie Tran, Charlene Ranadheera, Mable Hagan, Kevin Tierney, Allen Grolla, Amrinder Dhaliwal, Alexander Bello, Anders Leung, Cory Nakamura, Darwyn Kobasa, Darryl Falzarano, Lauren Garnett, Hugues Fausther Bovendo…

Esmolol for cardioprotection during resuscitation with adrenaline in an ischaemic porcine cardiac arrest model

The effectiveness of adrenaline during resuscitation continues to be debated despite being recommended in international guidelines. There is evidence that the β-adrenergic receptor (AR) effects of adrenaline a...

Authors: Hilde Karlsen, Harald Arne Bergan, Per Steinar Halvorsen, Kjetil Sunde, Eirik Qvigstad, Geir Øystein Andersen, Jan Frederik Bugge and Theresa Mariero Olasveengen

Bench to bedside review: therapeutic modulation of nitric oxide in sepsis—an update

Nitric oxide is a signalling molecule with an extensive range of functions in both health and disease. Discovered in the 1980s through work that earned the Nobel prize, nitric oxide is an essential factor in r...

Authors: Simon Lambden

Needle-free connectors catheter-related bloodstream infections: a prospective randomized controlled trial

In the critically ill, catheter-related bloodstream infection can result from bacterial contamination of infusion hubs of intravascular catheters. Needle-free connectors (NFC) have been suggested to reduce the...

Authors: Michael Koeppen, Franziska Weinert, Sabrina Oehlschlaeger, Andreas Koerner, Peter Rosenberger and Helene Anna Haeberle

Combination of cardiac and thoracic pump theories in rodent cardiopulmonary resuscitation: a new method of three-side chest compression

High-quality cardiopulmonary resuscitation (HQ-CPR) is of paramount importance to improve neurological outcomes of cardiac arrest (CA). The purpose of this study was to evaluate chest compression methods by co...

Authors: Yu Okuma, Koichiro Shinozaki, Tsukasa Yagi, Kota Saeki, Tai Yin, Junhwan Kim and Lance B. Becker

Mechanical power at a glance: a simple surrogate for volume-controlled ventilation

Mechanical power is a summary variable including all the components which can possibly cause VILI (pressures, volume, flow, respiratory rate). Since the complexity of its mathematical computation is one of the...

Authors: Lorenzo Giosa, Mattia Busana, Iacopo Pasticci, Matteo Bonifazi, Matteo Maria Macrì, Federica Romitti, Francesco Vassalli, Davide Chiumello, Michael Quintel, J. J. Marini and Luciano Gattinoni

Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury

An on-going debate exists as to whether partial ventilatory support is lung protective in an acute phase of ARDS. So far, the effects of different respiratory efforts on the development of ventilator-associate...

Authors: Dietrich Henzler, Alf Schmidt, Zhaolin Xu, Nada Ismaiel, Haibo Zhang, Arthur S. Slutsky and Paolo Pelosi

Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury

Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal, physiological variation in aeration and lung density in experimental lung injury. The ability of dCT to predict whole-lung values ...

Authors: John N. Cronin, João Batista Borges, Douglas C. Crockett, Andrew D. Farmery, Göran Hedenstierna, Anders Larsson, Minh C. Tran, Luigi Camporota and Federico Formenti

Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

Advanced age is associated with increased mortality in acute respiratory distress syndrome (ARDS) patients. Preclinical studies suggest that the host response to an injurious challenge is age-dependent. In ARD...

Authors: Laura R. A. Schouten, Lieuwe D. J. Bos, A. Serpa Neto, Lonneke A. van Vught, Maryse A. Wiewel, Arie J. Hoogendijk, Marc J. M. Bonten, Olaf L. Cremer, Janneke Horn, Tom van der Poll, Marcus J. Schultz and Roelie M. Wösten-van Asperen

The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study

Septic cardiomyopathy (SCM) is common in sepsis and associated with increased morbidity and mortality. Left ventricular global longitudinal strain (LV GLS), measured by speckle tracking echocardiography, allow...

Authors: Meghan M. Cirulis, Sarah J. Beesley, Emily L. Wilson, Chris Stubben, Troy D. Olsen, Eliotte L. Hirshberg, Lane M. Smith, Michael J. Lanspa, Theodore P. Abraham, Colin K. Grissom, Matthew T. Rondina and Samuel M. Brown

ESICM LIVES 2019

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Respiratory and metabolic acidosis correction with the ADVanced Organ Support system

The lung, the kidney, and the liver are major regulators of acid-base balance. Acidosis due to the dysfunction of one or more organs can increase mortality, especially in critically ill patients. Supporting co...

Authors: Aritz Perez Ruiz de Garibay, John A. Kellum, Johannes Honigschnabel and Bernhard Kreymann