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  1. Content type: Research

    In prolonged non-obese critically ill patients, preservation of adipose tissue is prioritized over that of the skeletal muscle and coincides with increased adipogenesis. However, we recently demonstrated that ...

    Authors: Chloë Goossens, Sarah Vander Perre, Greet Van den Berghe and Lies Langouche

    Citation: Intensive Care Medicine Experimental 2017 5:16

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  2. Content type: Research

    Controlled mechanical ventilation (CMV) is associated with diaphragm dysfunction. Dysfunction results from muscle atrophy and injury of diaphragm muscle fibers. Enhanced proteolysis and reduced protein synthes...

    Authors: Xiaoping Zhu, Hieronymus W. H. van Hees, Leo Heunks, Feifei Wang, Lei Shao, Jiaru Huang, Lei Shi and Shaolin Ma

    Citation: Intensive Care Medicine Experimental 2017 5:14

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  3. Content type: Research

    Mesenchymal stem cells (MSCs) might act as fine-tuners of inflammation during acute lung injury. We assessed the effects of adoptive transfer of MSCs in acid aspiration acute lung injury and explored the role ...

    Authors: Tommaso Mauri, Vanessa Zambelli, Claudia Cappuzzello, Giacomo Bellani, Erica Dander, Marina Sironi, Vittoria Castiglioni, Andrea Doni, Alberto Mantovani, Andrea Biondi, Cecilia Garlanda, Giovanna D’amico and Antonio Pesenti

    Citation: Intensive Care Medicine Experimental 2017 5:13

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  4. Content type: Research

    Low hemoglobin concentration (Hb) and low mean arterial blood pressure (MAP) impact outcomes in critically ill patients. We utilized an experimental model of “normotensive” vs. “hypotensive” acute hemodilution...

    Authors: Tiffanie Kei, Nikhil Mistry, Albert K. Y. Tsui, Elaine Liu, Stephen Rogers, Allan Doctor, David F. Wilson, Jean-Francois Desjardins, Kim Connelly, C. David Mazer and Gregory M. T. Hare

    Citation: Intensive Care Medicine Experimental 2017 5:12

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  5. Content type: Research

    Increasing intra-abdominal volume (IAV) can lead to intra-abdominal hypertension (IAH) or abdominal compartment syndrome. Both are associated with raised morbidity and mortality. IAH can increase airway pressu...

    Authors: Adrian Regli, Bart Leon De Keulenaer, Bhajan Singh, Lisen Emma Hockings, Bill Noffsinger and Peter Vernon van Heerden

    Citation: Intensive Care Medicine Experimental 2017 5:11

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  6. Content type: Research

    The purposes of this study are to examine if the human glucocorticoid receptor (hGR) isoform-α mRNA and hGR protein expressions are deficient in the acute phase of sepsis (S) compared to systemic inflammatory ...

    Authors: Konstantinos Vardas, Stavroula Ilia, Amalia Sertedaki, Evangelia Charmandari, Efrossini Briassouli, Dimitris Goukos, Kleovoulos Apostolou, Katerina Psarra, Efthimia Botoula, Stylianos Tsagarakis, Eleni Magira, Christina Routsi, Constantine A. Stratakis, Serafim Nanas and George Briassoulis

    Citation: Intensive Care Medicine Experimental 2017 5:10

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  7. Content type: Letter to the Editor

    Intensive care units provide specialised care for critically ill patients around the clock. However, intensive care unit patients have disrupted circadian rhythms. Furthermore, disrupted circadian rhythms are ...

    Authors: Hannah J. Durrington, Richard Clark, Ruari Greer, Franck P. Martial, John Blaikley, Paul Dark, Robert J. Lucas and David W. Ray

    Citation: Intensive Care Medicine Experimental 2017 5:9

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  8. Content type: Review

    It has been shown that mechanical ventilation in patients with, or at high-risk for, the development of acute respiratory distress syndrome (ARDS) can be a double-edged sword. If the mechanical breath is impro...

    Authors: Gary F. Nieman, Joshua Satalin, Penny Andrews, Hani Aiash, Nader M. Habashi and Louis A. Gatto

    Citation: Intensive Care Medicine Experimental 2017 5:8

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  9. Content type: Research

    The initial phase of sepsis is characterized by hyperinflammation. Levels of thrombospondin-1 (TSP-1) rise rapidly during acute inflammation. The purpose of this clinical study was to study the association bet...

    Authors: Ruben J. van der Wekken, Hans Kemperman, Mark Roest and Dylan W. de Lange

    Citation: Intensive Care Medicine Experimental 2017 5:7

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  10. Content type: Research

    Fluid resuscitation is a crucial therapy for sepsis, and the use of balanced fluids and/or isotonic albumin may improve patient survival. We have previously demonstrated that resuscitation with normal saline r...

    Authors: Amanda L. Patrick, Peter M. Grin, Nicole Kraus, Michelle Gold, Matthew Berardocco, Patricia C. Liaw and Alison E. Fox-Robichaud

    Citation: Intensive Care Medicine Experimental 2017 5:5

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  11. Content type: Research

    A key feature of sepsis is systemic inflammatory activation that could be counteracted by steroids. In this experimental model of systemic inflammation, we sought to investigate whether septic neutrophil activ...

    Authors: E. Söderberg, M. Eriksson, A. Larsson and M. Lipcsey

    Citation: Intensive Care Medicine Experimental 2017 5:4

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  12. Content type: Research

    Critically ill patients develop atrophic muscle failure, which increases morbidity and mortality. Interleukin-1β (IL-1β) is activated early in sepsis. Whether IL-1β acts directly on muscle cells and whether it...

    Authors: Nora Huang, Melanie Kny, Fabian Riediger, Katharina Busch, Sibylle Schmidt, Friedrich C. Luft, Hortense Slevogt and Jens Fielitz

    Citation: Intensive Care Medicine Experimental 2017 5:3

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  13. Content type: Letter to the Editor

    Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis...

    Authors: Benjamin Holst, Tamas Szakmany, Anne-Catherine Raby, Vincent Hamlyn, Kimberley Durno, Judith E. Hall and Mario O. Labéta

    Citation: Intensive Care Medicine Experimental 2017 5:2

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  14. Content type: Research

    Intravenous (IV) immunoglobulin (Ig) treatment is known to alleviate behavioral deficits and increase survival in the experimentally induced model of sepsis. To delineate the mechanisms by which IVIg treatment...

    Authors: Figen Esen, Gunseli Orhun, Perihan Ergin Ozcan, Evren Senturk, Melike Kucukerden, Murat Giris, Ugur Akcan, Canan Ugur Yilmaz, Nurcan Orhan, Nadir Arican, Mehmet Kaya, Sema Bilgic Gazioglu and Erdem Tuzun

    Citation: Intensive Care Medicine Experimental 2017 5:1

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  15. Content type: Letter to the Editor

    In this commentary, the authors discuss two possible approaches in experimental studies. The first approach is to replicate an experimentation in order to confirm or not previously published results. The secon...

    Authors: Julien Demiselle, Frauke Tillmans, Andreas Koch, Peter Radermacher and Pierre Asfar

    Citation: Intensive Care Medicine Experimental 2016 4:39

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  16. Content type: Review

    Recent research has identified an increased rate of mortality associated with fluid bolus therapy for severe sepsis and septic shock, but the mechanisms are still not well understood. Fluid resuscitation thera...

    Authors: Nchafatso G. Obonyo, Jonathon P. Fanning, Angela S. Y. Ng, Leticia P. Pimenta, Kiran Shekar, David G. Platts, Kathryn Maitland and John F. Fraser

    Citation: Intensive Care Medicine Experimental 2016 4:38

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  17. Content type: Research

    Life-threatening diseases of critically ill patients are known to derange microcirculation. Automatic analysis of microcirculation would provide a bedside diagnostic tool for microcirculatory disorders and all...

    Authors: Philip-Helge Arnemann, Michael Hessler, Tim Kampmeier, Andrea Morelli, Hugo Karel Van Aken, Martin Westphal, Sebastian Rehberg and Christian Ertmer

    Citation: Intensive Care Medicine Experimental 2016 4:37

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  18. Content type: Research

    Histamine assumes an important role as a major mediator in various pathologic disorders associated with inflammation and immune reactions. However, the involvement of histamine in the pathological conditions a...

    Authors: Mizuki Hattori, Mitsuaki Yamazaki, Wakana Ohashi, Satoshi Tanaka, Kohshi Hattori, Kenichiro Todoroki, Toshio Fujimori, Hiroshi Ohtsu, Naoyuki Matsuda and Yuichi Hattori

    Citation: Intensive Care Medicine Experimental 2016 4:36

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  19. Content type: Research

    In patients with emphysema, invasive mechanical ventilation settings should be adjusted to minimize hyperinflation while reducing respiratory effort and providing adequate gas exchange. We evaluated the impact...

    Authors: Gisele de A. Padilha, Lucas F. B. Horta, Lillian Moraes, Cassia L. Braga, Milena V. Oliveira, Cíntia L. Santos, Isalira P. Ramos, Marcelo M. Morales, Vera Luiza Capelozzi, Regina C. S. Goldenberg, Marcelo Gama de Abreu, Paolo Pelosi, Pedro L. Silva and Patricia R. M. Rocco

    Citation: Intensive Care Medicine Experimental 2016 4:35

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  20. Content type: Research

    Hypoxemia may compromise cell metabolism and organ function. Supplemental oxygen (O2) at high concentrations may prove ineffective, and issues relating to hyperoxia, barotrauma, mechanical ventilation, and extrac...

    Authors: Elisa Damiani, Alex Dyson, Lucia Zacchetti, Abele Donati and Mervyn Singer

    Citation: Intensive Care Medicine Experimental 2016 4:34

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  21. Content type: Research

    Elevated plasma levels of heparin-binding protein (HBP) are associated with risk of organ dysfunction and mortality in sepsis, but little is known about causality and mechanisms of action of HBP. The objective...

    Authors: Peter Bentzer, Jane Fisher, HyeJin Julia Kong, Mattias Mörgelin, John H. Boyd, Keith R. Walley, James A. Russell and Adam Linder

    Citation: Intensive Care Medicine Experimental 2016 4:33

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    The Erratum to this article has been published in Intensive Care Medicine Experimental 2017 5:6

  22. Content type: Meeting abstracts

    Authors: L. Bos, L. Schouten, L. van Vught, M. Wiewel, D. Ong, O. Cremer, A. Artigas, I. Martin-Loeches, A. Hoogendijk, T. van der Poll, J. Horn, N. Juffermans, M. Schultz, N. de Prost, T. Pham, G. Carteaux…

    Citation: Intensive Care Medicine Experimental 2016 4(Suppl 1):98

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    This article is part of a Supplement: Volume 4 Supplement 1

    The Correction to this article has been published in Intensive Care Medicine Experimental 2018 6:48

  23. Content type: Research

    Target temperature management is the single most effective intervention and the gold standard in post-resuscitation care today. However, cooling the whole body below 33–34 °C can cause severe complications. Th...

    Authors: Mohammad Fazel Bakhsheshi, Yong Wang, Lynn Keenliside and Ting-Yim Lee

    Citation: Intensive Care Medicine Experimental 2016 4:32

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  24. Content type: Research

    The object of this study is to explore whether the plasmadiafiltration (PDF) is more effective in improving the intestinal mucosal barrier function by removing more key large molecular inflammatory mediators a...

    Authors: Ming Xin Li, Jun Feng Liu, Jian Da Lu, Ying Zhu, Ding Wei Kuang, Jian Bing Xiang, Peng Sun, Wei Wang, Jun Xue, Yong Gu and Chuan Ming Hao

    Citation: Intensive Care Medicine Experimental 2016 4:31

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  25. Content type: Meeting abstracts

    Authors: S. Sivakumar, F. S. Taccone, K. A. Desai, C. Lazaridis, M. Skarzynski, M. Sekhon, W. Henderson, D. Griesdale, L. Chapple, A. Deane, L. Williams, R. Strickland, K. Lange, D. Heyland, M. Chapman, M. J. Rowland…

    Citation: Intensive Care Medicine Experimental 2016 4(Suppl 1):30

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    This article is part of a Supplement: Volume 4 Supplement 1

  26. Content type: Meeting abstracts

    Authors: T. Velasquez, G. Mackey, J. Lusk, U. G. Kyle, T. Fontenot, P. Marshall, L. S. Shekerdemian, J. A. Coss-Bu, A. Nishigaki, T. Yatabe, T. Tamura, K. Yamashita, M. Yokoyama, J. C. Ruiz-Rodriguez, B. Encina, R. Belmonte…

    Citation: Intensive Care Medicine Experimental 2016 4(Suppl 1):28

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    This article is part of a Supplement: Volume 4 Supplement 1

  27. Content type: Research

    Modulation of inflammation and oxidative stress appears to limit sepsis-induced damage in experimental models. The kidney is one of the most sensitive organs to injury during septic shock. In this study, we ev...

    Authors: Bulent Ergin, Philippe Guerci, Lara Zafrani, Frank Nocken, Asli Kandil, Ebru Gurel-Gurevin, Cihan Demirci-Tansel and Can Ince

    Citation: Intensive Care Medicine Experimental 2016 4:29

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  28. Content type: Research

    We have shown in acute lung injury patients that lung elastance can be determined by a positive end-expiratory pressure (PEEP) step procedure and proposed that this is explained by the spring-out force of the ...

    Authors: Per Persson, Stefan Lundin and Ola Stenqvist

    Citation: Intensive Care Medicine Experimental 2016 4:26

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  29. Content type: Research

    It is not yet clear whether hemofiltration can reduce blood cytokine levels sufficiently to benefit patients who suffer prolonged cardiac arrest (CA) treated with cardiopulmonary bypass (CPB). We sought to ass...

    Authors: Koichiro Shinozaki, Joshua W. Lampe, Junhwan Kim, Tai Yin, Tong Da, Shigeto Oda, Hiroyuki Hirasawa and Lance B. Becker

    Citation: Intensive Care Medicine Experimental 2016 4:25

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  30. Content type: Research

    The development of lactic acidemia (LA) in septic shock (SS) is associated with an ominous prognosis. We previously showed that the mechanism of LA in SS may relate to impaired hepatic uptake of lactate, but t...

    Authors: Steven Mink, Subir K. Roy Chowdhury, Jose Gotes, Zhao-Qin Cheng, Krika Kasian and Paul Fernyhough

    Citation: Intensive Care Medicine Experimental 2016 4:24

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  31. Content type: Research

    The endothelium is a potentially valuable target for sepsis therapy. We have previously studied an extracorporeal endothelial cell therapy system, called the endothelial bioreactor (EBR), which prolonged the s...

    Authors: Shuai Ma, Yuli Lin, Bo Deng, Yin Zheng, Chuanming Hao, Rui He and Feng Ding

    Citation: Intensive Care Medicine Experimental 2016 4:23

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  32. Content type: Research

    The cecal ligation and puncture (CLP) model, a gold standard in sepsis research, is associated with an important variability in mortality. While the number of punctures and needle size is well described in CLP...

    Authors: Stéphanie Ruiz, Fanny Vardon-Bounes, Virginie Merlet-Dupuy, Jean-Marie Conil, Marie Buléon, Olivier Fourcade, Ivan Tack and Vincent Minville

    Citation: Intensive Care Medicine Experimental 2016 4:22

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  33. Content type: Research

    Critical illness causes a shift away from mitochondrial metabolism towards a greater dependence on glycolysis. This metabolic shift is thought to be associated with lactic acidosis, organ dysfunction and poor ...

    Authors: Marek Nalos, Grant Parnell, Robert Robergs, David Booth, Anthony S. McLean and Benjamin M. Tang

    Citation: Intensive Care Medicine Experimental 2016 4:21

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  34. Content type: Research

    Stimulation of the vagus nerve has modulating, anti-inflammatory effects on the cellular immune response in the blood and the spleen, stabilizing brain function. Here, we aimed to investigate its potential eff...

    Authors: Hanna Schweighöfer, Christoph Rummel, Joachim Roth and Bernhard Rosengarten

    Citation: Intensive Care Medicine Experimental 2016 4:19

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  35. Content type: Erratum

    Authors: Benedikt L. Nußbaum, Oscar McCook, Clair Hartmann, José Matallo, Martin Wepler, Elena Antonucci, Miriam Kalbitz, Markus Huber-Lang, Michael Georgieff, Enrico Calzia, Peter Radermacher and Sebastian Hafner

    Citation: Intensive Care Medicine Experimental 2016 4:18

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    The original article was published in Intensive Care Medicine Experimental 2016 4:14

  36. Content type: Research

    Traumatic hemorrhagic shock (THS) is a leading cause of preventable death following severe traumatic injury. Resuscitation of THS is typically targeted at blood pressure, but the effects of such a strategy on ...

    Authors: Sam D. Hutchings, David N. Naumann, Sarah Watts, Callie Wilson, Clare Burton, Julia Wendon and Emrys Kirkman

    Citation: Intensive Care Medicine Experimental 2016 4:17

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  37. Content type: Commentary

    It was recently shown that acute respiratory distress syndrome (ARDS) mortality has not been reduced in over 15 years and remains ~40 %, even with protective low tidal volume (LVt) ventilation. Thus, there is ...

    Authors: Gary F. Nieman, Joshua Satalin, Penny Andrews, Nader M. Habashi and Louis A. Gatto

    Citation: Intensive Care Medicine Experimental 2016 4:16

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  38. Content type: Erratum

    Authors: R. Fernández Fernández, M. Herreros Gonzalo, L. Serrano Fernández, L. Camacho Peinado, N. Cruza Leganés, M. Á. Taberna Izquierdo, F. Alba García and F. Árbol Linde

    Citation: Intensive Care Medicine Experimental 2016 4:15

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    The original article was published in Intensive Care Medicine Experimental 2015 3:A706

  39. Content type: Research

    Reversible, depressed cardiac function is frequently encountered during septic shock and commonly called septic cardiomyopathy. Previous studies demonstrated reduced ejection fraction and left ventricular dila...

    Authors: Benedikt L. Nußbaum, Oscar McCook, Clair Hartmann, José Matallo, Martin Wepler, Elena Antonucci, Miriam Kalbitz, Markus Huber-Lang, Michael Georgieff, Enrico Calzia, Peter Radermacher and Sebastian Hafner

    Citation: Intensive Care Medicine Experimental 2016 4:14

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    The Erratum to this article has been published in Intensive Care Medicine Experimental 2016 4:18

  40. Content type: Research

    The pressure-recording analytical method is a new semi-invasive method for cardiac output measurement (PRAM). There are no studies comparing this technique with femoral artery thermodilution (FATD) in an infan...

    Authors: Javier Urbano, Jorge López, Rafael González, Sarah N. Fernández, María José Solana, Blanca Toledo, Ángel Carrillo and Jesús López-Herce

    Citation: Intensive Care Medicine Experimental 2016 4:13

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  41. Content type: Research

    The recent discovery of cell cycle arrest biomarkers, tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7), has led to a newly available clinical test for a...

    Authors: Zhi-Yong Peng, Feihu Zhou and John A. Kellum

    Citation: Intensive Care Medicine Experimental 2016 4:12

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  42. Content type: Review

    Airway pressure release ventilation (APRV) was first described in 1987 and defined as continuous positive airway pressure (CPAP) with a brief release while allowing the patient to spontaneously breathe through...

    Authors: Sumeet V. Jain, Michaela Kollisch-Singule, Benjamin Sadowitz, Luke Dombert, Josh Satalin, Penny Andrews, Louis A. Gatto, Gary F. Nieman and Nader M. Habashi

    Citation: Intensive Care Medicine Experimental 2016 4:11

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  43. Content type: Research

    Reduced motor and sensory nerve amplitudes in critical illness polyneuropathy (CIP) are characteristic features described in electrophysiological studies and due to dysfunction of voltage-gated sodium channels...

    Authors: Susanne Koch, Jeffrey Bierbrauer, Kurt Haas, Simone Wolter, Julian Grosskreutz, Friedrich C. Luft, Claudia D. Spies, Jens Fielitz and Steffen Weber-Carstens

    Citation: Intensive Care Medicine Experimental 2016 4:10

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  44. Content type: Research

    Serum biomarkers may play a role in prognostication after cardiac arrest. This study was designed to assess the feasibility of using two-dimensional gel electrophoresis (2D-GE) coupled with mass spectrometry (...

    Authors: J. Gordon Boyd, Laura J. Smithson, Daniel Howes, John Muscedere and Michael D. Kawaja

    Citation: Intensive Care Medicine Experimental 2016 4:9

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  45. Content type: Research

    Hypercapnia, with its associated acidosis (HCA), is a consequence of respiratory failure and is also seen in critically ill patients managed with conventional “protective” ventilation strategies. Nuclear facto...

    Authors: Shahd Horie, Bilal Ansari, Claire Masterson, James Devaney, Michael Scully, Daniel O’Toole and John G. Laffey

    Citation: Intensive Care Medicine Experimental 2016 4:8

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  46. Content type: Research

    Echocardiography is a key investigation in the management of patients on extracorporeal membrane oxygenation (ECMO). However, echocardiographic images are often non-diagnostic in this patient population. Contr...

    Authors: David G. Platts, Charles McDonald, Kiran Shekar, Darryl J. Burstow, Daniel Mullany, Marc Ziegenfuss, Sara Diab and John F. Fraser

    Citation: Intensive Care Medicine Experimental 2016 4:7

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  47. Content type: Research

    Early use of fresh frozen plasma (FFP) in haemorrhagic shock is associated with improved outcome. This effect may partly be due to protection of the endothelial glycocalyx and/or secondary to a superior effica...

    Authors: Axel Nelson, Svajunas Statkevicius, Ulf Schött, Pär I. Johansson and Peter Bentzer

    Citation: Intensive Care Medicine Experimental 2016 4:6

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  48. Content type: Research

    The nature of the inflammatory response underscoring the pathophysiology of sepsis has been extensively studied. We hypothesized that different cell functions would be differentially regulated in a patient wit...

    Authors: Sidnéia S. Santos, Amanda M. Carmo, Milena K. C. Brunialti, Flavia R. Machado, Luciano C. Azevedo, Murillo Assunção, Sílvia C. Trevelin, Fernando Q. Cunha and Reinaldo Salomao

    Citation: Intensive Care Medicine Experimental 2016 4:5

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