Articles

In vitro characterization of PrismaLung+: a novel ECCO₂R device

Invasive mechanical ventilation is lifesaving in the setting of severe acute respiratory failure but can cause ventilation-induced lung injury. Advances in extracorporeal CO₂ removal (ECCO₂R) technologies may fac...

Authors: Ingeborg Hospach, Jacques Goldstein, Kai Harenski, John G. Laffey, Dominique Pouchoulin, Manuela Raible, Stefanie Votteler and Markus Storr

Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke

Several therapeutic strategies to rescue the brain from ischemic injury have improved outcomes after stroke; however, there is no treatment as yet for reperfusion injury, the secondary damage caused by necessa...

Authors: Bruna Pescador Mendonça, Juliano Dos Santos Cardoso, Monique Michels, Ana Carolina Vieira, Diogo Wendhausen, Andressa Manfredini, Mervyn Singer, Felipe Dal-Pizzol and Alex Dyson

New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma

Patients often develop infectious complications after severe trauma. No biomarkers exist that enable early identification of patients who are at risk. Neutrophils are important immune cells that combat these i...

Authors: Lillian Hesselink, Roy Spijkerman, Emma de Fraiture, Suzanne Bongers, Karlijn J. P. Van Wessem, Nienke Vrisekoop, Leo Koenderman, Luke P. H. Leenen and Falco Hietbrink

Update of the organoprotective properties of xenon and argon: from bench to beside

The growth of the elderly population has led to an increase in patients with myocardial infarction and stroke (Wajngarten and Silva, Eur Cardiol 14: 111–115, 2019). Patients receiving treatment for ST-segment-...

Authors: Roehl Anna, Rossaint Rolf and Coburn Mark

Real-time effects of PEEP and tidal volume on regional ventilation and perfusion in experimental lung injury

Real-time bedside information on regional ventilation and perfusion during mechanical ventilation (MV) may help to elucidate the physiological and pathophysiological effects of MV settings in healthy and injur...

Authors: João Batista Borges, John N. Cronin, Douglas C. Crockett, Göran Hedenstierna, Anders Larsson and Federico Formenti

Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury

Sepsis, a dysregulated host response to infection with results in organ dysfunction, has been a major challenge to the development of effective therapeutics. Sepsis-associated acute kidney injury (S-AKI) resul...

Authors: Xiaoyan Wen, Shengnan Li, Alicia Frank, Xiukai Chen, David Emlet, Neil A. Hukriede and John A. Kellum

Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism

Human mesenchymal stem/stromal cells (hMSCs) represent a promising therapeutic strategy for ventilator-induced lung injury (VILI) and acute respiratory distress syndrome. Translational challenges include resto...

Authors: Shahd Horie, Sean Gaynard, Mary Murphy, Frank Barry, Michael Scully, Daniel O’Toole and John G. Laffey

Checkpoint inhibitor therapy in preclinical sepsis models: a systematic review and meta-analysis

Animal studies reporting immune checkpoint inhibitors (CPIs) improved host defense and survival during bacterial sepsis provided one basis for phase I CPI sepsis trials. We performed a systematic review and me...

Authors: Lindsay M. Busch, Junfeng Sun, Xizhong Cui, Peter Q. Eichacker and Parizad Torabi-Parizi

In vitro comparison between inspiration synchronized and continuous vibrating mesh nebulizer during trans-nasal aerosol delivery

Compared to continuous vibrating mesh nebulizer (VMN), inspiration synchronized VMN has shown increased inhaled dose during noninvasive ventilation; however, its use during aerosol delivery via high-flow nasal...

Authors: Jie Li, Wei Wu and James B. Fink

Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness

Hydrogen sulfide (H₂S) has long been known as a toxic environmental hazard. Discovery of physiological roles of H₂S as a neurotransmitter by Kimura and colleagues triggered an intensive research in the biological...

Authors: Eizo Marutani and Fumito Ichinose

Correction to: A case of intracoronary and endovenous levosimendan as a rescue therapy for refractory cardiac arrest

After publication of this supplement [1], it was brought to our attention that the author ‘L. Vegnuti’ has been erroneously omitted from the author list of the following abstract.

Authors: B. Ferro, R. Tofani, L. Vegnuti, G. Borelli, L. Gargani and P. Roncucci

Meta-analysis of targeted temperature management in animal models of cardiac arrest

Targeted temperature management (TTM) of 32 to 34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 indicated benefit on survival and neurological outcome. In ...

Authors: Hilmer Olai, Gustav Thornéus, Hannah Watson, Malcolm Macleod, Jonathan Rhodes, Hans Friberg, Niklas Nielsen, Tobias Cronberg and Tomas Deierborg

Carbon monoxide in intensive care medicine—time to start the therapeutic application?!

Carbon monoxide (CO) is not only known as a toxic gas due to its characteristics as an odorless molecule and its rapid binding to haem-containing molecules, thus inhibiting the respiratory chain in cells resul...

Authors: Ulrich Goebel and Jakob Wollborn

Aortic volume determines global end-diastolic volume measured by transpulmonary thermodilution

Global end-diastolic volume (GEDV) measured by transpulmonary thermodilution is regarded as indicator of cardiac preload. A bolus of cold saline injected in a central vein travels through the heart and lung, b...

Authors: Aleksej Akohov, Christoph Barner, Steffen Grimmer, Roland CE Francis and Stefan Wolf

Intracellular calcium signaling and phospho-antigen measurements reveal functional proximal TCR activation in lymphocytes from septic shock patients

Authors: Charles de Roquetaillade, Khalil Kandara, Morgane Gossez, Estelle Peronnet, Céline Monard, Martin Cour, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret and Fabienne Venet

Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons

Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. Clinically, the noble...

Authors: Nina C. Weber and Benedikt Preckel

Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model

Improvement of single site cannulation for extracorporeal membrane oxygenation (ECMO) therapy is pivotal for reduction of patient morbidity and mortality in respiratory failure. To further improve the cardiopu...

Authors: Ruslan Natanov, Abdurasul Khalikov, Faikah Gueler, Ulrich Maus, Erin C. Boyle, Axel Haverich, Christian Kühn and Nodir Madrahimov

Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?

Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent bi...

Authors: Mathun Kuganesan, Kavitej Samra, Eloise Evans, Mervyn Singer and Alex Dyson

Ethical considerations about artificial intelligence for prognostication in intensive care

Prognosticating the course of diseases to inform decision-making is a key component of intensive care medicine. For several applications in medicine, new methods from the field of artificial intelligence (AI) ...

Authors: Michael Beil, Ingo Proft, Daniel van Heerden, Sigal Sviri and Peter Vernon van Heerden

Report of the first AKI Round Table meeting: an initiative of the ESICM AKI Section

Critical Care Nephrology is an emerging sub-specialty of Critical Care. Despite increasing awareness about the serious impact of acute kidney injury (AKI) and renal replacement therapy (RRT), important knowled...

Authors: M. Ostermann, A. Schneider, T. Rimmele, I. Bobek, M. van Dam, M. Darmon, L. Forni, O. Joannes-Boyau, M. Joannidis, M. Legrand, J. Prowle, A. Zarbock and E. Hoste

Methane and Inflammation - A Review (Fight Fire with Fire)

Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally co...

Authors: Marietta Zita Poles, László Juhász and Mihály Boros

Moderately prolonged permissive hypotension results in reversible metabolic perturbation evaluated by intracerebral microdialysis - an experimental animal study

Damage control resuscitation (DCR) and damage control surgery (DCS) is the main strategy in patients with uncontrollable hemorrhagic shock. One aspect of DCR is permissive hypotension. However, the duration of...

Authors: Rasmus Peter Jakobsen, Troels Halfeld Nielsen, Simon Mølstrøm, Carl-Henrik Nordström, Asger Granfeldt and Palle Toft

Correction to: Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model

Please note that four authors (Logan Banadyga, Alixandra Albietz, Brad Pickering, and Gary Wong) have been erroneously omitted from the author list in the published original article [1].

Authors: Guillaume Poliquin, Duane Funk, Shane Jones, Kaylie Tran, Charlene Ranadheera, Mable Hagan, Kevin Tierney, Allen Grolla, Amrinder Dhaliwal, Alexander Bello, Anders Leung, Cory Nakamura, Darwyn Kobasa, Darryl Falzarano, Lauren Garnett, Hugues Fausther Bovendo…

Esmolol for cardioprotection during resuscitation with adrenaline in an ischaemic porcine cardiac arrest model

The effectiveness of adrenaline during resuscitation continues to be debated despite being recommended in international guidelines. There is evidence that the β-adrenergic receptor (AR) effects of adrenaline a...

Authors: Hilde Karlsen, Harald Arne Bergan, Per Steinar Halvorsen, Kjetil Sunde, Eirik Qvigstad, Geir Øystein Andersen, Jan Frederik Bugge and Theresa Mariero Olasveengen

Bench to bedside review: therapeutic modulation of nitric oxide in sepsis—an update

Nitric oxide is a signalling molecule with an extensive range of functions in both health and disease. Discovered in the 1980s through work that earned the Nobel prize, nitric oxide is an essential factor in r...

Authors: Simon Lambden

Needle-free connectors catheter-related bloodstream infections: a prospective randomized controlled trial

In the critically ill, catheter-related bloodstream infection can result from bacterial contamination of infusion hubs of intravascular catheters. Needle-free connectors (NFC) have been suggested to reduce the...

Authors: Michael Koeppen, Franziska Weinert, Sabrina Oehlschlaeger, Andreas Koerner, Peter Rosenberger and Helene Anna Haeberle

Combination of cardiac and thoracic pump theories in rodent cardiopulmonary resuscitation: a new method of three-side chest compression

High-quality cardiopulmonary resuscitation (HQ-CPR) is of paramount importance to improve neurological outcomes of cardiac arrest (CA). The purpose of this study was to evaluate chest compression methods by co...

Authors: Yu Okuma, Koichiro Shinozaki, Tsukasa Yagi, Kota Saeki, Tai Yin, Junhwan Kim and Lance B. Becker

Mechanical power at a glance: a simple surrogate for volume-controlled ventilation

Mechanical power is a summary variable including all the components which can possibly cause VILI (pressures, volume, flow, respiratory rate). Since the complexity of its mathematical computation is one of the...

Authors: Lorenzo Giosa, Mattia Busana, Iacopo Pasticci, Matteo Bonifazi, Matteo Maria Macrì, Federica Romitti, Francesco Vassalli, Davide Chiumello, Michael Quintel, J. J. Marini and Luciano Gattinoni

Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury

An on-going debate exists as to whether partial ventilatory support is lung protective in an acute phase of ARDS. So far, the effects of different respiratory efforts on the development of ventilator-associate...

Authors: Dietrich Henzler, Alf Schmidt, Zhaolin Xu, Nada Ismaiel, Haibo Zhang, Arthur S. Slutsky and Paolo Pelosi

Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury

Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal, physiological variation in aeration and lung density in experimental lung injury. The ability of dCT to predict whole-lung values ...

Authors: John N. Cronin, João Batista Borges, Douglas C. Crockett, Andrew D. Farmery, Göran Hedenstierna, Anders Larsson, Minh C. Tran, Luigi Camporota and Federico Formenti

Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

Advanced age is associated with increased mortality in acute respiratory distress syndrome (ARDS) patients. Preclinical studies suggest that the host response to an injurious challenge is age-dependent. In ARD...

Authors: Laura R. A. Schouten, Lieuwe D. J. Bos, A. Serpa Neto, Lonneke A. van Vught, Maryse A. Wiewel, Arie J. Hoogendijk, Marc J. M. Bonten, Olaf L. Cremer, Janneke Horn, Tom van der Poll, Marcus J. Schultz and Roelie M. Wösten-van Asperen

The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study

Septic cardiomyopathy (SCM) is common in sepsis and associated with increased morbidity and mortality. Left ventricular global longitudinal strain (LV GLS), measured by speckle tracking echocardiography, allow...

Authors: Meghan M. Cirulis, Sarah J. Beesley, Emily L. Wilson, Chris Stubben, Troy D. Olsen, Eliotte L. Hirshberg, Lane M. Smith, Michael J. Lanspa, Theodore P. Abraham, Colin K. Grissom, Matthew T. Rondina and Samuel M. Brown

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Respiratory and metabolic acidosis correction with the ADVanced Organ Support system

The lung, the kidney, and the liver are major regulators of acid-base balance. Acidosis due to the dysfunction of one or more organs can increase mortality, especially in critically ill patients. Supporting co...

Authors: Aritz Perez Ruiz de Garibay, John A. Kellum, Johannes Honigschnabel and Bernhard Kreymann

Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model

There are currently limited data for the use of specific antiviral therapies for the treatment of Ebola virus disease (EVD). While there is anecdotal evidence that supportive care may be effective, there is a ...

Authors: Guillaume Poliquin, Duane Funk, Shane Jones, Kaylie Tran, Charlene Ranadheera, Mable Hagan, Kevin Tierney, Allen Grolla, Amrinder Dhaliwal, Alexander Bello, Anders Leung, Cory Nakamura, Darwyn Kobasa, Darryl Falzarano, Lauren Garnett, Hugues Fausther Bovendo…

Peroxynitrite decomposition catalyst reduces vasopressin requirement in ovine MRSA sepsis

Sepsis is one of the most frequent causes of death in the intensive care unit. Host vascular hypo-responsiveness to vasopressors during septic shock is one of the challenging problems. This study tested the hy...

Authors: Osamu Fujiwara, Satoshi Fukuda, Ernesto Lopez, Yaping Zeng, Yosuke Niimi, Douglas S. DeWitt, David N. Herndon, Donald S. Prough and Perenlei Enkhbaatar

Determining rhythmicity and determinism of temperature curves in septic and non-septic critically ill patients through chronobiological and recurrence quantification analysis: a pilot study

A few studies have demonstrated that critically ill patients exhibit circadian deregulation and reduced complexity of different time series, such as temperature.

Authors: Vasilios E. Papaioannou, Eleni N. Sertaridou, Ioanna G. Chouvarda, George C. Kolios and Ioannis N. Pneumatikos

The impact of the systemic inflammatory response on hepatic bacterial elimination in experimental abdominal sepsis

Bacterial translocation from the gut has been suggested to induce a systemic inflammatory response syndrome (SIRS) and organ dysfunction. The liver has a pivotal role in eliminating circulating bacteria enteri...

Authors: Katja Hanslin, Jan Sjölin, Paul Skorup, Frida Wilske, Robert Frithiof, Anders Larsson, Markus Castegren, Eva Tano and Miklos Lipcsey

Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit

Extracorporeal membrane oxygenation (ECMO) is a life-saving modality used to manage cardiopulmonary failure refractory to conventional medical and surgical therapies. Despite advances in ECMO equipment, bleedi...

Authors: Katrina K. Ki, Margaret R. Passmore, Chris H. H. Chan, Maximilian V. Malfertheiner, Jonathon P. Fanning, Mahé Bouquet, Jonathan E. Millar, John F. Fraser and Jacky Y. Suen

Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients

Accurate measurement of pulmonary oxygenation is important for classification of disease severity and quantification of outcomes in clinical studies. Currently, tension-based methods such as P/F ratio are in w...

Authors: Emma M. Chang, Andrew Bretherick, Gordon B. Drummond and J Kenneth Baillie

Effect of landiolol on sex-related transcriptomic changes in the myocardium during sepsis

The aims of this study are to better understand phenotypic differences between male and female rats during sepsis, to characterise the contribution of the beta1-adrenergic blocker landiolol to septic cardiomyo...

Authors: Thi Thom Tran, Calypso Mathieu, Magali Torres, Béatrice Loriod, Linh Thuy Lê, Catherine Nguyen, Monique Bernard, Marc Leone and Nathalie Lalevée

Development of a model for anemia of inflammation that is relevant to critical care

Anemia of inflammation (AI) is common in critically ill patients. Although this syndrome negatively impacts the outcome of critical illness, understanding of its pathophysiology is limited. Also, new therapies...

Authors: Margit Boshuizen, Robin van Bruggen, Sebastian A. Zaat, Marcus J. Schultz, Eli Aguilera, Ana Motos, Tarek Senussi, Francesco Antonio Idone, Paolo Pelosi, Antonio Torres, Gianluigi Li Bassi and Nicole P. Juffermans

The diagnostic accuracy for ARDS of global versus regional lung ultrasound scores - a post hoc analysis of an observational study in invasively ventilated ICU patients

Semi-quantification of lung aeration by ultrasound helps to assess presence and extent of pulmonary pathologies, including the acute respiratory distress syndrome (ARDS). It is uncertain which lung regions add...

Authors: Luigi Pisani, Veronica Vercesi, Patricia S. I. van Tongeren, Wim K. Lagrand, Stije J. Leopold, Mischa A. M. Huson, Patricia C. Henwood, Andrew Walden, Marry R. Smit, Elisabeth D. Riviello, Paolo Pelosi, Arjen M. Dondorp and Marcus J. Schultz

Patient-ventilator asynchronies during mechanical ventilation: current knowledge and research priorities

Mechanical ventilation is common in critically ill patients. This life-saving treatment can cause complications and is also associated with long-term sequelae. Patient-ventilator asynchronies are frequent but ...

Authors: Candelaria de Haro, Ana Ochagavia, Josefina López-Aguilar, Sol Fernandez-Gonzalo, Guillem Navarra-Ventura, Rudys Magrans, Jaume Montanyà and Lluís Blanch

Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model

Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standa...

Authors: Derek J. B. Kleinveld, Mathijs R. Wirtz, Daan P. van den Brink, M. Adrie W. Maas, Joris J. T. H. Roelofs, J. Carel Goslings, Markus W. Hollmann and Nicole P. Juffermans

Why translational research matters: proceedings of the third international symposium on acute lung injury translational research (INSPIRES III)

Current treatment of acute respiratory distress syndrome (ARDS) in critically ill patients is limited to supportive measures including mechanical ventilation. It is our view that effective therapies for ARDS c...

Authors: Nicole P. Juffermans, Marcus Schultz, Lieuwe D. Bos, Oscar Penuelas, John Laffey and Jose A. Lorente

The role of hypercapnia in acute respiratory failure

The biological effects and physiological consequences of hypercapnia are increasingly understood. The literature on hypercapnia is confusing, and at times contradictory. On the one hand, it may have protective...

Authors: Luis Morales-Quinteros, Marta Camprubí-Rimblas, Josep Bringué, Lieuwe D. Bos, Marcus J. Schultz and Antonio Artigas

Power to mechanical power to minimize ventilator-induced lung injury?

Mechanical ventilation is a life-supportive therapy, but can also promote damage to pulmonary structures, such as epithelial and endothelial cells and the extracellular matrix, in a process referred to as vent...

Authors: Pedro Leme Silva, Lorenzo Ball, Patricia R. M. Rocco and Paolo Pelosi

Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury

In acute respiratory distress syndrome (ARDS), uncontrolled production of activators of coagulation and proinflammatory mediators results in a shift from an adequate local innate immune response to hypercoagul...

Authors: Jenny Juschten, Sarah Anne Ingelse, Martinus Adrianus Wilhelmus Maas, Armand Roelof Johan Girbes, Nicole Petra Juffermans, Marcus Josephus Schultz and Pieter Roel Tuinman

Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS

The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS). The current study explored the association between pulmonary depositions...

Authors: Friso M. de Beer, Mark P. V. Begieneman, Joris J. T. H. Roelofs, Janneke Horn, Hans W. M. Niessen, Marcus J. Schultz and Wim K. Lagrand