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Intensive Care Medicine Experimental
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  1. Microcirculation and macrohemodynamics are severely compromised during septic shock. However, the relationship between these two compartments needs to be further investigated. We hypothesized that early resusc...

    Authors: Alejandra López, Juan Carlos Grignola, Martín Angulo, Ignacio Alvez, Nicolás Nin, Gonzalo Lacuesta, Manuel Baz, Pablo Cardinal, Ivana Prestes, Juan P Bouchacourt, Juan Riva, Can Ince and Francisco Javier Hurtado
    Citation: Intensive Care Medicine Experimental 2015 3:14
    Content type: Research Published on:

  2. The surge in uptake of nasal continuous positive airway pressure (CPAP) for respiratory support in preterm infants has occurred in the absence of an authentic animal model. Such a model would allow investigati...

    Authors: Peter A Dargaville, Anna Lavizzari, Priscila Padoin, Don Black, Elroy Zonneveld, Elizabeth Perkins, Magdy Sourial, Anushi E Rajapaksa, Peter G Davis, Stuart B Hooper, Timothy JM Moss, Graeme R Polglase and David G Tingay
    Citation: Intensive Care Medicine Experimental 2015 3:13
    Content type: Methodology Published on:

  3. The mechanisms of sepsis mortality remain undefined. While there is some evidence of organ damage, it is not clear whether this damage alone is sufficient to cause death. Therefore, we aimed to examine contrib...

    Authors: Susanne Drechsler, Katrin M Weixelbaumer, Adelheid Weidinger, Pierre Raeven, Anna Khadem, Heinz Redl, Martijn van Griensven, Soheyl Bahrami, Daniel Remick, Andrey Kozlov and Marcin F Osuchowski
    Citation: Intensive Care Medicine Experimental 2015 3:12
    Content type: Research Published on:

  4. The aim of the study was to describe the effects of intra-abdominal hypertension (IAH) on regional and microcirculatory intestinal blood flow, renal blood flow, and urine output, as well as their response to i...

    Authors: Gonzalo Ferrara, Vanina S Kanoore Edul, Juan F Caminos Eguillor, Enrique Martins, Carlos Canullán, Héctor S Canales, Can Ince, Elisa Estenssoro and Arnaldo Dubin
    Citation: Intensive Care Medicine Experimental 2015 3:11
    Content type: Research Published on:

  6. Lethal and edema toxin contribute to shock and lethality with Bacillus anthracis. We showed previously in a 96-h sedated canine model that raxibacumab, a monoclonal antibody against protective antigen, augmented ...

    Authors: Kenneth E Remy, Xizhong Cui, Yan Li, Junfeng Sun, Steven B Solomon, Yvonne Fitz, Amisha V Barochia, Mariam Al-Hamad, Mahtab Moayeri, Stephen H Leppla and Peter Q Eichacker
    Citation: Intensive Care Medicine Experimental 2015 3:9
    Content type: Research Published on:

  7. The renin-angiotensin system (RAS) plays a role in the pathogenesis of ARDS, Angiotensin II (Ang-II) contributing to the pathogenesis of inflammation and fibrogenesis. Angiotensin-(1-7) (Ang-(1-7)) may antagon...

    Authors: Vanessa Zambelli, Giacomo Bellani, Roberto Borsa, Federico Pozzi, Alice Grassi, Margherita Scanziani, Vittoria Castiglioni, Serge Masson, Alessandra Decio, John G Laffey, Roberto Latini and Antonio Pesenti
    Citation: Intensive Care Medicine Experimental 2015 3:8
    Content type: Research Published on:

  8. The study of microglia and macrophage (M/M) morphology represents a key tool to understand the functional activation state and the pattern of distribution of these cells in acute brain injury. The identificati...

    Authors: Elisa R Zanier, Stefano Fumagalli, Carlo Perego, Francesca Pischiutta and Maria-Grazia De Simoni
    Citation: Intensive Care Medicine Experimental 2015 3:7
    Content type: Methodology Published on:

  9. Systolic left ventricular function during therapeutic hypothermia is found both to improve and to decline. We hypothesized that this discrepancy would depend on the heart rate and the variables used to assess ...

    Authors: Viesturs Kerans, Andreas Espinoza, Helge Skulstad, Per Steinar Halvorsen, Thor Edvardsen and Jan Frederik Bugge
    Citation: Intensive Care Medicine Experimental 2015 3:6
    Content type: Research Published on:

  10. Impaired coagulation contributes to the morbidity and mortality associated with septic shock. Whether abnormal platelet contraction adds to the bleeding tendency is unknown. Platelets contract when Ca2+-dependent...

    Authors: Benjamin AJ Reddi, Samantha M Iannella, Stephanie N O’Connor, Adam M Deane, Scott R Willoughby and David P Wilson
    Citation: Intensive Care Medicine Experimental 2015 3:5
    Content type: Research Published on:

  11. Orthogonal polarized spectral (OPS) and sidestream dark field (SDF) imaging video microscope devices were introduced for observation of the microcirculation but, due to technical limitations, have remained as ...

    Authors: Guclu Aykut, Gerke Veenstra, Claudia Scorcella, Can Ince and Christiaan Boerma
    Citation: Intensive Care Medicine Experimental 2015 3:4
    Content type: Research Published on:

  12. Lung failure after acute lung injury remains a challenge in different clinical settings. Various interventions for restoration of gas exchange have been investigated. Recruitment of collapsed alveoli by positi...

    Authors: Klaus Pfurtscheller, Stefan Ring, Elisabeth Beran, Erich Sorantin, Joachim Zobel, David Ganster, Alexander Avian and Gerfried Zobel
    Citation: Intensive Care Medicine Experimental 2015 3:3
    Content type: Research Published on:

  13. Sepsis is characterised by diminished vasopressor responsiveness. Vasoconstriction depends upon a balance: Ca2+-dependent myosin light-chain kinase promotes and Ca2+-independent myosin light-chain phosphatase (ML...

    Authors: Benjamin AJ Reddi, John F Beltrame, Richard L Young and David P Wilson
    Citation: Intensive Care Medicine Experimental 2015 3:2
    Content type: Research Published on:

  14. Sepsis has been shown to precondition the intact heart against ischaemia/reperfusion (IR) injury, and prior endotoxin exposure of cells in in vitro models has shown evidence of protection against subsequent simul...

    Authors: Criona M Walshe, John G Laffey, Leo Kevin and Daniel O’Toole
    Citation: Intensive Care Medicine Experimental 2015 3:1
    Content type: Research Published on:

  15. Decreased renal blood flow (RBF) and vasoconstriction are considered major mechanisms of contrast-induced acute kidney injury (CIAKI). To understand the severity and duration of such putative effects, we measu...

    Authors: Paolo Calzavacca, Ken Ishikawa, Michael Bailey, Clive N May and Rinaldo Bellomo
    Citation: Intensive Care Medicine Experimental 2014 2:32
    Content type: Research Published on:

  16. Up to 50% of septic patients develop acute kidney injury (AKI). The pathomechanism of septic AKI is poorly understood. Therefore, we established an innovative rodent model to characterize sepsis-induced AKI by...

    Authors: Martin A Schick, Wolfgang Baar, Sven Flemming, Nicolas Schlegel, Jakob Wollborn, Christopher Held, Reinhard Schneider, Robert W Brock, Norbert Roewer and Christian Wunder
    Citation: Intensive Care Medicine Experimental 2014 2:34
    Content type: Research Published on:

  17. Lung weight characterises severity of pulmonary oedema and predicts response to mechanical ventilation. The aim of this study was to evaluate the accuracy of quantitative analysis of thorax computed tomography...

    Authors: Alessandro Protti, Giacomo E Iapichino, Marta Milesi, Valentina Melis, Paola Pugni, Beatrice Comini, Massimo Cressoni and Luciano Gattinoni
    Citation: Intensive Care Medicine Experimental 2014 2:31
    Content type: Research Published on:

  18. It is unclear how complex pathophysiological mechanisms that result in early brain injury (EBI) after subarachnoid hemorrhage (SAH) are triggered. We investigate how peak intracranial pressure (ICP), amount of...

    Authors: Serge Marbacher, Volker Neuschmelting, Lukas Andereggen, Hans Rudolf Widmer, Michael von Gunten, Jukka Takala, Stephan M Jakob and Javier Fandino
    Citation: Intensive Care Medicine Experimental 2014 2:30
    Content type: Research Published on:

  19. Contrast-enhanced ultrasonography (CEUS) is a novel imaging modality to estimate microvascular perfusion. We aimed to assess renal cortical microcirculatory changes by CEUS during pharmacologically or mechanic...

    Authors: Antoine G Schneider, Paolo Calzavacca, Anthony Schelleman, Tim Huynh, Michael Bailey, Clive May and Rinaldo Bellomo
    Citation: Intensive Care Medicine Experimental 2014 2:33
    Content type: Research Published on:

  20. Extracorporeal membrane oxygenation (ECMO) circuits have been shown to sequester circulating blood compounds such as drugs based on their physicochemical properties. This study aimed to describe the dispositio...

    Authors: Kristine Estensen, Kiran Shekar, Elissa Robins, Charles McDonald, Adrian G Barnett and John F Fraser
    Citation: Intensive Care Medicine Experimental 2014 2:29
    Content type: Research Published on:

  21. Renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury and a frequent occurrence in critically ill patients. Renal IRI releases proinflammatory cytokines within the kidney that induce...

    Authors: Chieko Mitaka, May Khin Hnin Si, Miniwan Tulafu, Qi Yu, Tokujiro Uchida, Shinya Abe, Masanobu Kitagawa, Satoshi Ikeda, Yoshinobu Eishi and Makoto Tomita
    Citation: Intensive Care Medicine Experimental 2014 2:28
    Content type: Research Published on:

  22. Hub colonization after manipulation is responsible for 29% to 60% of catheter-related bloodstream infections (C-RBSI). Prevention can be achieved by the use of hub connectors, but its efficacy is generally bas...

    Authors: María Guembe, María Jesús Pérez-Granda, Luis Alcalá, Pablo Martín-Rabadán and Emilio Bouza
    Citation: Intensive Care Medicine Experimental 2014 2:27
    Content type: Research Published on:

  23. The hydraulic behavior of the renal compartment is poorly understood. In particular, the role of the renal capsule on the intrarenal pressure has not been thoroughly addressed to date. We hypothesized that pre...

    Authors: Pablo Cruces, Camila Salas, Pablo Lillo, Tatiana Salomon, Felipe Lillo and Daniel E Hurtado
    Citation: Intensive Care Medicine Experimental 2014 2:26
    Content type: Research Published on:

  42. Authors: E Briassouli, M Tzanoudaki, G Daikos, K Vardas, M Kanariou, C Routsi, S Nanas and G Briassoulis
    Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P14
    Content type: Poster presentation Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

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  • ISSN: 2197-425X (electronic)