Articles
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Citation: Intensive Care Medicine Experimental 2019 7:74
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Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons
Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. Clinically, the noble...
Citation: Intensive Care Medicine Experimental 2019 7:73 -
Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model
Improvement of single site cannulation for extracorporeal membrane oxygenation (ECMO) therapy is pivotal for reduction of patient morbidity and mortality in respiratory failure. To further improve the cardiopu...
Citation: Intensive Care Medicine Experimental 2019 7:72 -
Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?
Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent bi...
Citation: Intensive Care Medicine Experimental 2019 7:71 -
Ethical considerations about artificial intelligence for prognostication in intensive care
Prognosticating the course of diseases to inform decision-making is a key component of intensive care medicine. For several applications in medicine, new methods from the field of artificial intelligence (AI) ...
Citation: Intensive Care Medicine Experimental 2019 7:70 -
Report of the first AKI Round Table meeting: an initiative of the ESICM AKI Section
Critical Care Nephrology is an emerging sub-specialty of Critical Care. Despite increasing awareness about the serious impact of acute kidney injury (AKI) and renal replacement therapy (RRT), important knowled...
Citation: Intensive Care Medicine Experimental 2019 7:69 -
Methane and Inflammation - A Review (Fight Fire with Fire)
Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally co...
Citation: Intensive Care Medicine Experimental 2019 7:68 -
Moderately prolonged permissive hypotension results in reversible metabolic perturbation evaluated by intracerebral microdialysis - an experimental animal study
Damage control resuscitation (DCR) and damage control surgery (DCS) is the main strategy in patients with uncontrollable hemorrhagic shock. One aspect of DCR is permissive hypotension. However, the duration of...
Citation: Intensive Care Medicine Experimental 2019 7:67 -
Correction to: Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model
Please note that four authors (Logan Banadyga, Alixandra Albietz, Brad Pickering, and Gary Wong) have been erroneously omitted from the author list in the published original article [1].
Citation: Intensive Care Medicine Experimental 2019 7:66 -
Esmolol for cardioprotection during resuscitation with adrenaline in an ischaemic porcine cardiac arrest model
The effectiveness of adrenaline during resuscitation continues to be debated despite being recommended in international guidelines. There is evidence that the β-adrenergic receptor (AR) effects of adrenaline a...
Citation: Intensive Care Medicine Experimental 2019 7:65 -
Bench to bedside review: therapeutic modulation of nitric oxide in sepsis—an update
Nitric oxide is a signalling molecule with an extensive range of functions in both health and disease. Discovered in the 1980s through work that earned the Nobel prize, nitric oxide is an essential factor in r...
Citation: Intensive Care Medicine Experimental 2019 7:64 -
Needle-free connectors catheter-related bloodstream infections: a prospective randomized controlled trial
In the critically ill, catheter-related bloodstream infection can result from bacterial contamination of infusion hubs of intravascular catheters. Needle-free connectors (NFC) have been suggested to reduce the...
Citation: Intensive Care Medicine Experimental 2019 7:63 -
Combination of cardiac and thoracic pump theories in rodent cardiopulmonary resuscitation: a new method of three-side chest compression
High-quality cardiopulmonary resuscitation (HQ-CPR) is of paramount importance to improve neurological outcomes of cardiac arrest (CA). The purpose of this study was to evaluate chest compression methods by co...
Citation: Intensive Care Medicine Experimental 2019 7:62 -
Mechanical power at a glance: a simple surrogate for volume-controlled ventilation
Mechanical power is a summary variable including all the components which can possibly cause VILI (pressures, volume, flow, respiratory rate). Since the complexity of its mathematical computation is one of the...
Citation: Intensive Care Medicine Experimental 2019 7:61 -
Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury
An on-going debate exists as to whether partial ventilatory support is lung protective in an acute phase of ARDS. So far, the effects of different respiratory efforts on the development of ventilator-associate...
Citation: Intensive Care Medicine Experimental 2019 7:60 -
Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury
Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal, physiological variation in aeration and lung density in experimental lung injury. The ability of dCT to predict whole-lung values ...
Citation: Intensive Care Medicine Experimental 2019 7:59 -
Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response
Advanced age is associated with increased mortality in acute respiratory distress syndrome (ARDS) patients. Preclinical studies suggest that the host response to an injurious challenge is age-dependent. In ARD...
Citation: Intensive Care Medicine Experimental 2019 7:58 -
The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study
Septic cardiomyopathy (SCM) is common in sepsis and associated with increased morbidity and mortality. Left ventricular global longitudinal strain (LV GLS), measured by speckle tracking echocardiography, allow...
Citation: Intensive Care Medicine Experimental 2019 7:57 -
ESICM LIVES 2019
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 3):55 -
Respiratory and metabolic acidosis correction with the ADVanced Organ Support system
The lung, the kidney, and the liver are major regulators of acid-base balance. Acidosis due to the dysfunction of one or more organs can increase mortality, especially in critically ill patients. Supporting co...
Citation: Intensive Care Medicine Experimental 2019 7:56 -
Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model
There are currently limited data for the use of specific antiviral therapies for the treatment of Ebola virus disease (EVD). While there is anecdotal evidence that supportive care may be effective, there is a ...
Citation: Intensive Care Medicine Experimental 2019 7:54 -
Peroxynitrite decomposition catalyst reduces vasopressin requirement in ovine MRSA sepsis
Sepsis is one of the most frequent causes of death in the intensive care unit. Host vascular hypo-responsiveness to vasopressors during septic shock is one of the challenging problems. This study tested the hy...
Citation: Intensive Care Medicine Experimental 2019 7:12 -
Determining rhythmicity and determinism of temperature curves in septic and non-septic critically ill patients through chronobiological and recurrence quantification analysis: a pilot study
A few studies have demonstrated that critically ill patients exhibit circadian deregulation and reduced complexity of different time series, such as temperature.
Citation: Intensive Care Medicine Experimental 2019 7:53 -
The impact of the systemic inflammatory response on hepatic bacterial elimination in experimental abdominal sepsis
Bacterial translocation from the gut has been suggested to induce a systemic inflammatory response syndrome (SIRS) and organ dysfunction. The liver has a pivotal role in eliminating circulating bacteria enteri...
Citation: Intensive Care Medicine Experimental 2019 7:52 -
Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit
Extracorporeal membrane oxygenation (ECMO) is a life-saving modality used to manage cardiopulmonary failure refractory to conventional medical and surgical therapies. Despite advances in ECMO equipment, bleedi...
Citation: Intensive Care Medicine Experimental 2019 7:51 -
Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients
Accurate measurement of pulmonary oxygenation is important for classification of disease severity and quantification of outcomes in clinical studies. Currently, tension-based methods such as P/F ratio are in w...
Citation: Intensive Care Medicine Experimental 2019 7:49 -
Effect of landiolol on sex-related transcriptomic changes in the myocardium during sepsis
The aims of this study are to better understand phenotypic differences between male and female rats during sepsis, to characterise the contribution of the beta1-adrenergic blocker landiolol to septic cardiomyo...
Citation: Intensive Care Medicine Experimental 2019 7:50 -
Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill
Mechanical ventilation [MV] is a life-saving technique delivered to critically ill patients incapable of adequately ventilating and/or oxygenating due to respiratory or other disease processes. This necessaril...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):48 -
Development of a model for anemia of inflammation that is relevant to critical care
Anemia of inflammation (AI) is common in critically ill patients. Although this syndrome negatively impacts the outcome of critical illness, understanding of its pathophysiology is limited. Also, new therapies...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):47 -
Extracorporeal life support and systemic inflammation
Extracorporeal life support (ECLS) encompasses a wide range of extracorporeal modalities that offer short- and intermediate-term mechanical support to the failing heart or lung. Apart from the daily use of car...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):46 -
Histopathological changes of organ dysfunction in sepsis
Sepsis is a highly lethal disorder. Organ dysfunction in sepsis is not defined as a clinicopathological entity but rather by changes in clinical, physiological, or biochemical parameters. Pathogenesis and spec...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):45 -
The diagnostic accuracy for ARDS of global versus regional lung ultrasound scores - a post hoc analysis of an observational study in invasively ventilated ICU patients
Semi-quantification of lung aeration by ultrasound helps to assess presence and extent of pulmonary pathologies, including the acute respiratory distress syndrome (ARDS). It is uncertain which lung regions add...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):44 -
Patient-ventilator asynchronies during mechanical ventilation: current knowledge and research priorities
Mechanical ventilation is common in critically ill patients. This life-saving treatment can cause complications and is also associated with long-term sequelae. Patient-ventilator asynchronies are frequent but ...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):43 -
Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model
Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standa...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):42 -
Modulating the distribution and fate of exogenously delivered MSCs to enhance therapeutic potential: knowns and unknowns
Mesenchymal stem/stromal cells (MSCs) are undergoing intensive translational research for several debilitating conditions, including critical illnesses such as ARDS and sepsis. MSCs exert diverse biologic effe...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):41 -
Why translational research matters: proceedings of the third international symposium on acute lung injury translational research (INSPIRES III)
Current treatment of acute respiratory distress syndrome (ARDS) in critically ill patients is limited to supportive measures including mechanical ventilation. It is our view that effective therapies for ARDS c...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):40 -
The role of hypercapnia in acute respiratory failure
The biological effects and physiological consequences of hypercapnia are increasingly understood. The literature on hypercapnia is confusing, and at times contradictory. On the one hand, it may have protective...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):39 -
Power to mechanical power to minimize ventilator-induced lung injury?
Mechanical ventilation is a life-supportive therapy, but can also promote damage to pulmonary structures, such as epithelial and endothelial cells and the extracellular matrix, in a process referred to as vent...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):38 -
Manipulation of the microbiome in critical illness—probiotics as a preventive measure against ventilator-associated pneumonia
To describe the possible modes of action of probiotics and provide a systematic review of the current evidence on the efficacy of probiotics to prevent ventilator-associated pneumonia (VAP) in critically ill p...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):37 -
Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury
In acute respiratory distress syndrome (ARDS), uncontrolled production of activators of coagulation and proinflammatory mediators results in a shift from an adequate local innate immune response to hypercoagul...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):36 -
Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS
The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS). The current study explored the association between pulmonary depositions...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):35 -
Alveolar dynamics during mechanical ventilation in the healthy and injured lung
Mechanical ventilation is a life-saving therapy in patients with acute respiratory distress syndrome (ARDS). However, mechanical ventilation itself causes severe co-morbidities in that it can trigger ventilato...
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):34 -
Sepsis 2019
Citation: Intensive Care Medicine Experimental 2019 7(Suppl 2):33 -
Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model
Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death. The aim of this study wa...
Citation: Intensive Care Medicine Experimental 2019 7:32 -
Response to letter by Drs. Bottinger and van der Hoorn
Citation: Intensive Care Medicine Experimental 2019 7:31 -
Resistin directly inhibits bacterial killing in neutrophils
Sepsis-induced immunosuppression is a key factor contributing to the morbidity and mortality of critically ill patients, and polymorphonuclear neutrophil dysfunction is believed to be a hallmark of this immuno...
Citation: Intensive Care Medicine Experimental 2019 7:30 -
Comparison of the source and prognostic utility of cfDNA in trauma and sepsis
Circulating cell-free DNA (cfDNA) may contribute to the pathophysiology of post-injury inflammation and coagulation in trauma. However, the source and mechanism of release of cfDNA in trauma is not well unders...
Citation: Intensive Care Medicine Experimental 2019 7:29 -
Early herpes and TTV DNAemia in septic shock patients: a pilot study
Septic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation—as an early marker of immune suppression, or as a consequence of the later—is not known precisely...
Citation: Intensive Care Medicine Experimental 2019 7:28 -
Time-controlled adaptive ventilation (TCAV) accelerates simulated mucus clearance via increased expiratory flow rate
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in intensive care units. Distal airway mucus clearance has been shown to reduce VAP incidence. Studies suggest that mucus clearance...
Citation: Intensive Care Medicine Experimental 2019 7:27 -
Association between increased arterial stiffness and clinical outcomes in patients with early sepsis: a prospective observational cohort study
Conduit arteries, especially the aorta, play a major role in ensuring efficient cardiac function and optimal microvascular flow due to their viscoelastic properties. Studies in animals and on isolated arteries...
Citation: Intensive Care Medicine Experimental 2019 7:26
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- ISSN: 2197-425X (electronic)