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  1. The ex vivo human perfused lung model has enabled optimizing donor lungs for transplantation and delineating mechanisms of lung injury. Perfusate and airspace biomarkers are a proxy of the lung response to exp...

    Authors: Aleksandra Leligdowicz, James T. Ross, Nicolas Nesseler and Michael A. Matthay

    Citation: Intensive Care Medicine Experimental 2020 8:56

    Content type: Research

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  2. Change of the corrected flow time (Ftc) is a surrogate for tracking stroke volume (SV) in the intensive care unit. Multiple Ftc equations have been proposed; many have not had their diagnostic characteristics ...

    Authors: Jon-Émile S. Kenny, Igor Barjaktarevic, David C. Mackenzie, Andrew M. Eibl, Matthew Parrotta, Bradley F. Long and Joseph K. Eibl

    Citation: Intensive Care Medicine Experimental 2020 8:54

    Content type: Research

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  3. Immunological dysfunction is common in critically ill patients but its clinical significance and the optimal method to measure it are unknown. The level of tumor necrosis factor alpha (TNF-α) after ex-vivo who...

    Authors: Gabrielle Levin, J. Gordon Boyd, Andrew Day, Miranda Hunt, David M. Maslove, Patrick Norman, Nicole O’Callaghan, Stephanie Sibley and John Muscedere

    Citation: Intensive Care Medicine Experimental 2020 8:55

    Content type: Research

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  4. Extracorporeal carbon dioxide removal (ECCO2R) is a promising yet limited researched therapy for hypercapnic respiratory failure in acute respiratory distress syndrome and exacerbated chronic obstructive pulmonar...

    Authors: Leonie S. Schwärzel, Anna M. Jungmann, Nicole Schmoll, Frederik Seiler, Ralf M. Muellenbach, Joachim Schenk, Quoc Thai Dinh, Robert Bals, Philipp M. Lepper and Albert J. Omlor

    Citation: Intensive Care Medicine Experimental 2020 8:52

    Content type: Research

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  5. Heparin-binding protein (HBP) is a neutrophil-derived pro-inflammatory protein, an inducer of endothelial dysfunction and vascular permeability and a promising prognostic biomarker in sepsis. This exploratory ...

    Authors: Jonas Tverring, Niklas Nielsen, Josef Dankiewicz, Adam Linder, Fredrik Kahn and Per Åkesson

    Citation: Intensive Care Medicine Experimental 2020 8:51

    Content type: Research

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  6. Pseudo-pulseless electrical activity (pseudo-PEA) is a lifeless form of profound cardiac shock characterized by measurable cardiac mechanical activity without clinically detectable pulses. Pseudo-PEA may const...

    Authors: Alexander L. Lindqwister, Joshua W. Lampe, Jeffrey R. Gould, Christopher L. Kaufman, Karen L. Moodie and Norman A. Paradis

    Citation: Intensive Care Medicine Experimental 2020 8:50

    Content type: Research

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  7. The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We hypothesized that differences in microbiota composition across vendor...

    Authors: Nora S. Wolff, Max C. Jacobs, Bastiaan W. Haak, Joris J. T. H. Roelofs, Alex F. de Vos, Floor Hugenholtz and W. Joost Wiersinga

    Citation: Intensive Care Medicine Experimental 2020 8:47

    Content type: Research

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  8. Non-invasive and lung-protective ventilation techniques may improve outcomes for patients with an acute exacerbation of chronic obstructive pulmonary disease or moderate acute respiratory distress syndrome by ...

    Authors: Alexandra G. May, Ryan A. Orizondo, Brian J. Frankowski, Sang-Ho Ye, Ergin Kocyildirim, William R. Wagner, Jonathan D’Cunha and William J. Federspiel

    Citation: Intensive Care Medicine Experimental 2020 8:45

    Content type: Research

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  9. Alteration of the mechanisms of cerebral blood flow (CBF) regulation might contribute to the pathophysiology of sepsis-associated encephalopathy (SAE). However, previous clinical studies on dynamic cerebral au...

    Authors: Lorenzo Ferlini, Fuhong Su, Jacques Creteur, Fabio Silvio Taccone and Nicolas Gaspard

    Citation: Intensive Care Medicine Experimental 2020 8:44

    Content type: Research

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  10. This study aimed to assess right ventricular (RV) function during cardiogenic shock due to acute left ventricular (LV) failure, including during LV unloading with Impella CP and an added moderate dose of norep...

    Authors: Jakob Josiassen, Ole Kristian Lerche Helgestad, Nanne Louise Junker Udesen, Ann Banke, Peter Hartmund Frederiksen, Janus Adler Hyldebrandt, Henrik Schmidt, Lisette Okkels Jensen, Christian Hassager, Hanne Berg Ravn and Jacob E. Møller

    Citation: Intensive Care Medicine Experimental 2020 8:41

    Content type: Research

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  11. Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies. To ensure that new therapies ...

    Authors: Jane Fisher, Chiara Pavan, Luisa S. Ohlmeier, Bo Nilson, Iben Lundgaard, Adam Linder and Peter Bentzer

    Citation: Intensive Care Medicine Experimental 2020 8:40

    Content type: Methodology

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  12. Positive end-expiratory pressure (PEEP) is used to optimize oxygenation by preventing alveolar collapse. However, PEEP can potentially decrease cardiac output through cardiopulmonary interactions. The effect o...

    Authors: Yosef Levenbrown, Md Jobayer Hossain, James P. Keith, Katlyn Burr, Anne Hesek and Thomas Shaffer

    Citation: Intensive Care Medicine Experimental 2020 8:36

    Content type: Research

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  13. Noise levels on intensive care units (ICUs) are typically elevated. While many studies reported negative effects of ICU ambient sounds on patients, only few investigated noise as a factor to influence well-bei...

    Authors: Nadine Schmidt, Stephan M. Gerber, Björn Zante, Tom Gawliczek, Alvin Chesham, Klemens Gutbrod, René M. Müri, Tobias Nef, Joerg C. Schefold and Marie-Madlen Jeitziner

    Citation: Intensive Care Medicine Experimental 2020 8:34

    Content type: Research

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  14. Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.

    Authors: Clifford S. Deutschman, Judith Hellman, Ricard Ferrer Roca, Daniel De Backer and Craig M. Coopersmith

    Citation: Intensive Care Medicine Experimental 2020 8:31

    Content type: Consensus document

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  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Emma M. Chang, Andrew Bretherick, Gordon B. Drummond and J. Kenneth Baillie

    Citation: Intensive Care Medicine Experimental 2020 8:30

    Content type: Correction

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    The original article was published in Intensive Care Medicine Experimental 2019 7:49

  16. Primary blast lung injury (PBLI) presents as a syndrome of respiratory distress and haemoptysis resulting from explosive shock wave exposure and is a frequent cause of mortality and morbidity in both military ...

    Authors: Timothy E. Scott, Anup Das, Mainul Haque, Declan G. Bates and Jonathan G. Hardman

    Citation: Intensive Care Medicine Experimental 2020 8:26

    Content type: Research

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  17. Plasma-Lyte is a balanced, crystalloid intravenous fluid which has been shown to avoid the hyperchloremic metabolic acidosis associated with 0.9% sodium chloride. Data on physical, pH and chemical compatibilit...

    Authors: Sophie Hammond, Andrew Wignell, Paul Cooling, David A. Barrett and Patrick Davies

    Citation: Intensive Care Medicine Experimental 2020 8:25

    Content type: Research

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  18. 3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) abuse is frequent, and overdosing might cause severe and eventually lethal multi-organ failure. To date, there is no causal therapy of MDMA intoxication and ...

    Authors: Corinna N. Lang, Michaela J. Sommer, Merja A. Neukamm, Dawid L. Staudacher, Alexander Supady, Christoph Bode, Daniel Duerschmied and Achim Lother

    Citation: Intensive Care Medicine Experimental 2020 8:21

    Content type: Research

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  19. Discovery science, a term which encompasses basic, translational, and computational science with the aim to discover new therapies, has advanced critical care. By combining knowledge on inflammatory and genomi...

    Authors: Nicole P. Juffermans, Peter Radermacher and John G. Laffey

    Citation: Intensive Care Medicine Experimental 2020 8:17

    Content type: Commentary

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  20. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used to treat patients with refractory severe heart failure. Large animal models are developed to help understand physiology an...

    Authors: Silver Heinsar, Sacha Rozencwajg, Jacky Suen, Gianluigi Li Bassi, Maximilian Malfertheiner, Leen Vercaemst, Lars Mikael Broman, Matthieu Schmidt, Alain Combes, Indrek Rätsep, John F. Fraser and Jonathan E. Millar

    Citation: Intensive Care Medicine Experimental 2020 8:16

    Content type: Review

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  21. An efficient and accurate method of respiratory rate measurement is still missing in hospital general wards and triage. The goal of this study is to propose a method of respiratory rate measurement that has a ...

    Authors: Gurpreet Singh, Augustine Tee, Thanawin Trakoolwilaiwan, Aza Taha and Malini Olivo

    Citation: Intensive Care Medicine Experimental 2020 8:15

    Content type: Research

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  22. Invasive mechanical ventilation is lifesaving in the setting of severe acute respiratory failure but can cause ventilation-induced lung injury. Advances in extracorporeal CO2 removal (ECCO2R) technologies may fac...

    Authors: Ingeborg Hospach, Jacques Goldstein, Kai Harenski, John G. Laffey, Dominique Pouchoulin, Manuela Raible, Stefanie Votteler and Markus Storr

    Citation: Intensive Care Medicine Experimental 2020 8:14

    Content type: Research

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  23. Several therapeutic strategies to rescue the brain from ischemic injury have improved outcomes after stroke; however, there is no treatment as yet for reperfusion injury, the secondary damage caused by necessa...

    Authors: Bruna Pescador Mendonça, Juliano Dos Santos Cardoso, Monique Michels, Ana Carolina Vieira, Diogo Wendhausen, Andressa Manfredini, Mervyn Singer, Felipe Dal-Pizzol and Alex Dyson

    Citation: Intensive Care Medicine Experimental 2020 8:13

    Content type: Research

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  24. Patients often develop infectious complications after severe trauma. No biomarkers exist that enable early identification of patients who are at risk. Neutrophils are important immune cells that combat these i...

    Authors: Lillian Hesselink, Roy Spijkerman, Emma de Fraiture, Suzanne Bongers, Karlijn J. P. Van Wessem, Nienke Vrisekoop, Leo Koenderman, Luke P. H. Leenen and Falco Hietbrink

    Citation: Intensive Care Medicine Experimental 2020 8:12

    Content type: Research

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  25. Real-time bedside information on regional ventilation and perfusion during mechanical ventilation (MV) may help to elucidate the physiological and pathophysiological effects of MV settings in healthy and injur...

    Authors: João Batista Borges, John N. Cronin, Douglas C. Crockett, Göran Hedenstierna, Anders Larsson and Federico Formenti

    Citation: Intensive Care Medicine Experimental 2020 8:10

    Content type: Research

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  26. Sepsis, a dysregulated host response to infection with results in organ dysfunction, has been a major challenge to the development of effective therapeutics. Sepsis-associated acute kidney injury (S-AKI) resul...

    Authors: Xiaoyan Wen, Shengnan Li, Alicia Frank, Xiukai Chen, David Emlet, Neil A. Hukriede and John A. Kellum

    Citation: Intensive Care Medicine Experimental 2020 8:9

    Content type: Research

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  27. Human mesenchymal stem/stromal cells (hMSCs) represent a promising therapeutic strategy for ventilator-induced lung injury (VILI) and acute respiratory distress syndrome. Translational challenges include resto...

    Authors: Shahd Horie, Sean Gaynard, Mary Murphy, Frank Barry, Michael Scully, Daniel O’Toole and John G. Laffey

    Citation: Intensive Care Medicine Experimental 2020 8:8

    Content type: Research

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  28. Animal studies reporting immune checkpoint inhibitors (CPIs) improved host defense and survival during bacterial sepsis provided one basis for phase I CPI sepsis trials. We performed a systematic review and me...

    Authors: Lindsay M. Busch, Junfeng Sun, Xizhong Cui, Peter Q. Eichacker and Parizad Torabi-Parizi

    Citation: Intensive Care Medicine Experimental 2020 8:7

    Content type: Research

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  29. Compared to continuous vibrating mesh nebulizer (VMN), inspiration synchronized VMN has shown increased inhaled dose during noninvasive ventilation; however, its use during aerosol delivery via high-flow nasal...

    Authors: Jie Li, Wei Wu and James B. Fink

    Citation: Intensive Care Medicine Experimental 2020 8:6

    Content type: Research

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  30. After publication of this supplement [1], it was brought to our attention that the author ‘L. Vegnuti’ has been erroneously omitted from the author list of the following abstract.

    Authors: B. Ferro, R. Tofani, L. Vegnuti, G. Borelli, L. Gargani and P. Roncucci

    Citation: Intensive Care Medicine Experimental 2020 8:4

    Content type: Correction

    Published on:

    The original article was published in Intensive Care Medicine Experimental 2019 7:55

  31. Targeted temperature management (TTM) of 32 to 34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 indicated benefit on survival and neurological outcome. In ...

    Authors: Hilmer Olai, Gustav Thornéus, Hannah Watson, Malcolm Macleod, Jonathan Rhodes, Hans Friberg, Niklas Nielsen, Tobias Cronberg and Tomas Deierborg

    Citation: Intensive Care Medicine Experimental 2020 8:3

    Content type: Research

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  32. Global end-diastolic volume (GEDV) measured by transpulmonary thermodilution is regarded as indicator of cardiac preload. A bolus of cold saline injected in a central vein travels through the heart and lung, b...

    Authors: Aleksej Akohov, Christoph Barner, Steffen Grimmer, Roland CE Francis and Stefan Wolf

    Citation: Intensive Care Medicine Experimental 2020 8:1

    Content type: Research

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  33. Improvement of single site cannulation for extracorporeal membrane oxygenation (ECMO) therapy is pivotal for reduction of patient morbidity and mortality in respiratory failure. To further improve the cardiopu...

    Authors: Ruslan Natanov, Abdurasul Khalikov, Faikah Gueler, Ulrich Maus, Erin C. Boyle, Axel Haverich, Christian Kühn and Nodir Madrahimov

    Citation: Intensive Care Medicine Experimental 2019 7:72

    Content type: Research

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  34. Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent bi...

    Authors: Mathun Kuganesan, Kavitej Samra, Eloise Evans, Mervyn Singer and Alex Dyson

    Citation: Intensive Care Medicine Experimental 2019 7:71

    Content type: Review

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  35. Prognosticating the course of diseases to inform decision-making is a key component of intensive care medicine. For several applications in medicine, new methods from the field of artificial intelligence (AI) ...

    Authors: Michael Beil, Ingo Proft, Daniel van Heerden, Sigal Sviri and Peter Vernon van Heerden

    Citation: Intensive Care Medicine Experimental 2019 7:70

    Content type: Review

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  36. Critical Care Nephrology is an emerging sub-specialty of Critical Care. Despite increasing awareness about the serious impact of acute kidney injury (AKI) and renal replacement therapy (RRT), important knowled...

    Authors: M. Ostermann, A. Schneider, T. Rimmele, I. Bobek, M. van Dam, M. Darmon, L. Forni, O. Joannes-Boyau, M. Joannidis, M. Legrand, J. Prowle, A. Zarbock and E. Hoste

    Citation: Intensive Care Medicine Experimental 2019 7:69

    Content type: Methodology

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  37. Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally co...

    Authors: Marietta Zita Poles, László Juhász and Mihály Boros

    Citation: Intensive Care Medicine Experimental 2019 7:68

    Content type: Review

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  38. Damage control resuscitation (DCR) and damage control surgery (DCS) is the main strategy in patients with uncontrollable hemorrhagic shock. One aspect of DCR is permissive hypotension. However, the duration of...

    Authors: Rasmus Peter Jakobsen, Troels Halfeld Nielsen, Simon Mølstrøm, Carl-Henrik Nordström, Asger Granfeldt and Palle Toft

    Citation: Intensive Care Medicine Experimental 2019 7:67

    Content type: Research

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  39. Please note that four authors (Logan Banadyga, Alixandra Albietz, Brad Pickering, and Gary Wong) have been erroneously omitted from the author list in the published original article [1].

    Authors: Guillaume Poliquin, Duane Funk, Shane Jones, Kaylie Tran, Charlene Ranadheera, Mable Hagan, Kevin Tierney, Allen Grolla, Amrinder Dhaliwal, Alexander Bello, Anders Leung, Cory Nakamura, Darwyn Kobasa, Darryl Falzarano, Lauren Garnett, Hugues Fausther Bovendo…

    Citation: Intensive Care Medicine Experimental 2019 7:66

    Content type: Correction

    Published on:

    The original article was published in Intensive Care Medicine Experimental 2019 7:54