Citation: Intensive Care Medicine Experimental 2021 9:2
Articles
Page 1 of 31
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The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients
Mechanical ventilation can induce or even worsen lung injury, at least in part via overdistension caused by too large volumes or too high pressures. The complement system has been suggested to play a causative...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):74
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Effect of routine vs on-demand nebulization of acetylcysteine with salbutamol on accumulation of airway secretions in endotracheal tubes: substudy of a randomized clinical trial
Accumulated airway secretions in the endotracheal tube increase work of breathing and may favor airway colonization eventually leading to pneumonia. The aim of this preplanned substudy of the ‘Preventive Nebul...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):71
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Comparison of direct and indirect models of early induced acute lung injury
The animal experimental counterpart of human acute respiratory distress syndrome (ARDS) is acute lung injury (ALI). Most models of ALI involve reproducing the clinical risk factors associated with human ARDS, ...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):62
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The predictive validity for mortality of the driving pressure and the mechanical power of ventilation
Outcome prediction in critically ill patients under invasive ventilation remains extremely challenging. The driving pressure (ΔP) and the mechanical power of ventilation (MP) are associated with patient-center...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):60
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Continuous external negative pressure improves oxygenation and respiratory mechanics in Experimental Lung Injury in Pigs – A pilot proof-of-concept trial
Continuous external negative pressure (CENP) during positive pressure ventilation can recruit dependent lung regions. We hypothesised that CENP applied regionally to the thorax or the abdomen only, increases t...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):49
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Liver–lung interactions in acute respiratory distress syndrome
Patients with liver diseases are at high risk for the development of acute respiratory distress syndrome (ARDS). The liver is an important organ that regulates a complex network of mediators and modulates orga...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):48
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Alkaline phosphatase in pulmonary inflammation—a translational study in ventilated critically ill patients and rats
Alkaline phosphatase (AP), a dephosphorylating enzyme, is involved in various physiological processes and has been shown to have anti-inflammatory effects.
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):46
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Prognostic classification based on P/F and PEEP in invasively ventilated ICU patients with hypoxemia—insights from the MARS study
Outcome prediction in patients with acute respiratory distress syndrome (ARDS) greatly improves when patients are reclassified based on predefined arterial oxygen partial pressure to fractional inspired oxygen...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):43
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Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model
In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction o...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):42
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Effects of higher PEEP and recruitment manoeuvres on mortality in patients with ARDS: a systematic review, meta-analysis, meta-regression and trial sequential analysis of randomized controlled trials
In patients with acute respiratory distress syndrome (ARDS), lung recruitment could be maximised with the use of recruitment manoeuvres (RM) or applying a positive end-expiratory pressure (PEEP) higher than wh...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):39
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Impact of downstream effects of glucocorticoid receptor dysfunction on organ function in critical illness-associated systemic inflammation
Glucocorticoids (GCs) are stress hormones that regulate developmental and physiological processes and are among the most potent anti-inflammatory drugs to suppress chronic and acute inflammation. GCs act throu...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):37
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H2S in acute lung injury: a therapeutic dead end(?)
This review addresses the plausibility of hydrogen sulfide (H2S) therapy for acute lung injury (ALI) and circulatory shock, by contrasting the promising preclinical results to the present clinical reality. The re...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):33
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Fluids in ARDS: more pros than cons
In acute respiratory distress syndrome (ARDS), increased pulmonary vascular permeability makes the lung vulnerable to edema. The use of conservative as compared to liberal fluid strategies may increase the num...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):32
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Metabolic substrate utilization in stress-induced immune cells
Immune cell activation leads to the acquisition of new functions, such as proliferation, chemotaxis, and cytokine production. These functional changes require continuous metabolic adaption in order to sustain ...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):28
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Comparative effects of flow vs. volume-controlled one-lung ventilation on gas exchange and respiratory system mechanics in pigs
Flow-controlled ventilation (FCV) allows expiratory flow control, reducing the collapse of the airways during expiration. The performance of FCV during one-lung ventilation (OLV) under intravascular normo- and...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):24
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Ischaemic stroke-induced distal organ damage: pathophysiology and new therapeutic strategies
Acute ischaemic stroke is associated with a high risk of non-neurological complications, which include respiratory failure, cardiovascular dysfunction, kidney and liver injury, and altered immune and endocrine...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):23
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Extracellular vesicles as regulators of kidney function and disease
Extracellular vesicles (EVs) are small, lipid bilayer-delimited particles of cellular origin that recently gained increasing attention for their potential use as diagnostic biomarkers, and beyond that for thei...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):22
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Role of the adaptive immune response in sepsis
Sepsis is a syndrome of shock and dysfunction of multiple vital organs that is caused by an uncontrolled immune response to infection and has a high mortality rate. There are no therapies for sepsis, and it ha...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):20
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Pathophysiology and clinical consequences of arterial blood gases and pH after cardiac arrest
Post cardiac arrest syndrome is associated with high morbidity and mortality, which is related not only to a poor neurological outcome but also to respiratory and cardiovascular dysfunctions. The control of ga...
Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):19
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Changes in left ventricular electromechanical relations during targeted hypothermia
Targeted hypothermia, as used after cardiac arrest, increases electrical and mechanical systolic duration. Differences in duration of electrical and mechanical systole are correlated to ventricular arrhythmias...
Citation: Intensive Care Medicine Experimental 2020 8:76
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Citation: Intensive Care Medicine Experimental 2020 8(Suppl 2):73
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Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation
COVID19 is caused by the SARS-CoV-2 virus and has been associated with severe inflammation leading to organ dysfunction and mortality. Our aim was to profile the transcriptome in leukocytes from critically ill...
Citation: Intensive Care Medicine Experimental 2020 8:75
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Endotoxemia and circulating bacteriome in severe COVID-19 patients
When severe, COVID-19 shares many clinical features with bacterial sepsis. Yet, secondary bacterial infection is uncommon. However, as epithelium is injured and barrier function is lost, bacterial products ent...
Citation: Intensive Care Medicine Experimental 2020 8:72
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Flow-controlled ventilation during EVLP improves oxygenation and preserves alveolar recruitment
Ex vivo lung perfusion (EVLP) is a widespread accepted platform for preservation and evaluation of donor lungs prior to lung transplantation (LTx). Standard lungs are ventilated using volume-controlled ventila...
Citation: Intensive Care Medicine Experimental 2020 8:70
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Autonomic nervous system activity and the risk of nosocomial infection in critically ill patients with brain injury
Nosocomial infection contributes to adverse outcome after brain injury. This study investigates whether autonomic nervous system activity is associated with a decreased host immune response in patients followi...
Citation: Intensive Care Medicine Experimental 2020 8:69
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SARS-CoV-2 analysis on environmental surfaces collected in an intensive care unit: keeping Ernest Shackleton’s spirit
Intensive care unit workers are at high risk of acquiring COVID-19 infection, especially when performing invasive techniques and certain procedures that generate aerosols (< 5 μm). Therefore, one of the object...
Citation: Intensive Care Medicine Experimental 2020 8:68
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Hydrocortisone decreases lethality and inflammatory cytokine and nitric oxide production in rats challenged with B. anthracis cell wall peptidoglycan
Lethal B. anthracis infection produces high proinflammatory peptidoglycan (PGN) burdens in hosts. We investigated whether the lethality and inflammation anthrax PGN can produce are related.
Citation: Intensive Care Medicine Experimental 2020 8:67
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Does hemofiltration protect the brain after head trauma? An experimental study in rabbits
Traumatic brain injury (TBI) is one of the most frequent and severe neurological diseases. In the last few decades, significant advances have been made in TBI pathophysiology and monitoring, however new treatm...
Citation: Intensive Care Medicine Experimental 2020 8:66
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Citation: Intensive Care Medicine Experimental 2020 8:65
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Regional venous–arterial CO2 to arterial–venous O2 content difference ratio in experimental circulatory shock and hypoxia
Venous–arterial carbon dioxide (CO2) to arterial–venous oxygen (O2) content difference ratio (Cv-aCO2/Ca-vO2) > 1 is supposed to be both sensitive and specific for anaerobic metabolism. What regional hemodynamic ...
Citation: Intensive Care Medicine Experimental 2020 8:64
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Veno-venous ECMO as a platform to evaluate lung lavage and surfactant replacement therapy in an animal model of severe ARDS
There are limited therapeutic options directed at the underlying pathological processes in acute respiratory distress syndrome (ARDS). Experimental therapeutic strategies have targeted the protective systems t...
Citation: Intensive Care Medicine Experimental 2020 8:63
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Neuromuscular blocking agents in acute respiratory distress syndrome: updated systematic review and meta-analysis of randomized trials
Existing clinical practice guidelines support the use of neuromuscular blocking agents (NMBA) in acute respiratory distress syndrome (ARDS); however, a recent large randomized clinical trial (RCT) has question...
Citation: Intensive Care Medicine Experimental 2020 8:61
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Electrolyte-based calculation of fluid shifts after infusing 0.9% saline in severe hyperglycemia
Early treatment of severe hyperglycemia involves large shifts of body fluids that entail a risk of hemodynamic instability. We studied the feasibility of applying a new electrolyte equation that estimates the ...
Citation: Intensive Care Medicine Experimental 2020 8:59
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Right ventricular stroke volume assessed by pulmonary artery pulse contour analysis
Stroke volume measurement should provide estimates of acute treatment responses. The current pulse contour method estimates left ventricle stroke volume. Heart-lung interactions change right ventricular stroke...
Citation: Intensive Care Medicine Experimental 2020 8:58
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Citation: Intensive Care Medicine Experimental 2020 8:57
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The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung
The ex vivo human perfused lung model has enabled optimizing donor lungs for transplantation and delineating mechanisms of lung injury. Perfusate and airspace biomarkers are a proxy of the lung response to exp...
Citation: Intensive Care Medicine Experimental 2020 8:56
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Diagnostic characteristics of 11 formulae for calculating corrected flow time as measured by a wearable Doppler patch
Change of the corrected flow time (Ftc) is a surrogate for tracking stroke volume (SV) in the intensive care unit. Multiple Ftc equations have been proposed; many have not had their diagnostic characteristics ...
Citation: Intensive Care Medicine Experimental 2020 8:54
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The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients
Immunological dysfunction is common in critically ill patients but its clinical significance and the optimal method to measure it are unknown. The level of tumor necrosis factor alpha (TNF-α) after ex-vivo who...
Citation: Intensive Care Medicine Experimental 2020 8:55
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Citation: Intensive Care Medicine Experimental 2020 8:53
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A mock circulation loop to test extracorporeal CO2 elimination setups
Extracorporeal carbon dioxide removal (ECCO2R) is a promising yet limited researched therapy for hypercapnic respiratory failure in acute respiratory distress syndrome and exacerbated chronic obstructive pulmonar...
Citation: Intensive Care Medicine Experimental 2020 8:52
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Repeated measures of Heparin-binding protein (HBP) and procalcitonin during septic shock: biomarker kinetics and association with cardiovascular organ dysfunction
Heparin-binding protein (HBP) is a neutrophil-derived pro-inflammatory protein, an inducer of endothelial dysfunction and vascular permeability and a promising prognostic biomarker in sepsis. This exploratory ...
Citation: Intensive Care Medicine Experimental 2020 8:51
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Intravenous calcium as a pressor in a swine model of hypoxic pseudo-pulseless electrical mechanical activity—a preliminary report
Pseudo-pulseless electrical activity (pseudo-PEA) is a lifeless form of profound cardiac shock characterized by measurable cardiac mechanical activity without clinically detectable pulses. Pseudo-PEA may const...
Citation: Intensive Care Medicine Experimental 2020 8:50
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Vendor effects on murine gut microbiota and its influence on lipopolysaccharide-induced lung inflammation and Gram-negative pneumonia
The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We hypothesized that differences in microbiota composition across vendor...
Citation: Intensive Care Medicine Experimental 2020 8:47
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In vivo testing of the low-flow CO2 removal application of a compact, platform respiratory device
Non-invasive and lung-protective ventilation techniques may improve outcomes for patients with an acute exacerbation of chronic obstructive pulmonary disease or moderate acute respiratory distress syndrome by ...
Citation: Intensive Care Medicine Experimental 2020 8:45
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Cerebral autoregulation and neurovascular coupling are progressively impaired during septic shock: an experimental study
Alteration of the mechanisms of cerebral blood flow (CBF) regulation might contribute to the pathophysiology of sepsis-associated encephalopathy (SAE). However, previous clinical studies on dynamic cerebral au...
Citation: Intensive Care Medicine Experimental 2020 8:44
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Unloading using Impella CP during profound cardiogenic shock caused by left ventricular failure in a large animal model: impact on the right ventricle
This study aimed to assess right ventricular (RV) function during cardiogenic shock due to acute left ventricular (LV) failure, including during LV unloading with Impella CP and an added moderate dose of norep...
Citation: Intensive Care Medicine Experimental 2020 8:41
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A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis
Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies. To ensure that new therapies ...
Citation: Intensive Care Medicine Experimental 2020 8:40
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CytoSorb removes MDMA in vitro, but is it an effective therapy in vivo?
3,4-Methylenedioxymethamphetamine intoxication can result in potentially lethal multi-organ failure, for which the current treatment is largely supportive. Recently, a report of the use of the CytoSorb device ...
Citation: Intensive Care Medicine Experimental 2020 8:38
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The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation
Positive end-expiratory pressure (PEEP) is used to optimize oxygenation by preventing alveolar collapse. However, PEEP can potentially decrease cardiac output through cardiopulmonary interactions. The effect o...
Citation: Intensive Care Medicine Experimental 2020 8:36
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- ISSN: 2197-425X (electronic)