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  1. Content type: Research

    Haemostasis and correction of hypovolemia are the pillars of early haemorrhage shock (HS) management. Vasopressors, which are not recommended as first-line therapy, are an alternative to aggressive fluid resus...

    Authors: Sophie Dunberry-Poissant, Kim Gilbert, Caroline Bouchard, Frédérique Baril, Anne-Marie Cardinal, Sydnée L’Ecuyer, Mathieu Hylands, François Lamontagne, Guy Rousseau and Emmanuel Charbonney

    Citation: Intensive Care Medicine Experimental 2018 6:47

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  2. Content type: Research

    Cerebral regional microcirculation is altered following severe head injury. In addition to tissue disruption, partial pressure of tissue oxygenation is impaired due to an increase in the oxygen tissue gradient...

    Authors: Judith Bellapart, Kylie Cuthbertson, Kimble Dunster, Sara Diab, David G. Platts, Christopher Raffel, Levon Gabrielian, Adrian Barnett, Jennifer Paratz, Rob Boots and John F. Fraser

    Citation: Intensive Care Medicine Experimental 2018 6:46

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  3. Content type: Research

    Selective brain cooling (SBC) methods could alleviate the complications associated with systemic hypothermia. The authors (MFB, LK, and T-YL) have developed a simple and an effective nasopharyngeal SBC method ...

    Authors: Mohammad Fazel Bakhsheshi, Lynn Keenliside and Ting-Yim Lee

    Citation: Intensive Care Medicine Experimental 2018 6:45

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  4. Content type: Research

    In rodents, intravenous sulfide protected against spinal cord ischemia/reperfusion (I/R) injury during aortic balloon occlusion. We investigated the effect of intravenous sulfide on aortic occlusion-induced po...

    Authors: Andre Bredthauer, Karla Lehle, Angelika Scheuerle, Hubert Schelzig, Oscar McCook, Peter Radermacher, Csaba Szabo, Martin Wepler and Florian Simon

    Citation: Intensive Care Medicine Experimental 2018 6:44

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  5. Content type: Research

    We previously evaluated the efficacy of a ventilatory strategy to achieve expiratory flow bias and positive end-expiratory pressure (EFB + PEEP) or the Trendelenburg position (TP) for the prevention of ventila...

    Authors: Gianluigi Li Bassi, Raquel Guillamat Prats, Antonio Artigas, Eli Aguilera Xiol, Joan-Daniel Marti, Otavio T. Ranzani, Montserrat Rigol, Laia Fernandez, Andrea Meli, Denise Battaglini, Nestor Luque, Miguel Ferrer, Ignacio Martin-Loeches, Pedro Póvoa, Davide Chiumello, Paolo Pelosi…

    Citation: Intensive Care Medicine Experimental 2018 6:42

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  6. Content type: Research

    Sepsis is associated with disturbed glucose metabolism and reduced mitochondrial activity and biogenesis, ultimately leading to multiple organ dysfunction, e.g., acute kidney injury (AKI). Cystathionine-γ-lyas...

    Authors: Tamara Merz, Martin Wepler, Benedikt Nußbaum, Josef Vogt, Enrico Calzia, Rui Wang, Csaba Szabo, Peter Radermacher and Oscar McCook

    Citation: Intensive Care Medicine Experimental 2018 6:43

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  7. Content type: Research

    Both the hydrogen sulfide/cystathionine-γ-lyase (H2S/CSE) and oxytocin/oxytocin receptor (OT/OTR) systems have been reported to be cardioprotective. H2S can stimulate OT release, thereby affecting blood volume an...

    Authors: Tamara Merz, Britta Lukaschewski, Daniela Wigger, Aileen Rupprecht, Martin Wepler, Michael Gröger, Clair Hartmann, Matthew Whiteman, Csaba Szabo, Rui Wang, Christiane Waller, Peter Radermacher and Oscar McCook

    Citation: Intensive Care Medicine Experimental 2018 6:41

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  8. Content type: Research

    Several indices exist to assess cerebral perfusion after cardiac arrest (CA). We aimed to investigate a new approach allowing absolute flow and microvascular resistance measurement based on selective arterial ...

    Authors: Julien Adjedj, Fabien Picard, Maarten Vanhaverbeke, Bernard De Bruyne, Alain Cariou, Ming Wu, Stefan Janssens and Olivier Varenne

    Citation: Intensive Care Medicine Experimental 2018 6:39

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  9. Content type: Research

    In critically ill patients, drug incompatibilities frequently occur because of the number of drugs to be administered through a limited number of infusion lines. These are among the main causes of particulate ...

    Authors: Malik Benlabed, Anthony Martin Mena, Romain Gaudy, Maxime Perez, Stéphanie Genay, Jean-Daniel Hecq, Pascal Odou, Gilles Lebuffe and Bertrand Décaudin

    Citation: Intensive Care Medicine Experimental 2018 6:38

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  10. Content type: Research

    Epithelial and endothelial barrier integrity, essential for homeostasis, is maintained by cellular boarder structures known as tight junctions (TJs). In critical illness, TJs may become disrupted, resulting in...

    Authors: David Vermette, Pamela Hu, Michael F Canarie, Melissa Funaro, Janis Glover and Richard W Pierce

    Citation: Intensive Care Medicine Experimental 2018 6:37

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  11. Content type: Research

    We studied a novel approach for the evaluation and management of volemia: minimally invasive monitoring of respiratory blood flow variations in the superior vena cava (SVC). We performed an experiment with 10 ...

    Authors: Tomas Kovarnik, Miroslav Navratil, Jan Belohlavek, Mikulas Mlcek, Martin Chval, Zhi Chen, Stepan Jerabek, Otomar Kittnar and Ales Linhart

    Citation: Intensive Care Medicine Experimental 2018 6:36

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  12. Content type: Research

    There is increasing evidence demonstrating the value of partial extracorporeal CO2 removal (ECCO2R) for the treatment of hypercapnia in patients with acute exacerbations of chronic obstructive pulmonary disease a...

    Authors: Alexandra G. May, R. Garrett Jeffries, Brian J. Frankowski, Greg W. Burgreen and William J. Federspiel

    Citation: Intensive Care Medicine Experimental 2018 6:34

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  13. Content type: Research

    Although mechanical ventilation is often lifesaving, it can also cause injury to the lungs. The lung injury is caused by not only high pressure and mechanical forces but also by inflammatory processes that are...

    Authors: Jonas Tydén, N. Larsson, S. Lehtipalo, H. Herwald, M. Hultin, J. Walldén, A. F. Behndig and J. Johansson

    Citation: Intensive Care Medicine Experimental 2018 6:33

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  14. Content type: Research

    Tissue ATP depletion and oxidative stress have been associated with the severe outcomes of septic shock. One of the compensatory mechanisms to alleviate the sepsis-induced mitochondrial dysfunction could be th...

    Authors: Pierre Eyenga, Damien Roussel, Jerome Morel, Benjamin Rey, Caroline Romestaing, Virginie Gueguen-Chaignon, Shey-Shing Sheu and Jean Paul Viale

    Citation: Intensive Care Medicine Experimental 2018 6:31

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  15. Content type: Research

    In sepsis, early outcome prediction would allow investigation of both adaptive mechanisms underlying survival and maladaptive mechanisms resulting in death. The aim of this study was to test whether early chan...

    Authors: Alain Rudiger, Victor Jeger, Mattia Arrigo, Christian A. Schaer, Florian F. Hildenbrand, Margarete Arras, Burkhardt Seifert, Mervyn Singer, Gabriele Schoedon, Donat R. Spahn and Dominique Bettex

    Citation: Intensive Care Medicine Experimental 2018 6:28

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  16. Content type: Correction

    Following publication of the original article [1], the author reported these required corrections to Fig. 5 and Fig. 6:

    Authors: Jerome Aboab, Louis Mayaud, Veronique Sebille, Rodrigo de Oliveira, Merce Jourdain and Djillali Annane

    Citation: Intensive Care Medicine Experimental 2018 6:29

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    The original article was published in Intensive Care Medicine Experimental 2018 6:14

  17. Content type: Research

    CD31 is a key transmembrane neutrophil immunoregulatory receptor. Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a massive cleavage and shedding of the most extracellular domains of CD3...

    Authors: Quoc Thang Hoang, Alexandre Nuzzo, Liliane Louedec, Sandrine Delbosc, Francesco Andreata, Jamila Khallou-Laschet, Maksud Assadi, Philippe Montravers, Dan Longrois, Olivier Corcos, Giuseppina Caligiuri, Antonino Nicoletti, Jean-Baptiste Michel and Alexy Tran-Dinh

    Citation: Intensive Care Medicine Experimental 2018 6:27

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  18. Content type: Review

    Pre-clinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of pre-clinical models of sep...

    Authors: Marcin F. Osuchowski, Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H. Chaudry, Craig M. Coopersmith, Clifford Deutschman, Susanne Drechsler, Philip Efron, Claes Frostell, Gerhard Fritsch, Waldemar Gozdzik, Judith Hellman, Markus Huber-Lang…

    Citation: Intensive Care Medicine Experimental 2018 6:26

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  19. Content type: Research

    Venovenous extracorporeal membrane oxygenation (vv-ECMO) is an effective treatment for severe respiratory failure. The interaction between the cardiorespiratory system and the oxygenator can be explored with m...

    Authors: Christopher John Joyce, Kiran Shekar and David Andrew Cook

    Citation: Intensive Care Medicine Experimental 2018 6:25

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  20. Content type: Research

    Septic shock is the leading cause of death in intensive care units. The pathophysiological complexity of this syndrome contributes to an absence of specific treatment. Several preclinical studies in murine mod...

    Authors: Caroline Laroye, Jérémie Lemarié, Amir Boufenzer, Pierre Labroca, Lisiane Cunat, Corentine Alauzet, Frédérique Groubatch, Clémence Cailac, Lucie Jolly, Danièle Bensoussan, Loïc Reppel and Sébastien Gibot

    Citation: Intensive Care Medicine Experimental 2018 6:24

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  21. Content type: Research

    Cardiac arrest carries a poor prognosis. The typical cardiac arrest patient is comorbid, and studies have shown that diabetes mellitus is an independent risk factor for increased mortality after cardiac arrest...

    Authors: Lauge Vammen, Søren Rahbek, Niels Secher, Jonas Agerlund Povlsen, Niels Jessen, Bo Løfgren and Asger Granfeldt

    Citation: Intensive Care Medicine Experimental 2018 6:23

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  22. Content type: Research

    Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of lactic acidosis under circumstances where plasma concentrations...

    Authors: Sarah Piel, Johannes K. Ehinger, Imen Chamkha, Eleonor Åsander Frostner, Fredrik Sjövall, Eskil Elmér and Magnus J. Hansson

    Citation: Intensive Care Medicine Experimental 2018 6:22

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  23. Content type: Research

    Methods to guide fluid therapy in spontaneously breathing patients are scarce. No studies have reported the accuracy of end-tidal CO2 (ET-CO2) to predict volume responsiveness in these patients. We sought to eval...

    Authors: María C. Arango-Granados, Virginia Zarama Córdoba, Andrés M. Castro Llanos and Luis A. Bustamante Cristancho

    Citation: Intensive Care Medicine Experimental 2018 6:21

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  24. Content type: Research

    Different mechanical ventilation settings are known to affect lung preservation for lung transplantation. Measurement of particle flow in exhaled air may allow online assessment of the impact of ventilation be...

    Authors: Ellen Broberg, Martiné Wlosinska, Lars Algotsson, Anna-Carin Olin, Darcy Wagner, Leif Pierre and Sandra Lindstedt

    Citation: Intensive Care Medicine Experimental 2018 6:18

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  25. Content type: Research

    Despite increasing ethical standards for conducting animal research, death is still often used as an endpoint in mouse sepsis studies. Recently, the Murine Sepsis Score (MSS), Mouse Clinical Assessment Score f...

    Authors: Safiah H. C. Mai, Neha Sharma, Andrew C. Kwong, Dhruva J. Dwivedi, Momina Khan, Peter M. Grin, Alison E. Fox-Robichaud and Patricia C. Liaw

    Citation: Intensive Care Medicine Experimental 2018 6:20

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  26. Content type: Letter to the Editor

    This study examines the impact of cefepime and APP-β (antipseudomonal penicillin/ β-lactamase inhibitor combinations) on Gram-negative bacterial colonization and resistance in two Australian ICUs. While resist...

    Authors: Carola Venturini, Andrew N. Ginn, Brooke E. Wilson, Guy Tsafnat, Ian Paulsen, Sally R. Partridge and Jonathan R. Iredell

    Citation: Intensive Care Medicine Experimental 2018 6:19

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  27. Content type: Methodology

    Nebulised antibiotics are frequently used for the prevention or treatment of ventilator-associated pneumonia. Many factors may influence pulmonary drug concentrations with inaccurate dosing schedules potential...

    Authors: Jayesh A. Dhanani, Jeremy Cohen, Suzanne L. Parker, Hak-Kim Chan, Patricia Tang, Benjamin J. Ahern, Adeel Khan, Manoj Bhatt, Steven Goodman, Sara Diab, Jivesh Chaudhary, Jeffrey Lipman, Steven C. Wallis, Adrian Barnett, Michelle Chew, John F. Fraser…

    Citation: Intensive Care Medicine Experimental 2018 6:17

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  28. Content type: Research

    The acute respiratory distress syndrome (ARDS) is one of the main causes of mortality in adults admitted to intensive care units. Previous studies have demonstrated the existence of genetic variants involved i...

    Authors: Natalia Hernandez-Pacheco, Beatriz Guillen-Guio, Marialbert Acosta-Herrera, Maria Pino-Yanes, Almudena Corrales, Alfonso Ambrós, Leonor Nogales, Arturo Muriel, Elena González-Higueras, Francisco J. Diaz-Dominguez, Elizabeth Zavala, Javier Belda, Shwu-Fan Ma, Jesús Villar and Carlos Flores

    Citation: Intensive Care Medicine Experimental 2018 6:16

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  29. Content type: Research

    Influenza infections are often complicated by secondary infections, which are associated with high morbidity and mortality, suggesting that influenza profoundly influences the immune response towards a subsequ...

    Authors: R. M. Koch, D. A. Diavatopoulos, G. Ferwerda, P. Pickkers, M. I. de Jonge and M. Kox

    Citation: Intensive Care Medicine Experimental 2018 6:15

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  30. Content type: Research

    There is an increasing interest in beta-blockade as a therapeutic approach to sepsis following consistent experimental findings of attenuation of inflammation and improved survival with beta1 selective antagon...

    Authors: Jerome Aboab, Louis Mayaud, Veronique Sebille, Rodrigo de Oliveira, Merce Jourdain and Djillali Annane

    Citation: Intensive Care Medicine Experimental 2018 6:14

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    The Correction to this article has been published in Intensive Care Medicine Experimental 2018 6:29

  31. Content type: Research

    A dysregulated stress response has been implicated in the pathogenesis of critical illness. Sedative agents utilised in the critically unwell patient may impact upon the stress response with a downstream negat...

    Authors: John P. R. Moore, Chris Anstey, Lauren Murray, John F. Fraser and Mervyn Singer

    Citation: Intensive Care Medicine Experimental 2018 6:13

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  32. Content type: Research

    Bias flow (BF) is essential to maintain mean airway pressure (MAP) and to washout carbon dioxide (CO2) from the oscillator circuit during high-frequency oscillatory ventilation (HFOV). If the BF rate is inadequat...

    Authors: Osamu Nagano, Tetsuya Yumoto, Atsunori Nishimatsu, Shunsuke Kanazawa, Takahisa Fujita, Sunao Asaba and Hideo Yamanouchi

    Citation: Intensive Care Medicine Experimental 2018 6:11

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  33. Content type: Review

    Chloride is the principal anion of the extracellular fluid and vital for both serum electroneutrality and acid-base homeostasis. The aim of this review is to investigate the relevance of dyschloremia in the cr...

    Authors: Carmen Andrea Pfortmueller, Dominik Uehlinger, Stephan von Haehling and Joerg Christian Schefold

    Citation: Intensive Care Medicine Experimental 2018 6:10

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  34. Content type: Research

    Body positioning affects the configuration and dynamic properties of the chest wall and therefore may influence decisions made to increase or decrease ventilating pressures and tidal volume. We hypothesized th...

    Authors: Gustavo A. Cortes-Puentes, Kenneth E. Gard, Alexander B. Adams, David J. Dries, Michael Quintel, Richard A. Oeckler, Luciano Gattinoni and John J. Marini

    Citation: Intensive Care Medicine Experimental 2018 6:9

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  35. Content type: Research

    Catheter suctioning of respiratory secretions in intubated subjects is limited to the proximal airway and associated with traumatic lesions to the mucosa and poor tolerance. “Mechanical insufflation-exsufflati...

    Authors: Miguel Sánchez-García, Passio Santos, Gema Rodríguez-Trigo, Fernando Martínez-Sagasti, Tomás Fariña-González, Ángela del Pino-Ramírez, Carlos Cardenal-Sánchez, Beatriz Busto-González, Mónica Requesens-Solera, Mercedes Nieto-Cabrera, Francisco Romero-Romero and Antonio Núñez-Reiz

    Citation: Intensive Care Medicine Experimental 2018 6:8

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  36. Content type: Research

    Although clinical studies of the high-flow nasal cannula (HFNC) and its effect on positive end-expiratory pressure (PEEP) have been done, the washout effect has not been well evaluated. Therefore, we made an e...

    Authors: Yu Onodera, Ryo Akimoto, Hiroto Suzuki, Masayuki Okada, Masaki Nakane and Kaneyuki Kawamae

    Citation: Intensive Care Medicine Experimental 2018 6:7

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  37. Content type: Research

    Extracorporeal membrane oxygenation (ECMO) delivers cardiac and/or respiratory support to critically ill patients who have failed conventional medical therapies. If the large-bore cannulas used to deliver ECMO...

    Authors: Taressa Bull, Amanda Corley, Danielle J. Smyth, David J. McMillan, Kimble R. Dunster and John F. Fraser

    Citation: Intensive Care Medicine Experimental 2018 6:6

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  38. Content type: Research

    Sepsis-associated hyperlactatemia is a widely used biomarker, associated with initial severity and poor outcomes. This increased circulating lactate concentration has been proposed to result in part from a mis...

    Authors: Thibaut Girardot, Thomas Rimmelé, Guillaume Monneret, Julien Textoris and Fabienne Venet

    Citation: Intensive Care Medicine Experimental 2018 6:5

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  39. Content type: Research

    Carbon monoxide (CO) poisoning is the leading cause of poisoning mortality and morbidity in the USA. Carboxyhemoglobin (COHb) levels are not predictive of severity or prognosis. At this time, the measurement o...

    Authors: David H. Jang, Utsha G. Khatri, Brenna P. Shortal, Matthew Kelly, Kevin Hardy, David S. Lambert and David M. Eckmann

    Citation: Intensive Care Medicine Experimental 2018 6:4

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  40. Content type: Research

    Prone position and PEEP can both improve oxygenation and other parameters, but their interaction has not been fully described. Limited data directly compare selection of mechanically “optimal” or “best” PEEP i...

    Authors: Joseph C. Keenan, Gustavo A. Cortes-Puentes, Lei Zhang, Alex B. Adams, David J. Dries and John J. Marini

    Citation: Intensive Care Medicine Experimental 2018 6:3

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  41. Content type: Research

    Automated systems are available in various application areas all over the world for the purpose of reducing workload and increasing safety. However, such support systems that would aid caregivers are still lac...

    Authors: Wilfried Klingert, Jörg Peter, Christian Thiel, Karolin Thiel, Wolfgang Rosenstiel, Kathrin Klingert, Christian Grasshoff, Alfred Königsrainer and Martin Schenk

    Citation: Intensive Care Medicine Experimental 2018 6:2

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  42. Content type: Letter to the Editor

    Monocyte HLA-DR expression has been reported as a marker of immunosuppression and a predictor of sepsis development. However, to date, there is no report on monocyte HLA-DR monitoring exclusively in neonates (...

    Authors: Alexis Chenouard, Cécile Braudeau, Nicolas Cottron, Pierre Bourgoin, Nina Salabert, Antoine Roquilly, Régis Josien, Nicolas Joram and Karim Asehnoune

    Citation: Intensive Care Medicine Experimental 2018 6:1

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  43. Content type: Research

    Fluid resuscitation remains a cornerstone in the management of acute bleeding. According to Starling's “Three-compartment model”, four-times more crystalloids have the same volume effect as colloids. However, ...

    Authors: Ildikó László, Gábor Demeter, Nándor Öveges, Dániel Érces, József Kaszaki, Krisztián Tánczos and Zsolt Molnár

    Citation: Intensive Care Medicine Experimental 2017 5:52

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  44. Content type: Research

    Spinal cord injury (SCI) is a complex disease that leads to a motor, sensitive, and vegetative impairment. So far, single therapies are ineffective for treating SCI in humans and a multifactorial therapeutic a...

    Authors: Mathieu Boutonnet, Elisabeth Laemmel, Eric Vicaut, Jacques Duranteau and Marc Soubeyrand

    Citation: Intensive Care Medicine Experimental 2017 5:51

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