Skip to main content

Articles

Page 1 of 36

  1. This narrative review delves into the intricate interplay between the lungs and the kidneys, with a focus on elucidating the pathogenesis of diseases influenced by immunological factors, acid–base regulation, ...

    Authors: Renata de Souza Mendes, Pedro Leme Silva, Chiara Robba, Denise Battaglini, Miquéias Lopes-Pacheco, Celso Caruso-Neves and Patricia R. M. Rocco
    Citation: Intensive Care Medicine Experimental 2024 12:81
  2. In patients requiring extracorporeal cardiopulmonary resuscitation (ECPR), there is a need for studies to assess the potential benefits of therapeutic interventions to improve survival and reduce hypoxic-ische...

    Authors: Anthony Moreau, Fuhong Su, Filippo Annoni and Fabio Silvio Taccone
    Citation: Intensive Care Medicine Experimental 2024 12:80
  3. Authors: Rosanna D’Albo, Tommaso Pozzi, Rosmery V. Nicolardi, Mauro Galizia, Giulia Catozzi, Valentina Ghidoni, Beatrice Donati, Federica Romitti, Peter Herrmann, Mattia Busana, Simone Gattarello, Francesca Collino, Aurelio Sonzogni, Luigi Camporota, John J. Marini, Onnen Moerer…
    Citation: Intensive Care Medicine Experimental 2024 12:79

    The original article was published in Intensive Care Medicine Experimental 2024 12:65

  4. Endothelial disorders with edema formation and microcirculatory perfusion disturbances are common in cardiac surgery with cardiopulmonary bypass (CPB) and contribute to disturbed tissue oxygenation resulting i...

    Authors: Anne M. Beukers, Anoek L. I. van Leeuwen, Roselique Ibelings, Anita M. Tuip-de Boer, Carolien S. E. Bulte, Susanne Eberl and Charissa E. van den Brom
    Citation: Intensive Care Medicine Experimental 2024 12:78
  5. Alveolar macrophages activation to the pro-inflammatory phenotype M1 is pivotal in the pathophysiology of Ventilator-Induced Lung Injury (VILI). Increased lung strain is a known determinant of VILI, but a dire...

    Authors: Francesco Liggieri, Elena Chiodaroli, Mariangela Pellegrini, Emmi Puuvuori, Jonathan Sigfridsson, Irina Velikyan, Davide Chiumello, Lorenzo Ball, Paolo Pelosi, Sebastiano Stramaglia, Gunnar Antoni, Olof Eriksson and Gaetano Perchiazzi
    Citation: Intensive Care Medicine Experimental 2024 12:77
  6. Circulatory shock and multi-organ failure remain major contributors to morbidity and mortality in critically ill patients and are associated with insufficient oxygen availability in the tissue. Intrinsic mecha...

    Authors: Massimiliano Bertacchi, Pedro D. Wendel-Garcia, Anisa Hana, Can Ince, Marco Maggiorini and Matthias P. Hilty
    Citation: Intensive Care Medicine Experimental 2024 12:76
  7. Sepsis can lead to coagulopathy and microvascular thrombosis. Prior studies, including ours, reported an increased level of extracellular vimentin in blood derived from septic patients. Moreover, we identified...

    Authors: Marina Martinez-Vargas, Arun Saini, Subhashree Pradhan, Luis Gardea, Barbara Stoll, Inka C. Didelija, K. Vinod Vijayan, Trung C. Nguyen and Miguel A. Cruz
    Citation: Intensive Care Medicine Experimental 2024 12:75
  8. Acute respiratory distress syndrome (ARDS) remains a significant challenge in critical care, with high mortality rates despite advancements in treatment. Venovenous extracorporeal membrane oxygenation (VV-ECMO...

    Authors: Maud Vincendeau, Thomas Klein, Frederique Groubatch, N’Guyen Tran, Antoine Kimmoun and Bruno Levy
    Citation: Intensive Care Medicine Experimental 2024 12:74
  9. Circulatory shock, defined as decreased tissue perfusion, leading to inadequate oxygen delivery to meet cellular metabolic demands, remains a common condition with high morbidity and mortality. Rapid restituti...

    Authors: Anne-Aylin Sigg, Vanja Zivkovic, Jan Bartussek, Reto A. Schuepbach, Can Ince and Matthias P. Hilty
    Citation: Intensive Care Medicine Experimental 2024 12:72
  10. Artificial intelligence, through improved data management and automated summarisation, has the potential to enhance intensive care unit (ICU) care. Large language models (LLMs) can interrogate and summarise la...

    Authors: Emma Urquhart, John Ryan, Sean Hartigan, Ciprian Nita, Ciara Hanley, Peter Moran, John Bates, Rachel Jooste, Conor Judge, John G. Laffey, Michael G. Madden and Bairbre A. McNicholas
    Citation: Intensive Care Medicine Experimental 2024 12:71
  11. The European Resuscitation Council 2021 guidelines for haemodynamic monitoring and management during post-resuscitation care from cardiac arrest call for an individualised approach to therapeutic interventions...

    Authors: Anders Aneman, Markus Benedikt Skrifvars and Koen Ameloot
    Citation: Intensive Care Medicine Experimental 2024 12:70
  12. Critical care management heavily relies on accurate cardiac output (CO) measurement. Echocardiography has been a mainstay in non-invasive cardiac monitoring; however, its comparability to invasive methods warr...

    Authors: María Camila Arango-Granados, Jaime Andrés Quintero-Ramírez, Felipe Mejía-Herrera, Lina Mayerly Henao-Cardona, Valentina Muñoz-Patiño and Luis Alfonso Bustamante-Cristancho
    Citation: Intensive Care Medicine Experimental 2024 12:69
  13. Infusion of exogenous catecholamines (i.e., norepinephrine [NE] and dobutamine) is a recommended treatment for septic shock with myocardial dysfunction. However, sustained catecholamine infusion is linked to c...

    Authors: William Salvail, Dany Salvail, Frédéric Chagnon and Olivier Lesur
    Citation: Intensive Care Medicine Experimental 2024 12:68
  14. Individualised bedside adjustment of mechanical ventilation is a standard strategy in acute coma neurocritical care patients. This involves customising positive end-expiratory pressure (PEEP), which could impr...

    Authors: Vera Spatenkova, Mikulas Mlcek, Alan Mejstrik, Lukas Cisar and Eduard Kuriscak
    Citation: Intensive Care Medicine Experimental 2024 12:67
  15. IL-6 is a pleiotropic cytokine modulating inflammation and metabolic pathways. Its proinflammatory effect plays a significant role in organ failure pathogenesis, commonly elevated in systemic inflammatory cond...

    Authors: Susanne Himmelein, Aritz Perez Ruiz de Garibay, Veronika Brandel, Frank Zierfuß and Tobias Michael Bingold
    Citation: Intensive Care Medicine Experimental 2024 12:66
  16. Mechanical power (MP) is a summary variable incorporating all causes of ventilator-induced-lung-injury (VILI). We expressed MP as the ratio between observed and normal expected values (MPratio).

    Authors: Rosanna D’Albo, Tommaso Pozzi, Rosmery V. Nicolardi, Mauro Galizia, Giulia Catozzi, Valentina Ghidoni, Beatrice Donati, Federica Romitti, Peter Herrmann, Mattia Busana, Simone Gattarello, Francesca Collino, Aurelio Sonzogni, Luigi Camporota, John J. Marini, Onnen Moerer…
    Citation: Intensive Care Medicine Experimental 2024 12:65

    The Correction to this article has been published in Intensive Care Medicine Experimental 2024 12:79

  17. People with type 2 diabetes mellitus treated with sodium-glucose transporter-2 inhibitors (SGLT2i) have lower rates of acute kidney injury (AKI). Sepsis is responsible for the majority of AKI in critically ill...

    Authors: Abraham H. Hulst, Connie P. C. Ow, Clive N. May, Sally H. Hood, Mark P. Plummer, Jeroen Hermanides, Daniël H. van Raalte, Adam M. Deane, Rinaldo Bellomo and Yugeesh R. Lankadeva
    Citation: Intensive Care Medicine Experimental 2024 12:64
  18. Tracheostomized patients often present with muscle weakness, altered consciousness, or swallowing difficulties. Hence, the literature is scarce regarding the challenging management of tracheostomy weaning. The...

    Authors: Yann Combret, Margaux Machefert, Guillaume Prieur, Emeline Fresnel, Elise Artaud-Macari, Bouchra Lamia, Marius Lebret and Clément Medrinal
    Citation: Intensive Care Medicine Experimental 2024 12:63
  19. For decades, left ventricular ejection fraction (LVEF < 35%) has been a mainstay for identifying heart failure (HF) patients most likely to benefit from an implantable cardioverter defibrillator (ICD). However...

    Authors: Nathan Engstrom, Hayley L. Letson, Kevin Ng and Geoffrey P. Dobson
    Citation: Intensive Care Medicine Experimental 2024 12:62
  20. Currently, there is no marker of efficacy of red blood cell (RBC) transfusion. This study describes the impact of RBC transfusion on mitochondrial oxygen tension (mitoPO2) and mitochondrial oxygen consumption (mi...

    Authors: M. Baysan, B. Hilderink, L. van Manen, C. Caram-Deelder, E. G. Mik, N. P. Juffermans, J. G. van der Bom and M. S. Arbous
    Citation: Intensive Care Medicine Experimental 2024 12:61
  21. The spatiotemporal progression and patterns of tissue deformation in ventilator-induced lung injury (VILI) remain understudied. Our aim was to identify lung clusters based on their regional mechanical behavior...

    Authors: Pablo Cruces, Jaime Retamal, Andrés Damián, Graciela Lago, Fernanda Blasina, Vanessa Oviedo, Tania Medina, Agustín Pérez, Lucía Vaamonde, Rosina Dapueto, Sebastian González-Dambrauskas, Alberto Serra, Nicolas Monteverde-Fernandez, Mauro Namías, Javier Martínez and Daniel E. Hurtado
    Citation: Intensive Care Medicine Experimental 2024 12:60
  22. Treatment and prevention of intracranial hypertension (IH) to minimize secondary brain injury are central to the neurocritical care management of traumatic brain injury (TBI). Predicting the onset of IH in adv...

    Authors: Jun Zhu, Yingchi Shan, Yihua Li, Xuxu Xu, Xiang Wu, Yajun Xue and Guoyi Gao
    Citation: Intensive Care Medicine Experimental 2024 12:58
  23. A sepsis-like syndrome is known to occur after cardiac arrest, leading to cerebral infiltration by white blood cells (WBC). We hypothesized that pharmacological sequestration of WBC, and more specifically lymp...

    Authors: Yara Abi Zeid Daou, Fanny Lidouren, Antoine Bois, Naoto Watanabe, Ali Jendoubi, Estelle Faucher, Mathieu Surenaud, Sophie Chateau-Joubert, Sophie Hue, Bijan Ghaleh, Matthias Kohlhauer and Renaud Tissier
    Citation: Intensive Care Medicine Experimental 2024 12:57
  24. The aim of this experimental study was to elucidate whether different distances between central venous catheter tips can affect drug clearance during continuous renal replacement therapy (CRRT). Central venous...

    Authors: Anna Bandert, Miklós Lipcsey, Robert Frithiof, Anders Larsson and David Smekal
    Citation: Intensive Care Medicine Experimental 2024 12:56
  25. Risk stratification and outcome prediction are crucial for intensive care resource planning. In addressing the large data sets of intensive care unit (ICU) patients, we employed the Explainable Boosting Machin...

    Authors: Andreas Körner, Benjamin Sailer, Sibel Sari-Yavuz, Helene A. Haeberle, Valbona Mirakaj, Alice Bernard, Peter Rosenberger and Michael Koeppen
    Citation: Intensive Care Medicine Experimental 2024 12:55
  26. Continuous monitoring of mitral annular plane systolic excursion (MAPSE) using transesophageal echocardiography (TEE) may improve the evaluation of left ventricular (LV) function in postoperative intensive car...

    Authors: Jinyang Yu, Anders Austlid Taskén, Erik Andreas Rye Berg, Tomas Dybos Tannvik, Katrine Hordnes Slagsvold, Idar Kirkeby-Garstad, Bjørnar Grenne, Gabriel Kiss and Svend Aakhus
    Citation: Intensive Care Medicine Experimental 2024 12:54
  27. Dipeptidyl peptidase 3 (DPP3) is a ubiquitous cytosolic enzyme released into the bloodstream after tissue injury, that can degrade angiotensin II. High concentrations of circulating DPP3 (cDPP3) have been asso...

    Authors: Bruno Garcia, Benoit ter Schiphorst, Karine Santos, Fuhong Su, Laurence Dewachter, Francisco Vasques-Nóvoa, Estela Rocha-Oliveira, Roberto Roncon-Albuquerque Jr., Theo Uba, Oliver Hartmann, Adrien Picod, Feriel Azibani, Jacques Callebert, Serge Goldman, Filippo Annoni, Raphaël Favory…
    Citation: Intensive Care Medicine Experimental 2024 12:53
  28. Recirculation is a common problem in venovenous extracorporeal membrane oxygenation (VV ECMO) and may limit the effect of ECMO treatment due to less efficient blood oxygenation or unfavorable ECMO and ventilat...

    Authors: Lars Prag Antonsen, Andreas Espinoza, Per Steinar Halvorsen, Itai Schalit, Harald Bergan, Didrik Lilja and Svein Aslak Landsverk
    Citation: Intensive Care Medicine Experimental 2024 12:51
  29. Pancreatic stone protein (PSP) exhibits potential as a plasma biomarker for infection diagnosis and risk stratification in critically ill patients, but its significance in nosocomial infection and intensive ca...

    Authors: Diede Verlaan, Lennie P. G. Derde, Tom van der Poll, Marc J. M. Bonten and Olaf L. Cremer
    Citation: Intensive Care Medicine Experimental 2024 12:50
  30. We tested the ability of a physiologically driven minimally invasive closed-loop algorithm, called Resuscitation based on Functional Hemodynamic Monitoring (ReFit), to stabilize for up to 3 h a porcine model o...

    Authors: Michael R. Pinsky, Hernando Gomez, Francis X. Guyette, Leonard Weiss, Artur Dubrawski, Jim Leonard, Robert MacLachlan, Lisa Gordon, Theodore Lagattuta, David Salcido and Ronald Poropatich
    Citation: Intensive Care Medicine Experimental 2024 12:44
  31. Catecholamines are commonly used as therapeutic drugs in intensive care medicine to maintain sufficient organ perfusion during shock. However, excessive or sustained adrenergic activation drives detrimental ca...

    Authors: Christine Bode, Sebastian Preissl, Lutz Hein and Achim Lother
    Citation: Intensive Care Medicine Experimental 2024 12:48
  32. Therapeutic drug monitoring (TDM) of anti-infectives such as linezolid is routinely performed in blood of intensive care unit (ICU) patients to optimize target attainment. However, the concentration at the sit...

    Authors: Diana Rebholz, Uwe Liebchen, Michael Paal, Michael Vogeser, Johannes Starp, Caroline Gräfe, Clara I. Brozat, Felix L. Happich, Katharina Habler and Christina Scharf
    Citation: Intensive Care Medicine Experimental 2024 12:47
  33. Assessment of dynamic parameters to guide fluid administration is one of the mainstays of current resuscitation strategies. Each test has its own limitations, but passive leg raising (PLR) has emerged as one o...

    Authors: Mario Bruna, Sebastian Alfaro, Felipe Muñoz, Liliana Cisternas, Cecilia Gonzalez, Rodrigo Conlledo, Rodrigo Ulloa-Morrison, Marcos Huilcaman, Jaime Retamal, Ricardo Castro, Philippe Rola, Adrian Wong, Eduardo R. Argaiz, Roberto Contreras, Glenn Hernandez and Eduardo Kattan
    Citation: Intensive Care Medicine Experimental 2024 12:46
  34. Lung volume optimization maneuvers (LVOM) are necessary to make physiologic use of high-frequency oscillatory ventilation (HFOV), but lung behavior during such maneuvers has not been studied to determine lung ...

    Authors: Pauline de Jager, Alette A. Koopman, Dick G. Markhorst and Martin C. J. Kneyber
    Citation: Intensive Care Medicine Experimental 2024 12:42
  35. The continuous exposure of blood to a non-biological surface during extracorporeal membrane oxygenation (ECMO) may lead to progressive thrombus formation in the oxygenator, hemolysis and consequently impaired ...

    Authors: Rolf Erlebach, Alix Buhlmann, Rea Andermatt, Benjamin Seeliger, Klaus Stahl, Christian Bode, Reto Schuepbach, Pedro David Wendel-Garcia and Sascha David
    Citation: Intensive Care Medicine Experimental 2024 12:41
  36. To assess the incidences of Herpes Simplex-1 and 2 (HSV-1, HSV-2), Cytomegalovirus (CMV), Epstein–Barr Virus (EBV) reactivations in critically ill COVID-19 patients. To determine the association between viral ...

    Authors: Alessia Mattei, Lorenzo Schiavoni, Elisabetta Riva, Massimo Ciccozzi, Roberta Veralli, Angela Urselli, Vincenzo Citriniti, Antonio Nenna, Giuseppe Pascarella, Fabio Costa, Rita Cataldo, Felice Eugenio Agrò and Massimiliano Carassiti
    Citation: Intensive Care Medicine Experimental 2024 12:40
  37. In selected cases of cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is combined with trans valvular micro axial flow pumps (ECMELLA). Observational studies indicate that ECMELL...

    Authors: Emilie Gregers, Peter H. Frederiksen, Nanna L. J. Udesen, Louise Linde, Ann Banke, Amalie L. Povlsen, Jeppe P. Larsen, Christian Hassager, Lisette O. Jensen, Jens F. Lassen, Henrik Schmidt, Hanne B. Ravn, Peter M. H. Heegaard and Jacob E. Møller
    Citation: Intensive Care Medicine Experimental 2024 12:39
  38. The use of hemoadsorption (HA) has become popular in the treatment of vasoplegic states associated with massive cytokine release, including septic shock. However, this approach does not seem to be based on rob...

    Authors: Vaclav Tegl, Jan Horak, Lukas Nalos, Michala Horakova, Milan Stengl, Martin Matejovic and Jan Benes
    Citation: Intensive Care Medicine Experimental 2024 12:38
  39. Administration of oxygen therapy is common, yet there is a lack of knowledge on its ability to prevent cellular hypoxia as well as on its potential toxicity. Consequently, the optimal oxygenation targets in cl...

    Authors: Bashar N. Hilderink, Reinier F. Crane, Bas van den Bogaard, Janesh Pillay and Nicole P. Juffermans
    Citation: Intensive Care Medicine Experimental 2024 12:37
  40. In refractory out-of-hospital cardiac arrest, the patient is commonly transported to hospital with mechanical continuous chest compressions (CCC). Limited data are available on the optimal ventilation strategy...

    Authors: Jukka Kopra, Erik Litonius, Pirkka T. Pekkarinen, Merja Laitinen, Juho A. Heinonen, Luca Fontanelli and Markus B. Skrifvars
    Citation: Intensive Care Medicine Experimental 2024 12:36
  41. The same principle behind pulse wave analysis can be applied on the pulmonary artery (PA) pressure waveform to estimate right ventricle stroke volume (RVSV). However, the PA pressure waveform might be influenc...

    Authors: Arnoldo Santos, M. Ignacio Monge-García, João Batista Borges, Jaime Retamal, Gerardo Tusman, Anders Larsson and Fernando Suarez-Sipmann
    Citation: Intensive Care Medicine Experimental 2024 12:34
  42. Liver function of intensive care patients is routinely monitored by static blood pathology. For specific indications, liver specific cytochrome activity may be measured by the commercially available maximum li...

    Authors: Thomas Köhler, Elke Schwier, Janina Praxenthaler, Carmen Kirchner, Günther Winde, Björn Koos and Dietrich Henzler
    Citation: Intensive Care Medicine Experimental 2024 12:33
  43. Reinforcement learning (RL) holds great promise for intensive care medicine given the abundant availability of data and frequent sequential decision-making. But despite the emergence of promising algorithms, R...

    Authors: Luca F. Roggeveen, Ali el Hassouni, Harm-Jan de Grooth, Armand R. J. Girbes, Mark Hoogendoorn and Paul W. G. Elbers
    Citation: Intensive Care Medicine Experimental 2024 12:32